Title: Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry

Abstract

The production and use of semiconducting nanopost arrays made by nanofabrication is described herein. These nanopost arrays (NAPA) provide improved laser ionization yields and controllable fragmentation with switching or modulation capabilities for mass spectrometric detection and identification of samples deposited on them.

Inventors:

Vertes, Akos; Walker, Bennett N.; Stolee, Jessica A.; Retterer, Scott T.

Issue Date:

2016-11-08

Research Org.:

George Washington Univ., Washington, DC (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1331181

Patent Number(s):

9490113

Application Number:

12/755,769

Assignee:

The George Washington University (Washington, DC)

Patent Classifications (CPCs):

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

H01J49/0031 - {Step by step routines describing the use of the apparatus

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

Y02E10/52 - PV systems with concentrators

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/6851 - {Methods of protein analysis involving laser desorption ionisation mass spectrometry}
G01N33/4833 - {of solid biological material, e.g. tissue samples, cell cultures
G01N33/6848 - {Methods of protein analysis involving mass spectrometry}

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

H01J49/0418 - {for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI], surface enhanced laser desorption/ionisation [SELDI] plates}

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DOE Contract Number:  

FG02-01ER15129

Resource Type:

Patent

Resource Relation:

Patent File Date: 2010 Apr 07

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY