Apolipoprotein nanodiscs with telodendrimer

Luo, Juntao; He, Wei; Lam, Kit S.; Henderson, Paul; Coleman, Matthew; Cheng, R. Holland; Xing, Li

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
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B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
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B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
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C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
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C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
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D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
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E01 - construction of roads, railways, or bridges
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F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
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F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
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H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
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Y04 - information or communication technologies having an impact on other technology areas
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Title: Apolipoprotein nanodiscs with telodendrimer

Abstract

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Inventors:: Luo, Juntao; He, Wei; Lam, Kit S.; Henderson, Paul; Coleman, Matthew; Cheng, R. Holland; Xing, Li

Issue Date:: 2017-05-09

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1356293

Patent Number(s):: 9644038

Application Number:: 13/719,785

Assignee:: The Regents of the University of California

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/775 - Apolipopeptides
C07K17/02 - Peptides being immobilised on, or in, an organic carrier

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DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Dec 19

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Apolipoprotein nanodiscs with telodendrimer.  United States: N. p., 2017. 
        Web.

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                    Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, & Xing, Li. Apolipoprotein nanodiscs with telodendrimer.  United States.

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                    Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Tue .  
        "Apolipoprotein nanodiscs with telodendrimer".  United States.  https://www.osti.gov/servlets/purl/1356293.

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@article{osti_1356293,

  title        = {Apolipoprotein nanodiscs with telodendrimer},

  author       = {Luo, Juntao and He, Wei and Lam, Kit S. and Henderson, Paul and Coleman, Matthew and Cheng, R. Holland and Xing, Li},

  abstractNote = {The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2017},

  month        = {5}

}

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Similar Records

Title: Apolipoprotein nanodiscs with telodendrimer

Abstract

Citation Formats

Method for forming proteoliposome and method for forming giant proteoliposome patent, December 1994

Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof patent, April 2002

Membrane scaffold proteins patent, August 2006

Lipophilic drug delivery vehicle and methods of use thereof patent, November 2010

Novel targeted delivery systems for bioactive agents patent-application, April 2002

Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof patent-application, January 2006

Amplification of biotin-mediated targeting patent-application, June 2006

In Vitro Protein Synthesis Systems For Membrane Proteins That Include Adolipoproteins And Phospholipid-Adolipoprotein Particles patent-application, May 2007

Drug-Polymer Conjugates Coupled to a Peptidic Carrier patent-application, August 2008

Isolated Phospholipid-Protein Particles patent-application, October 2008

Methods and Systems for Monitoring Production of a Target Protein In a Nanolipoprotein Particle patent-application, May 2009

Nanolipoprotein Particles Comprising Hydrogenases and Related Products, Methods and Systems patent-application, July 2009

Nanolipoprotein Particles And Related Methods And Systems For Protein Capture, Solubilization, And/Or Purification patent-application, July 2009

Lysine-Based Polymeric Linkers patent-application, August 2009

Nanolipoprotein Particles and Related Compositions, Methods and Systems patent-application, December 2009

Immunostimulatory Nanoparticles and Related Compositions, Methods and Systems patent-application, April 2010

Nanoparticles for Delivery of Therapeutic Agents Using Ultrasound and Associated Methods patent-application, June 2010

Nanocarriers for Drug Delivery patent-application, November 2011

Telodendrimer Nanodiscs Without Apolipoprotein patent-application, June 2013

Fluorescence Study of Inclusion Complexes between Star-Shaped Cholic Acid Derivatives and Polycyclic Aromatic Fluorescent Probes and the Size Effects of Host and Guest Molecules journal, March 2008

The dawning era of polymer therapeutics journal, May 2003

Asymmetric Poly(ethylene glycol) Star Polymers with a Cholic Acid Core and Their Aggregation Properties journal, April 2009

A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer journal, October 2009

PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma journal, October 2011

A Simple Construction of a Bile Acid Based Dendritic Light Harvesting System journal, June 2005

Method for forming proteoliposome and method for forming giant proteoliposome
patent, December 1994

Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof
patent, April 2002

Membrane scaffold proteins
patent, August 2006

Lipophilic drug delivery vehicle and methods of use thereof
patent, November 2010

Novel targeted delivery systems for bioactive agents
patent-application, April 2002

Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof
patent-application, January 2006

Amplification of biotin-mediated targeting
patent-application, June 2006

In Vitro Protein Synthesis Systems For Membrane Proteins That Include Adolipoproteins And Phospholipid-Adolipoprotein Particles
patent-application, May 2007

Drug-Polymer Conjugates Coupled to a Peptidic Carrier
patent-application, August 2008

Isolated Phospholipid-Protein Particles
patent-application, October 2008

Methods and Systems for Monitoring Production of a Target Protein In a Nanolipoprotein Particle
patent-application, May 2009

Nanolipoprotein Particles Comprising Hydrogenases and Related Products, Methods and Systems
patent-application, July 2009

Nanolipoprotein Particles And Related Methods And Systems For Protein Capture, Solubilization, And/Or Purification
patent-application, July 2009

Lysine-Based Polymeric Linkers
patent-application, August 2009

Nanolipoprotein Particles and Related Compositions, Methods and Systems
patent-application, December 2009

Immunostimulatory Nanoparticles and Related Compositions, Methods and Systems
patent-application, April 2010

Nanoparticles for Delivery of Therapeutic Agents Using Ultrasound and Associated Methods
patent-application, June 2010

Nanocarriers for Drug Delivery
patent-application, November 2011

Telodendrimer Nanodiscs Without Apolipoprotein
patent-application, June 2013

Fluorescence Study of Inclusion Complexes between Star-Shaped Cholic Acid Derivatives and Polycyclic Aromatic Fluorescent Probes and the Size Effects of Host and Guest Molecules
journal, March 2008

The dawning era of polymer therapeutics
journal, May 2003

Asymmetric Poly(ethylene glycol) Star Polymers with a Cholic Acid Core and Their Aggregation Properties
journal, April 2009

A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer
journal, October 2009

PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma
journal, October 2011

A Simple Construction of a Bile Acid Based Dendritic Light Harvesting System
journal, June 2005