skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Positive modulator of bone morphogenic protein-2

Abstract

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1361549
Patent Number(s):
9670258
Application Number:
15/240,977
Assignee:
Brookhaven Science Associates, LLC
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
ACO2-98CH1086
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Aug 18
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Kazuyuki, Takahashi. Positive modulator of bone morphogenic protein-2. United States: N. p., 2017. Web.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, & Kazuyuki, Takahashi. Positive modulator of bone morphogenic protein-2. United States.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Kazuyuki, Takahashi. Tue . "Positive modulator of bone morphogenic protein-2". United States. https://www.osti.gov/servlets/purl/1361549.
@article{osti_1361549,
title = {Positive modulator of bone morphogenic protein-2},
author = {Zamora, Paul O. and Pena, Louis A. and Lin, Xinhua and Kazuyuki, Takahashi},
abstractNote = {Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {6}
}

Patent:

Save / Share:

Works referenced in this record:

FGF homologs
patent, November 1999


Interleukin-12 fusion protein
patent, November 1999


Osteogenic devices
patent-application, December 2003


Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity
journal, December 1991


Semirational design of a potent, artificial agonist of fibroblast growth factor receptors
journal, December 1999

  • Ballinger, Marcus D.; Shyamala, Venkatakrishna; Forrest, Louise D.
  • Nature Biotechnology, Vol. 17, Issue 12, p. 1199-1204
  • https://doi.org/10.1038/70746

Biosynthesis of human fibroblast growth factor-5.
journal, April 1991


Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis
journal, April 2000


Overlapping Expression and Redundant Activation of Mesenchymal Fibroblast Growth Factor (FGF) Receptors by Alternatively Spliced FGF-8 Ligands
journal, February 1997


Powers and Pitfalls in Sequence Analysis: The 70% Hurdle
journal, April 2000


Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription
journal, January 1992


A Functional Fibroblast Growth Factor-1 Immunoglobulin Fusion Protein
journal, June 1998


Tandem Ligation of Multipartite Peptides with Cell-Permeable Activity
journal, January 2003


Multiple peptide synthesis
journal, April 1995


Bone Morphogenetic Protein Receptor Complexes on the Surface of Live Cells: A New Oligomerization Mode for Serine/Threonine Kinase Receptors
journal, March 2000


Identification and characterization of a novel member of the fibroblast growth factor family
journal, May 1998


Structural and functional characterization of full-length heparin-binding growth associated molecule.
journal, January 1992


Stimulatory Effects of Basic Fibroblast Growth Factor and Bone Morphogenetic Protein-2 on Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells
journal, October 1997


Designing Biomaterials to Direct Biological Responses
journal, June 1999


Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
journal, March 1999


FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation
journal, October 1998


Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: High interspecies homology
journal, April 1990


Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2
journal, September 1999


The NH2-terminal region of the active domain of sonic hedgehog is necessary for its signal transduction
journal, March 1999


Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-β Receptor
journal, March 1995


Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
journal, March 1997


BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
journal, July 2000


Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein
journal, February 2003


Multidomain Synthetic Peptide B2A2 Synergistically Enhances BMP-2 In Vitro
journal, November 2004


Augmentation of osseous phenotypes in vivo with a synthetic peptide
journal, January 2007


Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.
journal, May 1993


The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways
journal, November 2001


Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors
journal, September 1995


Peptide Synthesis via Fragment Condensation
book, November 1994


Structure and Expression of the mRNA Encoding a Novel Fibroblast Growth Factor, FGF-18
journal, July 1998


Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice
journal, July 2001


Polymeric system for dual growth factor delivery
journal, November 2001


αvβ3 Integrin Mediates the Cell-adhesive Capacity and Biological Activity of Basic Fibroblast Growth Factor (FGF-2) in Cultured Endothelial Cells
journal, December 1997


Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide
journal, January 2004


Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)-2
journal, January 2006


The challenges of genome sequence annotation or “The devil is in the details”
journal, November 1997


Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo
journal, June 2000


A Novel Isoform of Human Fibroblast Growth Factor 8 Is Induced by Androgens and Associated with Progression of Esophageal Carcinoma
journal, January 2001


Design of Peptides with High Affinities for Heparin and Endothelial Cell Proteoglycans
journal, March 2000


Engineering of an FGF–proteoglycan fusion protein with heparin-independent, mitogenic activity
journal, June 2000


Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2
journal, October 2002


Local Delivery of Basic Fibroblast Growth Factor (bFGF) Using Adsorbed Silyl-heparin, Benzyl-bis(dimethylsilylmethyl)oxycarbamoyl-heparin
journal, September 2002


The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.
journal, August 1988