Peptide and protein biomarkers for type 1 diabetes mellitus
Abstract
A method for identifying persons with increased risk of developing type 1 diabetes mellitus, or having type I diabetes mellitus, utilizing selected biomarkers described herein either alone or in combination. The present disclosure allows for broad based, reliable, screening of large population bases. Also provided are arrays and kits that can be used to perform such methods.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1311866
- Patent Number(s):
- 9429569
- Application Number:
- 14/268,002
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 May 02
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Zhang, Qibin, and Metz, Thomas O. Peptide and protein biomarkers for type 1 diabetes mellitus. United States: N. p., 2016.
Web.
Zhang, Qibin, & Metz, Thomas O. Peptide and protein biomarkers for type 1 diabetes mellitus. United States.
Zhang, Qibin, and Metz, Thomas O. Tue .
"Peptide and protein biomarkers for type 1 diabetes mellitus". United States. https://www.osti.gov/servlets/purl/1311866.
@article{osti_1311866,
title = {Peptide and protein biomarkers for type 1 diabetes mellitus},
author = {Zhang, Qibin and Metz, Thomas O.},
abstractNote = {A method for identifying persons with increased risk of developing type 1 diabetes mellitus, or having type I diabetes mellitus, utilizing selected biomarkers described herein either alone or in combination. The present disclosure allows for broad based, reliable, screening of large population bases. Also provided are arrays and kits that can be used to perform such methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 30 00:00:00 EDT 2016},
month = {Tue Aug 30 00:00:00 EDT 2016}
}
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Works referenced in this record:
Method for identifying type I diabetes mellitus in humans
patent-application, May 2009
- Metz, Thomas O.; Qian, Weijun; Jacobs, Jon M.
- US Patent Application 12/291173; 20090117578
Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseaes
patent-application, March 2012
- Chance, Mark; Cooke, Kenneth; Schlatzer, Daniela
- US Patent Application 13/375523; 20120077209
Composition and Methods for Diagnosis and Prognosis of Colorectal Cancer
patent-application, June 2012
- Aw, Eva I-Wei
- US Patent Application 13/148881; 20120149022
Methods for Detecting Pre-Diabetes and Diabetes Using Differential Protein Glycosylation
patent-application, August 2012
- Nagalia, Srinivasa R.; Roberts, Charles T.
- US Patent Application 13/457243; 20120208218
Quantitative Mass Spectrometric Multiple Reaction Monitoring Assays for Major Plasma Proteins
journal, December 2005
- Anderson, Leigh; Hunter, Christie L.
- Molecular & Cellular Proteomics, Vol. 5, Issue 4
Prediction of Autoantibody Positivity and Progression to Type 1 Diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
journal, August 2004
- Barker, Jennifer M.; Barriga, Katherine J.; Yu, Liping
- The Journal of Clinical Endocrinology & Metabolism, Vol. 89, Issue 8
Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation
journal, May 2003
- Bingley, P. J.; Bonifacio, E.; Mueller, P. W.
- Diabetes, Vol. 52, Issue 5
Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories
journal, July 2010
- Bingley, Polly J.; Williams, Alistair JK; Colman, Peter G.
- Clinical Trials: Journal of the Society for Clinical Trials, Vol. 7, Issue 1_suppl
Plasma Gelsolin: Function, Prognostic Value, and Potential Therapeutic Use
journal, December 2008
- Bucki, Robert; Levental, Ilya; Kulakowska, Alina
- Current Protein & Peptide Science, Vol. 9, Issue 6
Normalization Approaches for Removing Systematic Biases Associated with Mass Spectrometry and Label-Free Proteomics
journal, February 2006
- Callister, Stephen J.; Barry, Richard C.; Adkins, Joshua N.
- Journal of Proteome Research, Vol. 5, Issue 2
Type 1 diabetes: entering the proteomic era
journal, April 2006
- D’Hertog, Wannes; Mathieu, Chantal; Overbergh, Lut
- Expert Review of Proteomics, Vol. 3, Issue 2
Proteomics and naturally occurring animal diseases: Opportunities for animal and human medicine
journal, February 2008
- Doherty, Mary K.; Beynon, Robert J.; Whitfield, Phillip D.
- PROTEOMICS – CLINICAL APPLICATIONS, Vol. 2, Issue 2
Development of a fibrinogen-specific sandwich enzyme-linked immunosorbent assay microarray assay for distinguishing between blood plasma and serum samples
journal, July 2011
- Gonzalez, Rachel M.; Zhang, Qibin; Zangar, Richard C.
- Analytical Biochemistry, Vol. 414, Issue 1, p. 99-102
The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants
journal, May 2011
- Hagopian, William A.; Erlich, Henry; Lernmark, Åke
- Pediatric Diabetes, Vol. 12, Issue 8
Comparative aspects of diabetes mellitus in dogs and cats
journal, November 2002
- Hoenig, M.
