Bacterial production of methyl ketones

Title: Bacterial production of methyl ketones

The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.

Inventors:: Beller, Harry R.; Goh, Ee-Been

Issue Date:: 2017-01-31

OSTI Identifier:: 1342098

Assignee:: The Regents of the University of California LBNL

Patent Number(s):: 9,556,458

Application Number:: 14/354,510

Contract Number:: AC02-05CH11231

Resource Relation:: Patent File Date: 2012 Oct 26

Research Org:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

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Works referenced in this record:

Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals
journal, August 2011

Dellomonaco, Clementina; Clomburg, James M.; Miller, Elliot N.
Nature, Vol. 476, Issue 7360, p. 355-359
DOI: 10.1038/nature10333

Synthesis of methyl ketones by metabolically engineered Escherichia coli
journal, August 2012

Park, John; Rodríguez-Moyá, María; Li, Mai
Journal of Industrial Microbiology & Biotechnology, Vol. 39, Issue 11, p. 1703-1712
DOI: 10.1007/s10295-012-1178-x

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