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Title: Multiscale spectral nanoscopy

Abstract

A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position.

Inventors:
;
Issue Date:
Research Org.:
Princeton Univ., NJ (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1332117
Patent Number(s):
9494518
Application Number:
14/415,779
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, NJ)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
SC0006838
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Jul 18
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 42 ENGINEERING; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Yang, Haw, and Welsher, Kevin. Multiscale spectral nanoscopy. United States: N. p., 2016. Web.
Yang, Haw, & Welsher, Kevin. Multiscale spectral nanoscopy. United States.
Yang, Haw, and Welsher, Kevin. Tue . "Multiscale spectral nanoscopy". United States. https://www.osti.gov/servlets/purl/1332117.
@article{osti_1332117,
title = {Multiscale spectral nanoscopy},
author = {Yang, Haw and Welsher, Kevin},
abstractNote = {A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {11}
}

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