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Title: Modular radiochemistry synthesis system

A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module,more » a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.« less
Inventors:
; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1330694
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA) CHO
Patent Number(s):
9,481,705
Application Number:
14/941,164
Contract Number:
FG02-06ER64249
Resource Relation:
Patent File Date: 2015 Nov 13
Research Org:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Other works cited in this record:

Synthesis of 2′-deoxy-2′-[18F]fluoro-β-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation: synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU
journal, April 2003
  • Mangner, Thomas J.; Klecker, Raymond W.; Anderson, Lawrence
  • Nuclear Medicine and Biology, Vol. 30, Issue 3, p. 215-224
  • DOI: 10.1016/S0969-8051(02)00445-6

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