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Title: Method for genetic identification of unknown organisms

A method of rapid, genome and proteome based identification of unknown pathogenic or non-pathogenic organisms in a complex sample. The entire sample is analyzed by creating millions of emulsion encapsulated microdroplets, each containing a single pathogenic or non-pathogenic organism sized particle and appropriate reagents for amplification. Following amplification, the amplified product is analyzed.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1303664
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) LLNL
Patent Number(s):
9,422,586
Application Number:
11/818,623
Contract Number:
W-7405-ENG-48
Resource Relation:
Patent File Date: 2007 Jun 15
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Chemical amplification based on fluid partitioning
patent, May 2006

Amplification of complex gene libraries by emulsion PCR
journal, July 2006
  • Williams, Richard; Peisajovich, Sergio G.; Miller, Oliver J.
  • Nature Methods, Vol. 3, Issue 7, p. 545-550
  • DOI: 10.1038/nmeth896

Single-molecule PCR using water-in-oil emulsion
journal, April 2003
  • Nakano, Michihiko; Komatsu, Jun; Matsuura, Shun-ichi
  • Journal of Biotechnology, Vol. 102, Issue 2, p. 117-124
  • DOI: 10.1016/S0168-1656(03)00023-3

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