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Title: Bacterial production of methyl ketones

The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.
Inventors:
;
Issue Date:
OSTI Identifier:
1342098
Assignee:
The Regents of the University of California LBNL
Patent Number(s):
9,556,458
Application Number:
14/354,510
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2012 Oct 26
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Works referenced in this record:

Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals
journal, August 2011
  • Dellomonaco, Clementina; Clomburg, James M.; Miller, Elliot N.
  • Nature, Vol. 476, Issue 7360, p. 355-359
  • DOI: 10.1038/nature10333

Synthesis of methyl ketones by metabolically engineered Escherichia coli
journal, August 2012
  • Park, John; Rodríguez-Moyá, María; Li, Mai
  • Journal of Industrial Microbiology & Biotechnology, Vol. 39, Issue 11, p. 1703-1712
  • DOI: 10.1007/s10295-012-1178-x