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Title: Microscopy imaging device with advanced imaging properties

Abstract

Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1330343
Patent Number(s):
9474448
Application Number:
14/884,543
Assignee:
The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G06 - COMPUTING G06T - IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Oct 15
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Ghosh, Kunal, Burns, Laurie, El Gamal, Abbas, Schnitzer, Mark J., Cocker, Eric, and Ho, Tatt Wei. Microscopy imaging device with advanced imaging properties. United States: N. p., 2016. Web.
Ghosh, Kunal, Burns, Laurie, El Gamal, Abbas, Schnitzer, Mark J., Cocker, Eric, & Ho, Tatt Wei. Microscopy imaging device with advanced imaging properties. United States.
Ghosh, Kunal, Burns, Laurie, El Gamal, Abbas, Schnitzer, Mark J., Cocker, Eric, and Ho, Tatt Wei. Tue . "Microscopy imaging device with advanced imaging properties". United States. https://www.osti.gov/servlets/purl/1330343.
@article{osti_1330343,
title = {Microscopy imaging device with advanced imaging properties},
author = {Ghosh, Kunal and Burns, Laurie and El Gamal, Abbas and Schnitzer, Mark J. and Cocker, Eric and Ho, Tatt Wei},
abstractNote = {Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {10}
}

Works referenced in this record:

Blind Wiring Mach.
patent, March 1869


In vivo video camera system
patent, February 1997


Miniature scanning confocal microscope
patent, July 2000


Miniature microscope
patent, August 2000


Portable tissue spectroscopy apparatus and method
patent, November 2001


Encoded molecular sieve particle-based sensors
patent, September 2004


Capsule endoscope
patent, February 2005


Miniaturized microscope array digital slide scanner
patent, February 2007


Method and apparatus for high resolution coherent optical imaging
patent, July 2007


Micro-optical analysis system and approach therefor
patent, December 2007


Capsule endoscope and a capsule endoscope system
patent, January 2008


Compact fluorescence endoscopy video system
patent, March 2008


Light scanning microscope and use
patent, July 2009


Active CMOS biosensor chip for fluorescent-based detection
patent, June 2010


Ingestible device platform for the colon
patent, June 2011


Ingestible pill for diagnosing a gastrointestinal tract
patent, October 2011


Device and method for wide-field and high resolution imaging of tissue
patent, October 2011


Imaging apparatus and methods
patent, October 2012


Live being optical analysis system and approach
patent, July 2014


Vaccination by transcutaneous targeting
patent, February 2015


Microscopy imaging device with advanced imaging properties
patent, November 2015


Electrically induced vessel vasodilation
patent-application, February 2002


Calibration of fluorescence resonance energy transfer in microscopy
patent-application, August 2002


Microfabricated microbial growth assay method and apparatus
patent-application, December 2002


Surface plasmon enhanced illumination system
patent-application, February 2003


Spatial light modulator apparatus
patent-application, May 2003


Multimodal miniature microscope
patent-application, June 2003


Graded-index lens microscopes
patent-application, June 2003


Method for making microsensor arrays for detecting analytes
patent-application, September 2003


Fluorescence imaging endoscope
patent-application, October 2003


Imaging system with an integrated source and detector array
patent-application, December 2003


Method and apparatus for observing element distribution
patent-application, January 2004


Encoded molecular sieve particle-based sensors
patent-application, January 2004


Ingestible pill
patent-application, March 2004


Fluorescence correlation spectroscopy instrument and method of using the same
patent-application, April 2004


Therapeutic antiangiogenic compositions and methods
patent-application, May 2004


Miniaturized microscope array digital slide scanner
patent-application, May 2004


Device for observation of samples by fluorescence particularly sequentially
patent-application, June 2004


Imaging system, methodology, and applications employing reciprocal space optical design
patent-application, August 2004


Fluorescent virus probes for identification of bacteria
patent-application, September 2004


