Title: Disposable world-to-chip interface for digital microfluidics

Abstract

The present disclosure sets forth incorporating microfluidic chips interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact, integrated platforms that interface with a chip upstream and downstream of the reaction, as well as between intermediate reaction steps if needed. In some embodiments these interfaces are automated, including automation of a multiple reagent process. Various reagent delivery systems and methods are also disclosed.

Inventors:

Van Dam, R. Michael; Shah, Gaurav; Keng, Pei-Yuin

Issue Date:

2017-05-16

Research Org.:

Univ. of California, Oakland, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1357556

Patent Number(s):

9649632

Application Number:

14/406,195

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2200/027 - for microfluidic devices
B01L2200/0673 - Handling of plugs of fluid surrounded by immiscible fluid
B01L2300/0681 - Filter
B01L2400/0487 - fluid pressure, pneumatics
B01L2400/0622 - distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2035/00158 - {Elements containing microarrays, i.e. "biochip"}
G01N2035/1034 - {Transferring microquantities of liquid}
G01N35/10 - Devices for transferring samples {or any liquids} to, in, or from, the analysis apparatus, e.g. suction devices, injection devices {

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DOE Contract Number:  

SC0001249; SC0005056

Resource Type:

Patent

Resource Relation:

Patent File Date: 2013 Jun 10

Country of Publication:

United States

Language:

English

Subject:

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY