Title: Digital microfluidic platform for radiochemistry

Abstract

Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing .sup.18F.

Inventors:

Van Dam, Michael R.; Kim, Chang-Jin; Chen, Supin; Ding, Huijiang; Shah, Gaurav Jitendra; Keng, Pei Yuin

Issue Date:

2016-11-01

Research Org.:

Univ. of California, Oakland, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1330683

Patent Number(s):

9481615

Application Number:

14/879,623

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J2219/00853 - Employing electrode arrangements
B01J2219/00783 - Laminate assemblies, i.e. the reactor comprising a stack of plates
B01J2219/00873 - Heat exchange

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C07H1/00 - Processes for the preparation of sugar derivatives

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2400/0427 - Electrowetting
B01L3/502784 - {specially adapted for droplet or plug flow, e.g. digital microfluidics
B01L2400/0487 - fluid pressure, pneumatics

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C07B39/00 - Halogenation

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C201/12 - by reactions not involving the formation of nitro groups

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C07B2200/05 - Isotopically modified compounds, e.g. labelled

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

C07D473/18 - one oxygen and one nitrogen atom, e.g. guanine

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C227/16 - by reactions not involving the amino or carboxyl groups

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C07B59/002 - {Heterocyclic compounds}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2300/1827 - using resistive heater

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY

C07B59/001 - {Acyclic or carbocyclic compounds}
C07B59/005 - {Sugars

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J19/0093 - {Microreactors, e.g. miniaturised or microfabricated reactors

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DOE Contract Number:  

SC0005056

Resource Type:

Patent

Resource Relation:

Patent File Date: 2015 Oct 09

Country of Publication:

United States

Language:

English

Subject:

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 47 OTHER INSTRUMENTATION