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Title: Sequestration of carbon dioxide with hydrogen to useful products

Abstract

Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
University of Georgia Research Foundation, Inc. Athens, GA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1346064
Patent Number(s):
9587256
Application Number:
14/426,290
Assignee:
University of Georgia Research Foundation, Inc.
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AR0000081
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Sep 06
Country of Publication:
United States
Language:
English
Subject:
08 HYDROGEN; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Adams, Michael W. W., Kelly, Robert M., Hawkins, Aaron B., Menon, Angeli Lal, Lipscomb, Gina Lynette Pries, and Schut, Gerrit Jan. Sequestration of carbon dioxide with hydrogen to useful products. United States: N. p., 2017. Web.
Adams, Michael W. W., Kelly, Robert M., Hawkins, Aaron B., Menon, Angeli Lal, Lipscomb, Gina Lynette Pries, & Schut, Gerrit Jan. Sequestration of carbon dioxide with hydrogen to useful products. United States.
Adams, Michael W. W., Kelly, Robert M., Hawkins, Aaron B., Menon, Angeli Lal, Lipscomb, Gina Lynette Pries, and Schut, Gerrit Jan. Tue . "Sequestration of carbon dioxide with hydrogen to useful products". United States. https://www.osti.gov/servlets/purl/1346064.
@article{osti_1346064,
title = {Sequestration of carbon dioxide with hydrogen to useful products},
author = {Adams, Michael W. W. and Kelly, Robert M. and Hawkins, Aaron B. and Menon, Angeli Lal and Lipscomb, Gina Lynette Pries and Schut, Gerrit Jan},
abstractNote = {Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {3}
}

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