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Title: Long-range barcode labeling-sequencing

Methods for sequencing single large DNA molecules by clonal multiple displacement amplification using barcoded primers. Sequences are binned based on barcode sequences and sequenced using a microdroplet-based method for sequencing large polynucleotide templates to enable assembly of haplotype-resolved complex genomes and metagenomes.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1329319
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,469,874
Application Number:
13/653,343
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2012 Oct 16
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Comprehensive human genome amplification using multiple displacement amplification
journal, April 2002
  • Dean, F. B.; Hosono, S.; Fang, L.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 8, p. 5261-5266
  • DOI: 10.1073/pnas.082089499