Tissue-engineered pumps and valves and uses thereof

Title: Tissue-engineered pumps and valves and uses thereof

The present invention provides tissue-engineered pumps and valves, methods of fabricating such pumps and valves, and methods of use of such pumps and valves.

Inventors:: Parker, Kevin Kit; Goss, Josue A.; Park, Sung-Jin; Capulli, Andrew K.; Golecki, Holly M.; Nawroth, Janna C.; Dabiri, John O.

Issue Date:: 2017-06-06

OSTI Identifier:: 1361631

Assignee:: President and Fellows of Harvard College LANL

Patent Number(s):: 9,669,141

Application Number:: 14/415,945

Contract Number:: AC52-06NA25396

Resource Relation:: Patent File Date: 2013 Jul 19

Research Org:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING

Full Text
View Full Text

Have feedback or suggestions for a way to improve these results? !

Save / Share this Record no
Export Metadata
- Endnote
- RIS
- Excel
- CSV
- XML
Send to Email

Send to Email

Email address:

Content:

Works referenced in this record:

Engineered cell growth on polymeric films and biotechnological applications thereof
patent, July 2013

Parker, Kevin Kit; Feinberg, Adam W.; Whitesides, George M.
US Patent Document 8,492,150
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F8492150

Devices comprising muscle thin films and uses thereof in high throughput assays for determining contractile function
patent, April 2015

Parker, Kevin Kit; Feinberg, Adam Walter; Alford, Patrick W.
US Patent Document 9,012,172
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F9012172

Boundary conditions for the arrangement of cells and tissues
patent, June 2015

Feinberg, Adam W.; Parker, Kevin Kit; Kuo, Po-Ling
US Patent Document 9,068,168
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F9068168

Heart muscle-like cell sheet, three-dimensional construct, heart muscle-like tissue and process for producing the same
patent-application, January 2004

Okano, Teruo; Shimizu, Tatsuya; Yamato, Masayuki
US Patent Application \t10/333473; 20040009566
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040009566%22.PGNR.&OS=DN/20040009566&RS=DN/20040009566

Biocompatible scaffolds with tissue fragments
patent-application, April 2004

Binette, Francois; Hwang, Julia; Dhanaraj, Sridevi
US Patent Application 10/374772; 20040078090
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040078090%22.PGNR.&OS=DN/20040078090&RS=DN/20040078090

Self-assembled muscle-powered microdevices
patent-application, May 2004

Montemagno, Carlo D.; Neves, Hercules P.
US Patent Application \t10/635933; 20040101819
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040101819%22.PGNR.&OS=DN/20040101819&RS=DN/20040101819

Prevention of myocardial infarction induced ventricular expansion and remodeling
patent-application, April 2005

Santamore, William P.; Lesniak, Jeanne M.
US Patent Application \t10/958063; 20050080402
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050080402%22.PGNR.&OS=DN/20050080402&RS=DN/20050080402

Fiber based embolism protection device
patent-application, April 2005

Galdonik, Jason A.; Ogle, Matthew F.; Pokorney, Jim
US Patent Application 10/795131; 20050085847
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050085847%22.PGNR.&OS=DN/20050085847&RS=DN/20050085847

Microfluidic system
patent-application, January 2006

Ismagilov, Rustem F.; Zheng, Bo; Gerdts, Cory J.
US Patent Application \t11/174298; 20060003439
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060003439%22.PGNR.&OS=DN/20060003439&RS=DN/20060003439

Production of tissue engineered heart valves
patent-application, November 2006

Atala, Anthony; Yoo, James J.
US Patent Application \t11/373066; 20060253192
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060253192%22.PGNR.&OS=DN/20060253192&RS=DN/20060253192

Electroactive polymer devices for moving fluid
patent-application, July 2007

Pelrine, Ronald E.; Kornbluh, Roy David; Heydt, Richard
US Patent Application \t11/645226; 20070164641
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070164641%22.PGNR.&OS=DN/20070164641&RS=DN/20070164641

