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Title: Formation of stable submicron peptide or protein particles by thin film freezing

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1351888
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS CHO
Patent Number(s):
9,622,974
Application Number:
14/603,211
Contract Number:
FG02-04ER15549
Resource Relation:
Patent File Date: 2015 Jan 22
Research Org:
Board of Regents, The University of Texas System, Austin, TX (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE

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