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Title: Fermentation process using specific oxygen uptake rates as a process control

Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1312649
Assignee:
Cargill Incorporated (Wayzata, MN) GFO
Patent Number(s):
9,428,776
Application Number:
14/479,309
Contract Number:
FC36-00GO10598
Resource Relation:
Patent File Date: 2014 Sep 06
Research Org:
Cargill Incorporated, Wayzata, MN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Large scale production of cyclohexanone monooxygenase from Escherichia coli TOP10 pQR239
journal, February 2001
  • O‚ÄôSullivan, Lisa M.; Patel, Sejal; Ward, John M.
  • Enzyme and Microbial Technology, Vol. 28, Issue 2-3, p. 265-274
  • DOI: 10.1016/S0141-0229(00)00320-3

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