Lipid binding molecules and methods of use
patent-application, September 2004


Wireless in-vivo information acquiring system and external device
patent-application, October 2004


Wireless in-vivo information acquiring system and body-insertable device
patent-application, November 2004


Excitation and imaging of fluorescent arrays
patent-application, January 2005


Imaging system, methodology, and applications employing reciprocal space optical design
patent-application, February 2005


Examination systems for biological samples
patent-application,  


Oligonucleotide probe sets and uses thereof
patent-application, June 2005


Inspection system with auto-focus
patent-application, August 2005


Laser crystallization apparatus and laser crystallization method
patent-application, September 2005


Catadioptric imaging system exhibiting enhanced deep ultraviolet spectral bandwidth
patent-application, November 2005


Ingestible device platform for the colon
patent-application, December 2005


Activatable probes and methods for in vivo gene detection
patent-application, December 2005


Rapid haplotyping by single molecule detection
patent-application, January 2006


Depth-of-Field Micron Resolution Velocimetry with Pulsed Images of Injected Solid Particles
patent-application, March 2006


Slide-borne imaging instructions
patent-application, July 2007


Optical delivery systems and methods of providing adjustable beam diameter, spot size and/or spot shape
patent-application, August 2007


Spectral Unmixing for In-Vivo Imaging
patent-application, February 2008


Microfluidic flow cytometer and applications of same
patent-application, March 2008


Dynamic Scanning Automatic Microscope and Method
patent-application, July 2008


Miniature microscope camera
patent-application, August 2008


Method and System for Standardizing Microscope Instruments
patent-application, December 2008


Systems and methods for volumetric tissue scanning microscopy
patent-application, March 2009


Optical System and Method for Inspecting Fluorescently Labeled Biological Specimens
patent-application, June 2009


Methods and Devices for Orthovoltage Ocular Radiotherapy and Treatment Planning
patent-application, June 2009


Light Source
patent-application, August 2009


Automated Method for Detecting Cancers and High Grade Hyperplasias
patent-application, August 2009


Method and an Apparatus for Localization of Single Dye Molecules in the Fluorescent Microscopy
patent-application, September 2009


Mirror Adapted in Microscope to Perform SERS, a Microscope and Methods Thereof
patent-application, October 2009


System and Method for Large Field of View, Single Cell Analysis
patent-application, December 2009


Reconstruction and Visualization of Neuronal Cell Structures with Bright-Field Mosaic Microscopy
patent-application, March 2010


3D Medical Anatomical Image System Using 2D Images
patent-application, April 2010


Microscope for Virtual-Slide Creating System
patent-application, April 2010


Use of Reference Source with Adaptive Optics in Biological Microscopy
patent-application, April 2010


Devices and Methods for Optoelectronic Manipulation of Small Particles
patent-application, August 2010


Disposable Microscope and Portable Display
patent-application, August 2010


Method and Systems for Reducing Scanner Image Distortion
patent-application, October 2010


Confocal Photoacoustic Microscopy with Optical Lateral Resolution
patent-application, October 2010


Vaccination by Transcutaneous Targeting
patent-application, November 2010


Scanning Microscope Device
patent-application, November 2010


Methods and Devices for Orthovoltage Ocular Radiotherapy and Treatment Planning
patent-application, April 2011


Sensors for biomolecular detection and cell classification
patent-application, October 2011


Endoscope System
patent-application, December 2011


Microscopy Imaging Device with Advanced Imaging Properties
patent-application, March 2012


System for Synchronization in a Line Scanning Imaging Microscope
patent-application, April 2013


A genetic screen identifies genes essential for development of myelinated axons in zebrafish
journal, October 2006


The Cerebellum: A Neuronal Learning Machine?
journal, May 1996


Imaging performance of a miniature integrated microendoscope
journal, September 2008


Lensfree holographic imaging for on-chip cytometry and diagnostics
journal, January 2009


