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Title: Identification and use of genes encoding amatoxin and phallotoxin

Abstract

The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the present invention also relates to methods for detecting Amanita peptide toxin genes for identifying Amanita peptide-producing mushrooms and for diagnosing suspected cases of mushroom poisoning. Further, the present inventions relate to providing kits for diagnosing and monitoring suspected cases of mushroom poisoning in patients.

Inventors:
; ; ;
Issue Date:
Research Org.:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1335867
Patent Number(s):
9518097
Application Number:
12/268,229
Assignee:
Board of Trustees of Michigan State University (East Lansing
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-91ER20021
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Nov 10
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Hallen, Heather E., Walton, Jonathan D., Luo, Hong, and Scott-Craig, John S. Identification and use of genes encoding amatoxin and phallotoxin. United States: N. p., 2016. Web.
Hallen, Heather E., Walton, Jonathan D., Luo, Hong, & Scott-Craig, John S. Identification and use of genes encoding amatoxin and phallotoxin. United States.
Hallen, Heather E., Walton, Jonathan D., Luo, Hong, and Scott-Craig, John S. Tue . "Identification and use of genes encoding amatoxin and phallotoxin". United States. https://www.osti.gov/servlets/purl/1335867.
@article{osti_1335867,
title = {Identification and use of genes encoding amatoxin and phallotoxin},
author = {Hallen, Heather E. and Walton, Jonathan D. and Luo, Hong and Scott-Craig, John S.},
abstractNote = {The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the present invention also relates to methods for detecting Amanita peptide toxin genes for identifying Amanita peptide-producing mushrooms and for diagnosing suspected cases of mushroom poisoning. Further, the present inventions relate to providing kits for diagnosing and monitoring suspected cases of mushroom poisoning in patients.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {12}
}

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Use of Galerina marginata genes and proteins for peptide production
patent, March 2016


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patent-application, August 2001


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patent-application, April 2004


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patent-application, November 2005


Polymorphic markers and methods of genotyping corn
patent-application, June 2006


Nucleic Acid Sample Purification and Enrichment with a Thermo-Affinity Microfluidic Sub-Circuit
patent-application, March 2008


Annotated Plant Genes
patent-application, April 2009


Use Of Galerina Marginata Genes And Proteins For Peptide Production
patent-application, November 2012