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Title: Rapid and highly fieldable viral diagnostic

The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active RNA viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a DNA reporter construct that is expressed and amplified in the presence of active viral replication.
Inventors:
Issue Date:
OSTI Identifier:
1336928
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORNL
Patent Number(s):
9,523,132
Application Number:
14/212,718
Contract Number:
AC05-00OR22725
Resource Relation:
Patent File Date: 2014 Mar 14
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Development of Dengue type-2 virus replicons expressing GFP reporter gene in study of viral RNA replication
journal, February 2012

Hepatitis C virus replicons: dinosaurs still in business?
journal, January 2009

Cis-active RNA elements (CREs) and picornavirus RNA replication
journal, February 2009

Temperature-dependent production of pseudoinfectious dengue reporter virus particles by complementation
journal, November 2008
  • Ansarah-Sobrinho, Camilo; Nelson, Steevenson; Jost, Christiane A.
  • Virology, Vol. 381, Issue 1, p. 67-74
  • DOI: 10.1016/j.virol.2008.08.021

Helper virus-independent trans-replication of hepatitis C virus-derived minigenome
journal, January 2007
  • Zhang, Jing; Yamada, Osamu; Yoshida, Hiroshi
  • Biochemical and Biophysical Research Communications, Vol. 352, Issue 1, p. 170-176
  • DOI: 10.1016/j.bbrc.2006.10.188

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