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Title: Imaging agents for monitoring changes of dopamine receptors and methods of using thereof

Abstract

The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1360974
Patent Number(s):
9662059
Application Number:
12/110,135
Assignee:
The Regents of the University of California
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
FG02-03ER63598
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Apr 25
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Mukherjee, Jogeshwar, Chandy, George, Milne, Norah, Wang, Ping H., Easwaramoorthy, Balu, Mantil, Joseph, and Garcia, Adriana. Imaging agents for monitoring changes of dopamine receptors and methods of using thereof. United States: N. p., 2017. Web.
Mukherjee, Jogeshwar, Chandy, George, Milne, Norah, Wang, Ping H., Easwaramoorthy, Balu, Mantil, Joseph, & Garcia, Adriana. Imaging agents for monitoring changes of dopamine receptors and methods of using thereof. United States.
Mukherjee, Jogeshwar, Chandy, George, Milne, Norah, Wang, Ping H., Easwaramoorthy, Balu, Mantil, Joseph, and Garcia, Adriana. Tue . "Imaging agents for monitoring changes of dopamine receptors and methods of using thereof". United States. https://www.osti.gov/servlets/purl/1360974.
@article{osti_1360974,
title = {Imaging agents for monitoring changes of dopamine receptors and methods of using thereof},
author = {Mukherjee, Jogeshwar and Chandy, George and Milne, Norah and Wang, Ping H. and Easwaramoorthy, Balu and Mantil, Joseph and Garcia, Adriana},
abstractNote = {The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {5}
}

Works referenced in this record:

Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion
journal, August 2005


Imaging inflammation of the pancreatic islets in type 1 diabetes
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Diagnosis and Localization of Focal Congenital Hyperinsulinism by 18F-Fluorodopa PET Scan
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Fluorine-18-l-Dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography as a Tool to Localize an Insulinoma or β-Cell Hyperplasia in Adult Patients
journal, April 2007


11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain
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Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro
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Current Progress in Non-Invasive Imaging of Beta Cell Mass of the Endocrine Pancreas
journal, October 2006


Longitudinal noninvasive PET-based   cell mass estimates in a spontaneous diabetes rat model
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Systematic screening of potential β-cell imaging agents
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18F-Fallypride PET of Pancreatic Islets: In Vitro and In Vivo Rodent Studies
journal, June 2011