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Title: Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate

Abstract

One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

Inventors:
; ; ; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Lallemand Hungary Liquidity Management LLC, Budapest, HU (Hungary)
Sponsoring Org.:
USDOE
OSTI Identifier:
1348376
Patent Number(s):
9605269
Application Number:
13/696,207
Assignee:
Lallemand Hungary Liquidity Management LLC (Budapest, HU)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12R - PROCESSES USING MICROORGANISMS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FC36-08GO18103; FC36-07GO17057
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 May 05
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Sillers, William Ryan, Van Dijken, Hans, Licht, Steve, Shaw, IV, Arthur J., Gilbert, Alan Benjamin, Argyros, Aaron, Froehlich, Allan C., McBride, John E., Xu, Haowen, Hogsett, David A., and Rajgarhia, Vineet B. Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate. United States: N. p., 2017. Web.
Sillers, William Ryan, Van Dijken, Hans, Licht, Steve, Shaw, IV, Arthur J., Gilbert, Alan Benjamin, Argyros, Aaron, Froehlich, Allan C., McBride, John E., Xu, Haowen, Hogsett, David A., & Rajgarhia, Vineet B. Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate. United States.
Sillers, William Ryan, Van Dijken, Hans, Licht, Steve, Shaw, IV, Arthur J., Gilbert, Alan Benjamin, Argyros, Aaron, Froehlich, Allan C., McBride, John E., Xu, Haowen, Hogsett, David A., and Rajgarhia, Vineet B. Tue . "Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate". United States. https://www.osti.gov/servlets/purl/1348376.
@article{osti_1348376,
title = {Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate},
author = {Sillers, William Ryan and Van Dijken, Hans and Licht, Steve and Shaw, IV, Arthur J. and Gilbert, Alan Benjamin and Argyros, Aaron and Froehlich, Allan C. and McBride, John E. and Xu, Haowen and Hogsett, David A. and Rajgarhia, Vineet B.},
abstractNote = {One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {3}
}

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