Formation of stable submicron peptide or protein particles by thin film freezing

Johnston, Keith P.; Engstrom, Joshua; Williams, Robert O.

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Title: Formation of stable submicron peptide or protein particles by thin film freezing

Abstract

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.

Inventors:: Johnston, Keith P.; Engstrom, Joshua; Williams, III, Robert O.

Issue Date:: 2017-04-18

Research Org.:: Board of Regents, The University of Texas System, Austin, TX (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1351888

Patent Number(s):: 9622974

Application Number:: 14/603,211

Assignee:: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K9/1658 - {Proteins, e.g. albumin, gelatin}
A61K9/1682 - {Processes}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P15/10 - for impotence
A61P25/16 - Anti-Parkinson drugs
A61P25/34 - Tobacco-abuse
A61P3/10 - for hyperglycaemia, e.g. antidiabetics
A61P35/00 - Antineoplastic agents
A61P7/02 - Antithrombotic agents
A61P9/12 - Antihypertensives

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D9/005 - {Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T428/2982 - Particulate matter [e.g., sphere, flake, etc.]

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DOE Contract Number:: FG02-04ER15549

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Jan 22

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE

Citation Formats


                    Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing.  United States: N. p., 2017. 
        Web.

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                    Johnston, Keith P., Engstrom, Joshua, & Williams, III, Robert O. Formation of stable submicron peptide or protein particles by thin film freezing.  United States.

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                    Johnston, Keith P., Engstrom, Joshua, and Williams, III, Robert O. Tue .  
        "Formation of stable submicron peptide or protein particles by thin film freezing".  United States.  https://www.osti.gov/servlets/purl/1351888.

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@article{osti_1351888,

  title        = {Formation of stable submicron peptide or protein particles by thin film freezing},

  author       = {Johnston, Keith P. and Engstrom, Joshua and Williams, III, Robert O.},

  abstractNote = {The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2017},

  month        = {4}

}

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Patent:

Works referenced in this record:

Injectable Oily Peptide Preparations and Processes for Their Manufacture
patent, March 1975

Geller, Leo
US Patent Document 3,869,549
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/3869549

Cosmetic and pharmaceutical vehicle thickened with solid emulsifier
patent, January 1982

Chang, Tiang-Shing; Zientek, Lucy J.
US Patent Document 4,310,516
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4310516

Pseudoplastic gel transfer
patent, May 1986

Lauchenauer, Alfred E.
US Patent Document 4,588,614
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4588614

Highly pseudoplastic polymer solutions
patent, June 1986

Greminger, Jr., George K.; Dehnke, Mary K.
US Patent Document 4,594,108
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4594108

Droplet freezing method and apparatus
patent, July 1989

Davis, Robert B.; DeVack, Donald Leonard
US Patent Document 4,848,094
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4848094

Ophthalmological composition of the type which undergoes liquid-gel phase transition
patent, August 1989

Mazuel, Claude; Friteyre, Marie-Claire
US Patent Document 4,861,760
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4861760

Sustained release, comfort formulation for glaucoma therapy
patent, March 1990

Jani, Rajni; Harris, Robert G.
US Patent Document 4,911,920
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4911920

Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
patent, May 1993

Missel, Paul J. T.; Lang, John C.; Jani, Rajni
US Patent Document 5,212,162
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5212162

Pharmaceutical composition in gel form in a dispensing package
patent, April 1994

Tachon, Pierre; Vagneur, Beatrice; Viret, Jean-Louis
US Patent Document 5,300,302
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5300302

Injectable extended release formulations and methods
patent, October 1994

Brooks, Norman D.; Needham, Gregory F.
US Patent Document 5,352,662
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5352662

Use of carrageenans in topical ophthalmic compositions
patent, April 1995

Lang, John C.; Keister, Jamieson C.; Missel, Paul J. T.
US Patent Document 5,403,841
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5403841

Prolonged release of biologically active somatotropin
patent, May 1995

Mitchell, James W.
US Patent Document 5,411,951
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5411951

Oral sustained release drug delivery device
patent, April 1996

Landrau, Felix A.; Campbell, Patricia S.; Hall, Arthur W.
US Patent Document 5,512,293
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5512293

Viscous suspensions of controlled-release drug particles
patent, July 1996

Roorda, Wouter E.; Ehnow, Fred
US Patent Document 5,540,912
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5540912

Erosion rate modifier for use in bioerodible drug delivery devices and method of use
patent, November 1996

Roorda, Wouter E.; Ehnow, Fred
US Patent Document 5,571,525
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5571525

Method for identifying an oligonucleotide aptamer specific for a target
patent, December 1996

Toole, John J.; Latham, John; Bock, Louis C.
US Patent Document 5,582,981
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5582981

Methods of producing nucleic acid ligands
patent, January 1997

Gold, Larry; Tuerk, Craig
US Patent Document 5,595,877
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5595877

Method of preparing a drug delivery system comprising a drug and a gel using a syringe
patent, March 1997

Fjellstrom, Torsten
US Patent Document 5,614,221
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5614221

Pharmaceutical formulation
patent, June 1997

Nystrom, Christer; Paalzow, Lennart; Aquilonius, Sten-Magnus
US Patent Document 5,635,213
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5635213

Systematic evolution of ligands by exponential enrichment: chimeric selex
patent, June 1997

Burke, Donald; Tarasow, Ted; Eaton, Bruce
US Patent Document 5,637,459
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5637459

Protein formulation
patent, July 2001

Andya, James; Cleland, Jeffrey L.; Hsu, Chung C.
US Patent Document 6,267,958
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6267958

Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
patent, August 2007

Berry, Stephen A.; Fereira, Pamela J.; Dehnad, Houdin
US Patent Document 7,258,869
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7258869

Production of microspheres
patent, May 2008

Brown, Larry R.
US Patent Document 7,374,782
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7374782

Nanoclusters for delivery of therapeutics
patent, January 2010

Berkland, Cory; Shi, Lianjun
US Patent Document 7,651,770
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7651770

Spherical protein particles and methods for making and using them
patent, August 2011

Yakovlevsky, Kirill; Shamashkin, Michael; Khalaf, Nazer
US Patent Document 7,998,477
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7998477

Low viscosity highly concentrated suspensions
patent, July 2014

Johnston, Keith P.; Mazuski, Maria Andrea; Engstrom, Joshua
US Patent Document 8,779,094
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8779094