.sup.100Mo compounds as accelerator targets for production of .sup.99mTc

Title: .sup.100Mo compounds as accelerator targets for production of .sup.99mTc

Abstract

Methods of synthesizing .sup.100Mo.sub.2C and .sup.99mTcO.sub.4.sup.- are disclosed. Methods of .sup.100Mo.sub.2C generation involve thermally carburizing .sup.100MoO.sub.3. Methods of .sup.99mTcO.sub.4 generation involve proton bombardment of .sup.100Mo.sub.2C in a cyclotron. Yields of .sup.99mTcO.sub.4 can be increased by sintering .sup.100Mo.sub.2C prior to bombardment. The methods also include recycling of .sup.100Mo.sub.2C to form .sup.100MoO.sub.3. SPECT images obtained using .sup.99mTcO.sub.4 generated by the disclosed methods are also presented.

Inventors:: Richards, Vernal; Lapi, Suzanne

Issue Date:: 2016-09-20

Research Org.:: Washington University, Saint Louis, MO (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1325736

Patent Number(s):: 9449726

Application Number:: 14/293,599

Assignee:: Washington University (Saint Louis, MO)

Patent Classifications (CPCs):: G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS

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G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G2001/0036 - {Molybdenum}
G21G1/001 - {Recovery of specific isotopes from irradiated targets}
G21G2001/0042 - {Technetium}

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS
C01B32/949 - Tungsten or molybdenum carbides

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K51/0489 - {Phosphates or phosphonates, e.g. bone-seeking phosphonates

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DOE Contract Number:: SC0006435

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 Jun 02

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Richards, Vernal, and Lapi, Suzanne. .sup.100Mo compounds as accelerator targets for production of .sup.99mTc.  United States: N. p., 2016. 
        Web.

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                    Richards, Vernal, & Lapi, Suzanne. .sup.100Mo compounds as accelerator targets for production of .sup.99mTc.  United States.

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                    Richards, Vernal, and Lapi, Suzanne. Tue .  
        ".sup.100Mo compounds as accelerator targets for production of .sup.99mTc".  United States.  https://www.osti.gov/servlets/purl/1325736.

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@article{osti_1325736,

  title        = {.sup.100Mo compounds as accelerator targets for production of .sup.99mTc},

  author       = {Richards, Vernal and Lapi, Suzanne},

  abstractNote = {Methods of synthesizing .sup.100Mo.sub.2C and .sup.99mTcO.sub.4.sup.- are disclosed. Methods of .sup.100Mo.sub.2C generation involve thermally carburizing .sup.100MoO.sub.3. Methods of .sup.99mTcO.sub.4 generation involve proton bombardment of .sup.100Mo.sub.2C in a cyclotron. Yields of .sup.99mTcO.sub.4 can be increased by sintering .sup.100Mo.sub.2C prior to bombardment. The methods also include recycling of .sup.100Mo.sub.2C to form .sup.100MoO.sub.3. SPECT images obtained using .sup.99mTcO.sub.4 generated by the disclosed methods are also presented.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {9}

}

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Works referenced in this record:

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Similar Records

Title: .sup.100Mo compounds as accelerator targets for production of .sup.99mTc

Abstract

Citation Formats

Clinical studies with spleen-specific radiolabeled agents journal, July 1985

Evolution of Tc-99m in diagnostic radiopharmaceuticals journal, October 2001

A Monte Carlo computer program for the transport of energetic ions in amorphous targets journal, August 1980

Advances in the production, processing and microPET image quality of technetium-94m journal, October 2006

Decomposition of molybdate–hexamethylenetetramine complex: One single source route for different catalytic materials journal, October 2011

99Mo/99mTc separation: An assessment of technology options journal, February 2013

Unparalleled Contribution of Technetium-99m to Medicine Over 5 Decades journal, March 2009

Cyclotron production of 99mTc: Experimental measurement of the 100Mo(p,x)99Mo, 99mTc and 99gTc excitation functions from 8 to 18 MeV journal, August 2011

Cyclotron production of 99mTc: Recycling of enriched 100Mo metal targets journal, August 2012

The structural and dynamical properties of Al clusters adsorbed on Ni surface journal, June 2001

Cyclotron production of NCA 99mTc and 99Mo. An alternative non-reactor supply source of instant 99mTc and 99Mo→99mTc generators journal, January 1991

Sustained Availability of 99mTc: Possible Paths Forward journal, December 2012

Excitation functions for the cyclotron production of 99mTc and 99Mo journal, July 1999

Synthesis of Bulk and Supported Molybdenum Carbide by a Single-Step Thermal Carburization Method journal, April 2007

Clinical studies with spleen-specific radiolabeled agents
journal, July 1985

Evolution of Tc-99m in diagnostic radiopharmaceuticals
journal, October 2001

A Monte Carlo computer program for the transport of energetic ions in amorphous targets
journal, August 1980

Advances in the production, processing and microPET image quality of technetium-94m
journal, October 2006

Decomposition of molybdate–hexamethylenetetramine complex: One single source route for different catalytic materials
journal, October 2011

⁹⁹Mo/^99mTc separation: An assessment of technology options
journal, February 2013

Unparalleled Contribution of Technetium-99m to Medicine Over 5 Decades
journal, March 2009

Cyclotron production of ^99mTc: Experimental measurement of the ¹⁰⁰Mo(p,x)⁹⁹Mo, ^99mTc and ^99gTc excitation functions from 8 to 18 MeV
journal, August 2011

Cyclotron production of ^99mTc: Recycling of enriched ¹⁰⁰Mo metal targets
journal, August 2012

The structural and dynamical properties of Al clusters adsorbed on Ni surface
journal, June 2001

Cyclotron production of NCA ^99mTc and ⁹⁹Mo. An alternative non-reactor supply source of instant ^99mTc and ⁹⁹Mo→^99mTc generators
journal, January 1991

Sustained Availability of 99mTc: Possible Paths Forward
journal, December 2012

Excitation functions for the cyclotron production of ^99mTc and ⁹⁹Mo
journal, July 1999

Synthesis of Bulk and Supported Molybdenum Carbide by a Single-Step Thermal Carburization Method
journal, April 2007