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Title: Micro-fluidic partitioning between polymeric sheets for chemical amplification and processing

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.
Inventors:
Issue Date:
OSTI Identifier:
1340580
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) LLNL
Patent Number(s):
9,550,186
Application Number:
14/695,968
Contract Number:
AC52-07NA27344
Resource Relation:
Patent File Date: 2015 Apr 24
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Other works cited in this record:

Apparatus for cutting and/or welding flexible packaging
patent, March 2001

High speed form, fill and seal pouch packaging machine
patent, July 2004

Chemical amplification based on fluid partitioning
patent, May 2006

Polymer-based platform for microfluidic systems
patent, October 2009

Chemical amplification based on fluid partitioning in an immiscible liquid
patent, September 2010

Microfluidic reaction apparatus for high throughput screening
patent, October 2010

Microfluidic device and methods of using same
patent, November 2010

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