Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
Abstract
Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1330676
- Patent Number(s):
- 9480653
- Application Number:
- 14/627,739
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Feb 20
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Brinker, Jeffrey C., Ashley, Carlee Erin, Jiang, Xingmao, Liu, Juewen, Peabody, David S., Wharton, Walker Richard, Carnes, Eric, Chackerian, Bryce, and Willman, Cheryl L. Protocells and their use for targeted delivery of multicomponent cargos to cancer cells. United States: N. p., 2016.
Web.
Brinker, Jeffrey C., Ashley, Carlee Erin, Jiang, Xingmao, Liu, Juewen, Peabody, David S., Wharton, Walker Richard, Carnes, Eric, Chackerian, Bryce, & Willman, Cheryl L. Protocells and their use for targeted delivery of multicomponent cargos to cancer cells. United States.
Brinker, Jeffrey C., Ashley, Carlee Erin, Jiang, Xingmao, Liu, Juewen, Peabody, David S., Wharton, Walker Richard, Carnes, Eric, Chackerian, Bryce, and Willman, Cheryl L. Tue .
"Protocells and their use for targeted delivery of multicomponent cargos to cancer cells". United States. https://www.osti.gov/servlets/purl/1330676.
@article{osti_1330676,
title = {Protocells and their use for targeted delivery of multicomponent cargos to cancer cells},
author = {Brinker, Jeffrey C. and Ashley, Carlee Erin and Jiang, Xingmao and Liu, Juewen and Peabody, David S. and Wharton, Walker Richard and Carnes, Eric and Chackerian, Bryce and Willman, Cheryl L.},
abstractNote = {Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 01 00:00:00 EDT 2016},
month = {Tue Nov 01 00:00:00 EDT 2016}
}
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