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Title: Ultrasensitive biochemical sensing device and method of sensing analytes

Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that -s and -p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the -S and -P polarizations give in a signal indicative of presence of the ligand.
Inventors:
Issue Date:
OSTI Identifier:
1361542
Assignee:
The Regents of the University of Colorado, A Body Corporate ANL
Patent Number(s):
9,671,327
Application Number:
13/422,718
Contract Number:
AC02-06CH11357
Resource Relation:
Patent File Date: 2012 Mar 16
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

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