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Title: Expanding the eukaryotic genetic code

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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OSTI Identifier:
The Scripps Reserach Institute OAK
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Resource Relation:
Patent File Date: 2014 Dec 17
Research Org:
The Scripps Reserach Institute, La Jolla, CA (United States)
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Country of Publication:
United States

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