Method for making a blood pump and pumping blood
patent-application, August 2007

Palmer, Arthur
US Patent Application 11/788668; 20070197857
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070197857%22.PGNR.&OS=DN/20070197857&RS=DN/20070197857

Use of Modulators of a Novel Form of Muscle Selective Calcineurin Interacting Protein (Mcip-1-38) as a Treatment for Cardiovascular Diseases
patent-application, February 2008

Bush, Erik; Hood, David
US Patent Application \t11/575462; 20080031818
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080031818%22.PGNR.&OS=DN/20080031818&RS=DN/20080031818

Engineered Cell Growth on Polymeric Films and Biotechnological Applications Thereof
patent-application, December 2009

Parker, Kevin Kit; Feinberg, Adam W.; Whitesides, George M.
US Patent Application \t12/223560; 20090317852
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220090317852%22.PGNR.&OS=DN/20090317852&RS=DN/20090317852

BIOPOLYMER STRUCTURES
patent-application, August 2010

Feinberg, Adam W.; Parker, Kevin Kit
US Patent Application \t12/443890; 20100196432
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220100196432%22.PGNR.&OS=DN/20100196432&RS=DN/20100196432

BOUNDARY CONDITIONS FOR THE ARRANGEMENT OF CELLS AND TISSUES
patent-application, December 2010

Feinberg, Adam W.; Parker, Kevin Kit; Kuo, Po-Ling
US Patent Application \t12/680277; 20100330644
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220100330644%22.PGNR.&OS=DN/20100330644&RS=DN/20100330644

MICROFLUIDIC PUMP AND VALVE STRUCTURES AND FABRICATION METHODS
patent-application, February 2011

Zhou, Peng; Young, Lincoln C.
US Patent Application 12/855058; 20110041935
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220110041935%22.PGNR.&OS=DN/20110041935&RS=DN/20110041935

METHODS OF GENERATING PATTERNED SOFT SUBSTRATES AND USES THEREOF
patent-application, August 2011

Kuo, Po-Ling; Feinberg, Adam W.; Parker, Kevin Kit
US Patent Application 12/994187; 20110189719
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220110189719%22.PGNR.&OS=DN/20110189719&RS=DN/20110189719

METHODS AND DEVICES FOR THE FABRICATION OF 3D POLYMERIC FIBERS
patent-application, May 2012

Parker, Kevin Kit; Badrossamay, Mohammad Reza; Goss, Josue Adrian
US Patent Application 13/320031; 20120135448
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220120135448%22.PGNR.&OS=DN/20120135448&RS=DN/20120135448

HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN
patent-application, June 2012

Parker, Kevin Kit; Feinberg, Adam Walter; Alford, Patrick W.
US Patent Application \t13/318227; 20120142556
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220120142556%22.PGNR.&OS=DN/20120142556&RS=DN/20120142556

METHODS OF GENERATING ENGINEERED INNERVATED TISSUE AND USES THEREOF
patent-application, February 2013

Parker, Kevin Kit; Feinberg, Adam W.; Chin, Lauren E.M.
US Patent Application\t13/580191; 20130046134
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220130046134%22.PGNR.&OS=DN/20130046134&RS=DN/20130046134

HYDRAULIC HYDRAULIC PULSATION EQUIPMENT FOR A PERFUSION PUMP
patent-application, February 2013

Merce Vives, Salvador
US Patent Application 13/592439; 20130053625
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220130053625%22.PGNR.&OS=DN/20130053625&RS=DN/20130053625

SYSTEMS, DEVICES AND METHODS FOR THE FABRICATION OF POLYMERIC FIBERS
patent-application, November 2013

Parker, Kevin Kit; Badrossamay, Mohammad Reza; Goss, Josue Adrian
US Patent Application 13/988088; 20130312638
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220130312638%22.PGNR.&OS=DN/20130312638&RS=DN/20130312638

ANISOTROPIC BIOLOGICAL PACEMAKERS AND AV BYPASSES
patent-application, December 2013

