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Title: Miniature acoustic wave lysis system and uses thereof

Abstract

The present invention relates to an acoustic lysis system including a disposable cartridge that can be reversibly coupled to a platform having a small, high-frequency piezoelectric transducer array. In particular, the system releases viable DNA, RNA, and proteins from human or bacterial cells, without chemicals or additional processing, to enable high-speed sample preparation for clinical point-of-care medical diagnostics and use with nano/microfluidic cartridges. Also described herein are methods of making and using the system of the invention.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1334665
Patent Number(s):
9512421
Application Number:
14/318,364
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
H - ELECTRICITY H03 - BASIC ELECTRONIC CIRCUITRY H03H - IMPEDANCE NETWORKS, e.g. RESONANT CIRCUITS
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Jun 27
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Branch, Darren W., Vreeland, Erika Cooley, and Smith, Gennifer Tanabe. Miniature acoustic wave lysis system and uses thereof. United States: N. p., 2016. Web.
Branch, Darren W., Vreeland, Erika Cooley, & Smith, Gennifer Tanabe. Miniature acoustic wave lysis system and uses thereof. United States.
Branch, Darren W., Vreeland, Erika Cooley, and Smith, Gennifer Tanabe. Tue . "Miniature acoustic wave lysis system and uses thereof". United States. https://www.osti.gov/servlets/purl/1334665.
@article{osti_1334665,
title = {Miniature acoustic wave lysis system and uses thereof},
author = {Branch, Darren W. and Vreeland, Erika Cooley and Smith, Gennifer Tanabe},
abstractNote = {The present invention relates to an acoustic lysis system including a disposable cartridge that can be reversibly coupled to a platform having a small, high-frequency piezoelectric transducer array. In particular, the system releases viable DNA, RNA, and proteins from human or bacterial cells, without chemicals or additional processing, to enable high-speed sample preparation for clinical point-of-care medical diagnostics and use with nano/microfluidic cartridges. Also described herein are methods of making and using the system of the invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {12}
}

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