Rapid and highly fieldable viral diagnostic
The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active RNA viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a DNA reporter construct that is expressed and amplified in the presence of active viral replication.
- Issue Date:
- OSTI Identifier:
- UT-Battelle, LLC (Oak Ridge, TN) ORNL
- Patent Number(s):
- Application Number:
- Contract Number:
- Resource Relation:
- Patent File Date: 2014 Mar 14
- Research Org:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org:
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Other works cited in this record:Development of Dengue type-2 virus replicons expressing GFP reporter gene in study of viral RNA replication
journal, February 2012
- Leardkamolkarn, Vijittra; Sirigulpanit, Wipawan; Chotiwan, Nunya
- Virus Research, Vol. 163, Issue 2, p. 552-562
Hepatitis C virus replicons: dinosaurs still in business?
journal, January 2009
- Woerz, I.; Lohmann, V.; Bartenschlager, R.
- Journal of Viral Hepatitis, Vol. 16, Issue 1, p. 1-9
Cis-active RNA elements (CREs) and picornavirus RNA replication
journal, February 2009
- Steil, Benjamin P.; Barton, David J.
- Virus Research, Vol. 139, Issue 2, p. 240-252
Temperature-dependent production of pseudoinfectious dengue reporter virus particles by complementation
journal, November 2008
- Ansarah-Sobrinho, Camilo; Nelson, Steevenson; Jost, Christiane A.
- Virology, Vol. 381, Issue 1, p. 67-74
Helper virus-independent trans-replication of hepatitis C virus-derived minigenome
journal, January 2007
- Zhang, Jing; Yamada, Osamu; Yoshida, Hiroshi
- Biochemical and Biophysical Research Communications, Vol. 352, Issue 1, p. 170-176
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