Title: Transcription activator-like effectors

Abstract

Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.

Inventors:

Zhang, Feng; Cong, Le; Kosuri, Sriram; Church, George M.

Issue Date:

2016-11-22

Research Org.:

Harvard Univ., Cambridge, MA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1333298

Patent Number(s):

9499592

Application Number:

13/353,662

Assignee:

President and Fellows of Harvard College (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/195 - from bacteria
C07K14/4705 - {stimulating, promoting or activating activity}
C07K2319/00 - Fusion polypeptide
C07K2319/09 - containing a nuclear localisation signal
C07K2319/60 - containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
C07K2319/80 - containing a DNA binding domain, e.g. Lacl or Tet-repressor

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

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DOE Contract Number:  

FG02-02ER63445

Resource Type:

Patent

Resource Relation:

Patent File Date: 2012 Jan 19

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES