Nucleic acids encoding mosaic HIV-1 gag proteins

Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy; Fischer, William M.; Theiler, James; Letvin, Norman; Haynes, Barton F.; Hahn, Beatrice H.; Yusim, Karina; Kuiken, Carla

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Title: Nucleic acids encoding mosaic HIV-1 gag proteins

Abstract

The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.

Inventors:: Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy; Fischer, William M.; Theiler, James; Letvin, Norman; Haynes, Barton F.; Hahn, Beatrice H.; Yusim, Karina; Kuiken, Carla

Issue Date:: Tue Nov 15 00:00:00 EST 2016

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1332283

Patent Number(s):: 9492532

Application Number:: 14/689,957

Assignee:: LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos, MX

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K39/00 - Medicinal preparations containing antigens or antibodies
A61K39/12 - Viral antigens
A61K39/21 - Retroviridae, e.g. equine infectious anemia virus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/18 - for HIV
A61P37/04 - Immunostimulants

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2740/16034 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Show less

DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Apr 17

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Korber, Bette T., Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M., Theiler, James, Letvin, Norman, Haynes, Barton F., Hahn, Beatrice H., Yusim, Karina, and Kuiken, Carla. Nucleic acids encoding mosaic HIV-1 gag proteins.  United States: N. p., 2016. 
        Web.

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                    Korber, Bette T., Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M., Theiler, James, Letvin, Norman, Haynes, Barton F., Hahn, Beatrice H., Yusim, Karina, & Kuiken, Carla. Nucleic acids encoding mosaic HIV-1 gag proteins.  United States.

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                    Korber, Bette T., Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M., Theiler, James, Letvin, Norman, Haynes, Barton F., Hahn, Beatrice H., Yusim, Karina, and Kuiken, Carla. Tue .  
        "Nucleic acids encoding mosaic HIV-1 gag proteins".  United States.  https://www.osti.gov/servlets/purl/1332283.

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@article{osti_1332283,

  title        = {Nucleic acids encoding mosaic HIV-1 gag proteins},

  author       = {Korber, Bette T. and Perkins, Simon and Bhattacharya, Tanmoy and Fischer, William M. and Theiler, James and Letvin, Norman and Haynes, Barton F. and Hahn, Beatrice H. and Yusim, Karina and Kuiken, Carla},

  abstractNote = {The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Nov 15 00:00:00 EST 2016},

  month        = {Tue Nov 15 00:00:00 EST 2016}

}

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Works referenced in this record:

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Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
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Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy
US Patent Document 8,119,140
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Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
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Korber, Bette T.; Fischer, William M.; Liao, Hua-Xin
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Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications
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Similar Records

Title: Nucleic acids encoding mosaic HIV-1 gag proteins

Abstract

Citation Formats

Delivery of exogenous DNA sequences in a mammal patent, December 1996

Induction of a protective immune response in a mammal by injecting a DNA sequence patent, December 1996

Generation of antibodies through lipid mediated DNA delivery patent, December 1997

Ancestral and COT viral sequences, proteins and immunogenic compositions patent, February 2010

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens patent, May 2011

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins patent, February 2012

Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens patent, April 2015

Human immunodeficiency virus type 1 clade M mosaic gag polypeptides patent, April 2015

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens patent, June 2015

Antigen Library Immunization patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications patent-application, March 2003

Method for the development of an HIV vaccine patent-application, June 2003

Polyvalent immunogen patent-application, August 2003

Immunogenic, cross-clade, HIV peptides patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection patent-application, October 2003

Polyvalent immunogen patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions patent-application, June 2005

HIV vaccines based on Env of multiple clades of HIV patent-application, December 2006

Consensus/ancestral immunogens patent-application, August 2007

Polyvalent Vaccine patent-application, December 2009

Polyvalent Vaccine patent-application, June 2011

Polyvalent Vaccine patent-application, May 2012

Delivery of exogenous DNA sequences in a mammal
patent, December 1996

Induction of a protective immune response in a mammal by injecting a DNA sequence
patent, December 1996

Generation of antibodies through lipid mediated DNA delivery
patent, December 1997

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent, February 2010

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
patent, May 2011

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
patent, February 2012

Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
patent, April 2015

Human immunodeficiency virus type 1 clade M mosaic gag polypeptides
patent, April 2015

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
patent, June 2015

Antigen Library Immunization
patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications
patent-application, March 2003

Method for the development of an HIV vaccine
patent-application, June 2003

Polyvalent immunogen
patent-application, August 2003

Immunogenic, cross-clade, HIV peptides
patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection
patent-application, October 2003

Polyvalent immunogen
patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent-application, June 2005

HIV vaccines based on Env of multiple clades of HIV
patent-application, December 2006

Consensus/ancestral immunogens
patent-application, August 2007

Polyvalent Vaccine
patent-application, December 2009

Polyvalent Vaccine
patent-application, June 2011

Polyvalent Vaccine
patent-application, May 2012