Imaging agents for monitoring changes of dopamine receptors and methods of using thereof

Title: Imaging agents for monitoring changes of dopamine receptors and methods of using thereof

The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.

Inventors:: Mukherjee, Jogeshwar; Chandy, George; Milne, Norah; Wang, Ping H.; Easwaramoorthy, Balu; Mantil, Joseph; Garcia, Adriana

Issue Date:: 2017-05-30

OSTI Identifier:: 1360974

Assignee:: The Regents of the University of California CHO

Patent Number(s):: 9,662,059

Application Number:: 12/110,135

Contract Number:: FG02-03ER63598

Resource Relation:: Patent File Date: 2008 Apr 25

Research Org:: The Regents of the University of California, Oakland, CA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

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Other works cited in this record:

Brain imaging of ¹⁸F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors
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Mukherjee, Jogeshwar; Christian, Bradley T.; Dunigan, Kelly A.
Synapse, Vol. 46, Issue 3, p. 170-188
DOI: 10.1002/syn.10128

Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion
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Rubí, Blanca; Ljubicic, Sanda; Pournourmohammadi, Shirin
Journal of Biological Chemistry, Vol. 280, Issue 44, p. 36824-36832
DOI: 10.1074/jbc.M505560200

Imaging inflammation of the pancreatic islets in type 1 diabetes
journal, August 2004

Denis, M. C.; Mahmood, U.; Benoist, C.
Proceedings of the National Academy of Sciences, Vol. 101, Issue 34, p. 12634-12639
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Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro
journal, March 2006

Shankar, Eswar; Santhosh, K.; Paulose, C.
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), Vol. 58, Issue 3, p. 157-163
DOI: 10.1080/15216540600687993

¹⁸F-Fallypride PET of Pancreatic Islets: In Vitro and In Vivo Rodent Studies
journal, June 2011

Garcia, A.; Mirbolooki, M. R.; Constantinescu, C.
Journal of Nuclear Medicine, Vol. 52, Issue 7, p. 1125-1132
DOI: 10.2967/jnumed.111.088583

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