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Title: Radioisotope trithiol complexes

Abstract

The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.

Inventors:
; ;
Issue Date:
Research Org.:
THE CURATORS OF THE UNIVERSITY OF MISSOURI, Columbia, MO (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1344768
Patent Number(s):
9427483
Application Number:
14/679,520
Assignee:
THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, MO)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
SC0003851
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Apr 06
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Jurisson, Silvia S., Cutler, Cathy S., and Degraffenreid, Anthony J. Radioisotope trithiol complexes. United States: N. p., 2016. Web.
Jurisson, Silvia S., Cutler, Cathy S., & Degraffenreid, Anthony J. Radioisotope trithiol complexes. United States.
Jurisson, Silvia S., Cutler, Cathy S., and Degraffenreid, Anthony J. Tue . "Radioisotope trithiol complexes". United States. https://www.osti.gov/servlets/purl/1344768.
@article{osti_1344768,
title = {Radioisotope trithiol complexes},
author = {Jurisson, Silvia S. and Cutler, Cathy S. and Degraffenreid, Anthony J.},
abstractNote = {The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {8}
}

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Works referenced in this record:

Robust gold nanoparticles stabilized by trithiol for application in chemiresistive sensors
journal, September 2010


Amphiphilic Trithiols RC(CH 2 SH) 3
journal, January 2006


A new method for radiochemical separation of arsenic from irradiated germanium oxide
journal, September 2005


Separation of no-carrier-added arsenic-77 from neutron irradiated germanium
journal, January 2009