Transgenic cells with increased plastoquinone levels and methods of use
Abstract
Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the disclosed transgenic cells have increased plastoquinone levels. Also disclosed are methods of increasing cell growth rates or production of biomass by cultivating transgenic cells expressing a heterologous nucleic acid encoding a PDH protein, a heterologous nucleic acid encoding an HST protein, a heterologous nucleic acid encoding a DXS protein, or a combination of two or more thereof under conditions sufficient to produce cell growth or biomass.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1337682
- Patent Number(s):
- 9528119
- Application Number:
- 14/307,180
- Assignee:
- LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, NM
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Jun 17
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Sayre, Richard T., Subramanian, Sowmya, and Cahoon, Edgar. Transgenic cells with increased plastoquinone levels and methods of use. United States: N. p., 2016.
Web.
Sayre, Richard T., Subramanian, Sowmya, & Cahoon, Edgar. Transgenic cells with increased plastoquinone levels and methods of use. United States.
Sayre, Richard T., Subramanian, Sowmya, and Cahoon, Edgar. Tue .
"Transgenic cells with increased plastoquinone levels and methods of use". United States. https://www.osti.gov/servlets/purl/1337682.
@article{osti_1337682,
title = {Transgenic cells with increased plastoquinone levels and methods of use},
author = {Sayre, Richard T. and Subramanian, Sowmya and Cahoon, Edgar},
abstractNote = {Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the disclosed transgenic cells have increased plastoquinone levels. Also disclosed are methods of increasing cell growth rates or production of biomass by cultivating transgenic cells expressing a heterologous nucleic acid encoding a PDH protein, a heterologous nucleic acid encoding an HST protein, a heterologous nucleic acid encoding a DXS protein, or a combination of two or more thereof under conditions sufficient to produce cell growth or biomass.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {12}
}
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