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Title: Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1346066
Assignee:
President and Fellows of Harvard College CHO
Patent Number(s):
9,587,252
Application Number:
14/674,895
Contract Number:
FG02-02ER63445
Resource Relation:
Patent File Date: 2015 Mar 31
Research Org:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Visualization of RNA in living cells
patent,  

CRISPR-Cas systems and methods for altering expression of gene products
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journal, July 2013

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journal, February 2013

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journal, June 2012

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journal, February 2012
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  • DOI: 10.1038/nature10886

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