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Title: Positron emission tomography probe to monitor selected sugar metabolism in vivo

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1346982
Assignee:
The Regents of the University of California CHO
Patent Number(s):
9,592,309
Application Number:
14/399,701
Contract Number:
SC0001249
Resource Relation:
Patent File Date: 2013 May 09
Research Org:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION

Other works cited in this record:

Synthesis of 2′-Deoxy-2′-Fluoro- 1-Β- D -Arabinofuranosyl Uracil Derivatives: A Method Suitable For Preparation of [18F]-Labeled Nucleosides
journal, August 2002
  • Alauddin, Mian M.; Conti, Peter S.; Fissekis, John D.
  • Synthetic Communications, Vol. 32, Issue 11, p. 1757-1764
  • DOI: 10.1081/SCC-120004272

Autoradiolysis of the 2-deoxy-2-[18F]fluoro-D-glucose radiopharmaceutical
journal, May 2005
  • Búriová, E.; Macášek, F.; Melichar, F.
  • Journal of Radioanalytical and Nuclear Chemistry, Vol. 264, Issue 3, p. 595-602
  • DOI: 10.1007/s10967-005-0759-9

Biodistribution and PET imaging of [18F]-fluoroadenosine derivatives
journal, April 2007

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