- Molecular and Cellular Endocrinology, Vol. 197, Issue 1-2
High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance
journal, August 2008
- Hortin, G. L.; Sviridov, D.; Anderson, N. L.
- Clinical Chemistry, Vol. 54, Issue 10
Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data
journal, January 2009
- Jaitly, Navdeep; Mayampurath, Anoop; Littlefield, Kyle
- BMC Bioinformatics, Vol. 10, Issue 1
Environmental Triggers and Determinants of Type 1 Diabetes
journal, November 2005
- Knip, M.; Veijola, R.; Virtanen, S. M.
- Diabetes, Vol. 54, Issue Supplement 2
Thrombocidins, Microbicidal Proteins from Human Blood Platelets, Are C-terminal Deletion Products of CXC Chemokines
journal, June 2000
- Krijgsveld, Jeroen; Zaat, Sebastian A. J.; Meeldijk, Jan
- Journal of Biological Chemistry, Vol. 275, Issue 27
Multiple Reaction Monitoring-based, Multiplexed, Absolute Quantitation of 45 Proteins in Human Plasma
journal, May 2009
- Kuzyk, Michael A.; Smith, Derek; Yang, Juncong
- Molecular & Cellular Proteomics, Vol. 8, Issue 8
Potentiation of C1 Esterase Inhibitor by StcE, a Metalloprotease Secreted by Escherichia coli O157:H7
journal, April 2004
- Lathem, Wyndham W.; Bergsbaken, Tessa; Welch, Rodney A.
- The Journal of Experimental Medicine, Vol. 199, Issue 8
Fully Automated Four-Column Capillary LC−MS System for Maximizing Throughput in Proteomic Analyses
journal, January 2008
- Livesay, Eric A.; Tang, Keqi; Taylor, Beverley K.
- Analytical Chemistry, Vol. 80, Issue 1
Effect of Collision Energy Optimization on the Measurement of Peptides by Selected Reaction Monitoring (SRM) Mass Spectrometry
journal, December 2010
- MacLean, Brendan; Tomazela, Daniela M.; Abbatiello, Susan E.
- Analytical Chemistry, Vol. 82, Issue 24
Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset
journal, February 2008
- Metz, Thomas O.; Qian, Wei-Jun; Jacobs, Jon M.
- Journal of Proteome Research, Vol. 7, Issue 2
VIPER: an advanced software package to support high-throughput LC-MS peptide identification
journal, June 2007
- Monroe, Matthew E.; Tolić, Nikola; Jaitly, Navdeep
- Bioinformatics, Vol. 23, Issue 15
Interpretation of Shotgun Proteomic Data: The Protein Inference Problem
journal, July 2005
- Nesvizhskii, Alexey I.; Aebersold, Ruedi
- Molecular & Cellular Proteomics, Vol. 4, Issue 10
Improved Peptide Elution Time Prediction for Reversed-Phase Liquid Chromatography-MS by Incorporating Peptide Sequence Information
journal, July 2006
- Petritis, Konstantinos; Kangas, Lars J.; Yan, Bo
- Analytical Chemistry, Vol. 78, Issue 14
Primer: Immunity and Autoimmunity
journal, October 2008
- Pietropaolo, M.; Surhigh, J. M.; Nelson, P. W.
- Diabetes, Vol. 57, Issue 11
Targeted proteomic strategy for clinical biomarker discovery
journal, December 2008
- Schiess, Ralph; Wollscheid, Bernd; Aebersold, Ruedi
- Molecular Oncology, Vol. 3, Issue 1, p. 33-44
Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies
journal, September 2010
- Schlosser, M.; Mueller, P. W.; Törn, C.
- Diabetologia, Vol. 53, Issue 12
Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome
journal, February 2011
- Schutzer, Steven E.; Angel, Thomas E.; Liu, Tao
- PLoS ONE, Vol. 6, Issue 2
Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)
journal, September 2010
- Stene, L. C.; Oikarinen, S.; Hyoty, H.
- Diabetes, Vol. 59, Issue 12
Insulin-Dependent Diabetes Mellitus
journal, May 1996
- Tisch, Roland; McDevitt, Hugh
- Cell, Vol. 85, Issue 3
Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2
journal, March 2008
- Törn, C.; Mueller, P. W.; Schlosser, M.
- Diabetologia, Vol. 51, Issue 5
An Inflammatory Gene-Expression Fingerprint in Monocytes of Autoimmune Thyroid Disease Patients
journal, April 2010
- van der Heul-Nieuwenhuijsen, Leonie; Padmos, Roos C.; Drexhage, Roosmarijn C.
- The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 4
Prediction of Low-Energy Collision-Induced Dissociation Spectra of Peptides
journal, July 2004
- Zhang, Zhongqi
- Analytical Chemistry, Vol. 76, Issue 14
Advances in proteomics data analysis and display using an accurate mass and time tag approach
journal, January 2006
- Zimmer, Jennifer S. D.; Monroe, Matthew E.; Qian, Wei-Jun
- Mass Spectrometry Reviews, Vol. 25, Issue 3