Ultrasensitive biochemical sensing device and method of sensing analytes
Abstract
Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that -s and -p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the -S and -P polarizations give in a signal indicative of presence of the ligand.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1361542
- Patent Number(s):
- 9671327
- Application Number:
- 13/422,718
- Assignee:
- The Regents of the University of Colorado, A Body Corporate
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
- DOE Contract Number:
- AC02-06CH11357
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Mar 16
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Pinchuk, Anatoliy. Ultrasensitive biochemical sensing device and method of sensing analytes. United States: N. p., 2017.
Web.
Pinchuk, Anatoliy. Ultrasensitive biochemical sensing device and method of sensing analytes. United States.
Pinchuk, Anatoliy. Tue .
"Ultrasensitive biochemical sensing device and method of sensing analytes". United States. https://www.osti.gov/servlets/purl/1361542.
@article{osti_1361542,
title = {Ultrasensitive biochemical sensing device and method of sensing analytes},
author = {Pinchuk, Anatoliy},
abstractNote = {Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that -s and -p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the -S and -P polarizations give in a signal indicative of presence of the ligand.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 06 00:00:00 EDT 2017},
month = {Tue Jun 06 00:00:00 EDT 2017}
}
Works referenced in this record:
Polarization based interferometric detector
patent, June 2007
- Hall, John R.; Petropavlovskikh, Viatcheslav; Nilsen, Oyvind
- US Patent Document 7,233,396
Target substance-detecting apparatus and target substance-detecting method
patent, November 2012
- Handa, Yoichiro; Yamada, Tomohiro
- US Patent Document 8,314,935
Nanoparticle optical properties: Far- and near-field electrodynamic coupling in a chain of silver spherical nanoparticles
journal, April 2008
- Pinchuk, Anatoliy O.; Schatz, George C.
- Materials Science and Engineering: B, Vol. 149, Issue 3
A Localized Surface Plasmon Resonance Biosensor: First Steps toward an Assay for Alzheimer's Disease
journal, June 2004
- Haes, Amanda J.; Hall, W. Paige; Chang, Lei
- Nano Letters, Vol. 4, Issue 6, p. 1029-1034
Multiple Label-Free Detection of Antigen−Antibody Reaction Using Localized Surface Plasmon Resonance-Based Core−Shell Structured Nanoparticle Layer Nanochip
journal, September 2006
- Endo, Tatsuro; Kerman, Kagan; Nagatani, Naoki
- Analytical Chemistry, Vol. 78, Issue 18, p. 6465-6475