A Role for the Cerebellum in Learning Movement Coordination
journal, July 1998


Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
journal, November 2009


Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning
journal, January 2004


Dynamic organization of motor control within the olivocerebellar system
journal, March 1995


Advances in Light Microscopy for Neuroscience
journal, June 2009


The application of Fresnel zone plate based projection in optofluidic microscopy
journal, September 2008


Integrated semiconductor optical sensors for cellular and neural imaging
journal, April 2007


High-speed, miniaturized fluorescence microscopy in freely moving mice
journal, October 2008


Miniaturized integration of a fluorescence microscope
journal, September 2011


Digital camera system on a chip
journal, January 1998


CMOS image sensors: State-of-the-art
journal, September 2008


A Miniature Head-Mounted Two-Photon Microscope
journal, September 2001


Voltage sensitive dye imaging system for awake and freely moving animals
conference, November 2008


High-speed fluorescence imaging system for freely moving animals
conference, May 2009


Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices
journal, March 2010


Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice
journal, October 2007


In vivo brain imaging using a portable 29 g two-photon microscope based on a microelectromechanical systems scanning mirror
journal, August 2009


Visually evoked activity in cortical cells imaged in freely moving animals
journal, November 2009


Spatiotemporal Dynamics of Cortical Sensorimotor Integration in Behaving Mice
journal, December 2007


Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo
journal, January 2008


Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus
journal, August 1978


Complex spikes in Purkinje cells in the lateral vermis (b zone) of the cat cerebellum during locomotion.
journal, April 1987


Anatomical and physiological foundations of cerebellar information processing
journal, March 2005


Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy
journal, January 2011


Mobile Phone Based Clinical Microscopy for Global Health Applications
journal, July 2009



journal, January 2002


Temporal Structure of Receptor Neuron Input to the Olfactory Bulb Imaged in Behaving Rats
journal, February 2009


Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging
journal, July 2008


CMOS image sensors
journal, May 2005


Reliable Coding Emerges from Coactivation of Climbing Fibers in Microbands of Cerebellar Purkinje Neurons
journal, August 2009


In vivo brain imaging using a portable 39 gram two-photon fluorescence microendoscope
journal, September 2005


The isochronic band hypothesis and climbing fibre regulation of motricity: an experimental study: Global patterns of climbing fibre activity
journal, July 2009


Functional localization in the cerebellum
journal, January 2011


Microscopic marvels: Microscope for the masses
journal, June 2009


Optofluidic microscopy—a method for implementing a high resolution optical microscope on a chip
journal, January 2006


Functional organization of climbing fibre projection to the cerebellar anterior lobe of the rat
journal, January 2000


In Vivo Mammalian Brain Imaging Using One- and Two-Photon Fluorescence Microendoscopy
journal, November 2004


Arraycount, an algorithm for automatic cell counting in microwell arrays
journal, September 2009


Somatotopic studies on the vermal cortex of the cerebellar anterior lobe of unanaesthetized cats
journal, April 1977


Interpreting the BOLD Signal
journal, March 2004


erbb3 and erbb2 Are Essential for Schwann Cell Migration and Myelination in Zebrafish
journal, March 2005


A genetically encoded calcium indicator for chronic in vivo two-photon imaging
journal, August 2008


Automated Analysis of Cellular Signals from Large-Scale Calcium Imaging Data
journal, September 2009


Dendritic encoding of sensory stimuli controlled by deep cortical interneurons
journal, January 2009


Motor Behavior Activates Bergmann Glial Networks
journal, May 2009


Identification and Clustering of Event Patterns From In Vivo Multiphoton Optical Recordings of Neuronal Ensembles
journal, July 2008


High-throughput fluorescence microscopy for systems biology
journal, July 2006


Multiphoton endoscopy
journal, January 2003


In Vivo Multiphoton Microscopy of Deep Brain Tissue
journal, April 2004