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Title: Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate

One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
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Issue Date:
OSTI Identifier:
Lallemand Hungary Liquidity Management LLC (Budapest, HU) GFO
Patent Number(s):
Application Number:
Contract Number:
FC36-08GO18103; FC36-07GO17057
Resource Relation:
Patent File Date: 2011 May 05
Research Org:
Lallemand Hungary Liquidity Management LLC, Budapest, HU (Hungary)
Sponsoring Org:
Country of Publication:
United States

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