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Title: Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
Inventors:
; ; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1330676
Assignee:
Sandia Corporation (Albuquerque, NM) SNL-A
Patent Number(s):
9,480,653
Application Number:
14/627,739
Resource Relation:
Patent File Date: 2015 Feb 20
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
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Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
journal, June 2013

Delivery of Ricin Toxin A-Chain by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers
journal, April 2012
  • Epler, Katharine; Padilla, David; Phillips, Genevieve
  • Advanced Healthcare Materials, Vol. 1, Issue 3, p. 348-353
  • DOI: 10.1002/adhm.201200022

Silica nanoparticle supported lipid bilayers for gene delivery
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Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery
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  • DOI: 10.1021/ja902039y

Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120
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