Apolipoprotein nanodiscs with telodendrimer
Abstract
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1356293
- Patent Number(s):
- 9644038
- Application Number:
- 13/719,785
- Assignee:
- The Regents of the University of California
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Dec 19
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Apolipoprotein nanodiscs with telodendrimer. United States: N. p., 2017.
Web.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, & Xing, Li. Apolipoprotein nanodiscs with telodendrimer. United States.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Tue .
"Apolipoprotein nanodiscs with telodendrimer". United States. https://www.osti.gov/servlets/purl/1356293.
@article{osti_1356293,
title = {Apolipoprotein nanodiscs with telodendrimer},
author = {Luo, Juntao and He, Wei and Lam, Kit S. and Henderson, Paul and Coleman, Matthew and Cheng, R. Holland and Xing, Li},
abstractNote = {The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {5}
}
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