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Title: Positive modulator of bone morphogenic protein-2

Abstract

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1361549
Patent Number(s):
9670258
Application Number:
15/240,977
Assignee:
Brookhaven Science Associates, LLC
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
DOE Contract Number:  
ACO2-98CH1086
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Aug 18
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Kazuyuki, Takahashi. Positive modulator of bone morphogenic protein-2. United States: N. p., 2017. Web.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, & Kazuyuki, Takahashi. Positive modulator of bone morphogenic protein-2. United States.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Kazuyuki, Takahashi. Tue . "Positive modulator of bone morphogenic protein-2". United States. https://www.osti.gov/servlets/purl/1361549.
@article{osti_1361549,
title = {Positive modulator of bone morphogenic protein-2},
author = {Zamora, Paul O. and Pena, Louis A. and Lin, Xinhua and Kazuyuki, Takahashi},
abstractNote = {Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {6}
}

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