Global to push GA events into
skip to main content

Title: Compounds, compositions, pharmaceutical compositions, and methods of use

Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
; ; ;
Issue Date:
OSTI Identifier:
University of Louisville Research Foundation, Inc. (Louisville, KY) CHO
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2012 Nov 16
Research Org:
University of Louisville Research Foundation, Inc. Louisville, KY (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice
journal, January 2006
  • Bastos, G. N. T.; Santos, A. R. S.; Ferreira, V. M. M.
  • Journal of Ethnopharmacology, Vol. 103, Issue 2, p. 241-245
  • DOI: 10.1016/j.jep.2005.08.008

Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways
journal, July 2008
  • Bastos, G. N. T.; Silveira, A. J. A.; Salgado, C. G.
  • Journal of Ethnopharmacology, Vol. 118, Issue 2, p. 246-251
  • DOI: 10.1016/j.jep.2008.04.005

Immune depression in Rhodnius prolixus by seco-steroids, physalins
journal, March 2008

Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis
journal, June 2011
  • Hseu, You-Cheng; Wu, Chi-Rei; Chang, Hsueh-Wei
  • Journal of Ethnopharmacology, Vol. 135, Issue 3, p. 762-771
  • DOI: 10.1016/j.jep.2011.04.016

Physalis angulata induced G2/M phase arrest in human breast cancer cells
journal, July 2006
  • Hsieh, Wen-Tsong; Huang, Kuan-Yuh; Lin, Hui-Yi
  • Food and Chemical Toxicology, Vol. 44, Issue 7, p. 974-983
  • DOI: 10.1016/j.fct.2005.11.013

New cytotoxic withanolides from Physalis peruviana
journal, September 2009

Oxidative stress involvement in Physalis angulata-induced apoptosis in human oral cancer cells
journal, March 2009
  • Lee, H.-Z.; Liu, W.-Z.; Hsieh, W.-T.
  • Food and Chemical Toxicology, Vol. 47, Issue 3, p. 561-570
  • DOI: 10.1016/j.fct.2008.12.013

Withajardins, withanolides with a new type of skeleton structure of withajardins A, B, C and D absolute configuration of withajardin C
journal, January 1994

Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice
journal, August 2010

Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L.
journal, January 2003
  • Soares, Milena B. P.; Bellintani, Moema C.; Ribeiro, Ivone M.
  • European Journal of Pharmacology, Vol. 459, Issue 1, p. 107-112
  • DOI: 10.1016/S0014-2999(02)02829-7

Antihepatoma activity of Physalis angulata and P. peruviana extracts and their effects on apoptosis in human Hep G2 cells
journal, March 2004
  • Wu, Shu-Jing; Ng, Lean-Teik; Chen, Ching-Hsein
  • Life Sciences, Vol. 74, Issue 16, p. 2061-2073
  • DOI: 10.1016/j.lfs.2003.09.058