Parker, Kevin Kit; Ripplinger, Crystal M.; Feinberg, Adam W.
US Patent Application 13/878383; 20130330378
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220130330378%22.PGNR.&OS=DN/20130330378&RS=DN/20130330378

SYSTEMS, DEVICES AND METHODS FOR FABRICATION OF POLYMERIC FIBERS
patent-application, October 2014

Parker, Kevin Kit; Badrossamay, Mohammad Reza; Goss, Josue Adrian
US Patent Application \t14/359005; 20140322515
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220140322515%22.PGNR.&OS=DN/20140322515&RS=DN/20140322515

MUSCLE CHIPS AND METHODS OF USE THEREOF
patent-application, November 2014

Parker, Kevin Kit; Goss, Josue Adrian; Grosberg, Anna
US Patent Application \t14/362287; 20140342394
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220140342394%22.PGNR.&OS=DN/20140342394&RS=DN/20140342394

POLYMERIC FIBER-SCAFFOLDED ENGINEERED TISSUES AND USES THEREOF
patent-application, September 2015

Parker, Kevin Kit; Badrossamay, Mohammad Reza; Agarwal, Ashutosh
US Patent Application \t14/429826; 20150253307
URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220150253307%22.PGNR.&OS=DN/20150253307&RS=DN/20150253307

Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering
journal, August 2007

Parker, K. K.; Ingber, D. E.
Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 362, Issue 1484, p. 1267-1279
DOI: 10.1098/rstb.2007.2114

Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion
journal, January 2004

Lehnert, Dirk; Wehrle-Haller, Bernhard; David, Christian
Journal of Cell Science, Vol. 117, Issue 1, p. 41-52
DOI: 10.1242/jcs.00836

Real-Time Measurement of the Contractile Forces of Self-Organized Cardiomyocytes on Hybrid Biopolymer Microcantilevers
journal, October 2005

Park, Jungyul; Ryu, Jaewook; Choi, Seung Kyu
Analytical Chemistry, Vol. 77, Issue 20, p. 6571-6580
DOI: 10.1021/ac0507800

Similar Records

Similar records in DOepatents and OSTI.GOV collections:

Apparatus comprising magnetically actuated valves and uses thereof

Patent Edwards, Thayne L. ; Harper, Jason C.

The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and anymore »« less
Full Text Available July 2016
Engineered enzymatically active bacteriophages and methods of uses thereof

Patent Collins, James J ; Kobayashi, Hideki ; Kearn, Mads ; Araki, Michihiro ; Friedland, Ari ; Lu, Timothy Kuan-Ta

The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.
Full Text Available May 2012
Engineered high expansion glass-ceramics having near linear thermal strain and methods thereof

Patent Dai, Steve Xunhu ; Rodriguez, Mark A. ; Lyon, Nathanael L.

The present invention relates to glass-ceramic compositions, as well as methods for forming such composition. In particular, the compositions include various polymorphs of silica that provide beneficial thermal expansion characteristics (e.g., a near linear thermal strain). Also described are methods of forming such compositions, as well as connectors including hermetic seals containing such compositions.
Full Text Available January 2018
Engineered high expansion glass-ceramics having near linear thermal strain and methods thereof

Patent Dai, Steve Xunhu ; Rodriguez, Mark A. ; Lyon, Nathanael L.

The present invention relates to glass-ceramic compositions, as well as methods for forming such composition. In particular, the compositions include various polymorphs of silica that provide beneficial thermal expansion characteristics (e.g., a near linear thermal strain). Also described are methods of forming such compositions, as well as connectors including hermetic seals containing such compositions.
Full Text Available August 2018
Fast-acting valve and uses thereof

Patent Meyer, James A.

A very fast acting valve capable of producing a very well-defined plug of gas suitable for filling a theta pinch vacuum vessel is given. The valve requires no springs, instead being stopped mainly by a nonlinear force. Thus, the valve is not subject to bouncing; and the ratio of the size of the valve housing to the size of the valve stem is smaller than it would be if springs were needed to stop the valve stem. Furthermore, the valve can be used for thousands of valve firings with no apparent valve damage.
Full Text Available January 1982