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Title: Positive modulator of bone morphogenic protein-2

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1361549
Assignee:
Brookhaven Science Associates, LLC LBNL
Patent Number(s):
9,670,258
Application Number:
15/240,977
Contract Number:
ACO2-98CH1086
Resource Relation:
Patent File Date: 2016 Aug 18
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

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