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Title: Imaging agents for monitoring changes of dopamine receptors and methods of using thereof

The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.
Inventors:
; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1360974
Assignee:
The Regents of the University of California CHO
Patent Number(s):
9,662,059
Application Number:
12/110,135
Contract Number:
FG02-03ER63598
Resource Relation:
Patent File Date: 2008 Apr 25
Research Org:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Other works cited in this record:

Brain imaging of 18F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors
journal, September 2002
  • Mukherjee, Jogeshwar; Christian, Bradley T.; Dunigan, Kelly A.
  • Synapse, Vol. 46, Issue 3, p. 170-188
  • DOI: 10.1002/syn.10128

Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion
journal, August 2005
  • RubĂ­, Blanca; Ljubicic, Sanda; Pournourmohammadi, Shirin
  • Journal of Biological Chemistry, Vol. 280, Issue 44, p. 36824-36832
  • DOI: 10.1074/jbc.M505560200

Imaging inflammation of the pancreatic islets in type 1 diabetes
journal, August 2004
  • Denis, M. C.; Mahmood, U.; Benoist, C.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 34, p. 12634-12639
  • DOI: 10.1073/pnas.0404307101

Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro
journal, March 2006
  • Shankar, Eswar; Santhosh, K.; Paulose, C.
  • IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), Vol. 58, Issue 3, p. 157-163
  • DOI: 10.1080/15216540600687993

18F-Fallypride PET of Pancreatic Islets: In Vitro and In Vivo Rodent Studies
journal, June 2011
  • Garcia, A.; Mirbolooki, M. R.; Constantinescu, C.
  • Journal of Nuclear Medicine, Vol. 52, Issue 7, p. 1125-1132
  • DOI: 10.2967/jnumed.111.088583

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