Microscopy imaging device with advanced imaging properties

Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas; Schnitzer, Mark J.; Cocker, Eric; Ho, Tatt Wei

Title: Microscopy imaging device with advanced imaging properties

Abstract

Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.

Inventors:: Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas; Schnitzer, Mark J.; Cocker, Eric; Ho, Tatt Wei

Issue Date:: 2016-10-25

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1330343

Patent Number(s):: 9474448

Application Number:: 14/884,543

Assignee:: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B2090/306 - {using optical fibres}
A61B2503/40 - Animals
A61B2503/42 - for laboratory research
A61B2562/0233 - Special features of optical sensors or probes classified in A61B5/00
A61B2562/04 - Arrangements of multiple sensors of the same type
A61B2576/026 - for the brain
A61B5/0042 - {for the brain}
A61B5/0071 - {by measuring fluorescence emission}
A61B5/0082 - {adapted for particular medical purposes}
A61B5/489 - {Blood vessels}
A61B90/20 - Surgical microscopes characterised by non-optical aspects

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/6458 - {Fluorescence microscopy

G - PHYSICS G02 - OPTICS G02B - OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
G02B21/0008 - {Microscopes having a simple construction, e.g. portable microscopes}
G02B21/008 - {Details of detection or image processing, including general computer control}
G02B21/16 - adapted for ultra-violet illumination {
G02B21/36 - arranged for photographic purposes or projection purposes
G02B21/361 - {Optical details, e.g. image relay to the camera or image sensor
G02B21/362 - {Mechanical details, e.g. mountings for the camera or image sensor, housings
G02B21/365 - {Control or image processing arrangements for digital or video microscopes
G02B27/141 - {using dichroic mirrors}
G02B3/0087 - {with index gradient}

G - PHYSICS G06 - COMPUTING G06T - IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
G06T2207/30016 - Brain
G06T2207/30101 - Blood vessel
G06T7/0012 - {Biomedical image inspection}

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
G16H30/40 - for processing medical images, e.g. editing

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DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Oct 15

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Ghosh, Kunal, Burns, Laurie, El Gamal, Abbas, Schnitzer, Mark J., Cocker, Eric, and Ho, Tatt Wei. Microscopy imaging device with advanced imaging properties.  United States: N. p., 2016. 
        Web.

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                    Ghosh, Kunal, Burns, Laurie, El Gamal, Abbas, Schnitzer, Mark J., Cocker, Eric, & Ho, Tatt Wei. Microscopy imaging device with advanced imaging properties.  United States.

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                    Ghosh, Kunal, Burns, Laurie, El Gamal, Abbas, Schnitzer, Mark J., Cocker, Eric, and Ho, Tatt Wei. Tue .  
        "Microscopy imaging device with advanced imaging properties".  United States.  https://www.osti.gov/servlets/purl/1330343.

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@article{osti_1330343,

  title        = {Microscopy imaging device with advanced imaging properties},

  author       = {Ghosh, Kunal and Burns, Laurie and El Gamal, Abbas and Schnitzer, Mark J. and Cocker, Eric and Ho, Tatt Wei},

  abstractNote = {Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {10}

}

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