Peptides having reduced toxicity that stimulate cholesterol efflux

Bielicki, John K.; Johansson, Jan; Danho, Waleed

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
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A42 - headwear
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A99 - subject matter not otherwise provided for in this section
B - performing operations
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Title: Peptides having reduced toxicity that stimulate cholesterol efflux

Abstract

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

Inventors:: Bielicki, John K.; Johansson, Jan; Danho, Waleed

Issue Date:: 2016-08-16

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1298004

Patent Number(s):: 9416162

Application Number:: 14/216,749

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/17 - from animals
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K47/544 - {Phospholipids}
A61K47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P13/12 - of the kidneys
A61P25/28 - for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P29/00 - Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents
A61P3/06 - Antihyperlipidemics
A61P3/10 - for hyperglycaemia, e.g. antidiabetics
A61P9/00 - Drugs for disorders of the cardiovascular system
A61P9/04 - Inotropic agents, i.e. stimulants of cardiac contraction
A61P9/10 - for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/435 - from animals
C07K14/775 - Apolipopeptides

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DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 Mar 17

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Bielicki, John K., Johansson, Jan, and Danho, Waleed. Peptides having reduced toxicity that stimulate cholesterol efflux.  United States: N. p., 2016. 
        Web.

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                    Bielicki, John K., Johansson, Jan, & Danho, Waleed. Peptides having reduced toxicity that stimulate cholesterol efflux.  United States.

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                    Bielicki, John K., Johansson, Jan, and Danho, Waleed. Tue .  
        "Peptides having reduced toxicity that stimulate cholesterol efflux".  United States.  https://www.osti.gov/servlets/purl/1298004.

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@article{osti_1298004,

  title        = {Peptides having reduced toxicity that stimulate cholesterol efflux},

  author       = {Bielicki, John K. and Johansson, Jan and Danho, Waleed},

  abstractNote = {The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {8}

}

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Works referenced in this record:

Cysteine-containing peptides having antioxidant properties
patent, October 2009

Bielicki, John K.
US Patent Document 7,601,802
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7601802

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent, April 2010

Bielicki, John K.; Natarajan, Pradeep
US Patent Document 7,691,965
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7691965

Methods and reagents for modulating cholesterol levels
patent-application, March 2004

Hayden, Michael R.; Wilson, Angela R. Brooks; Pimstone, Simon N.
US Patent Application 10/617334; 20040058869
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040058869

Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
patent-application, July 2005

Sircar, Jagadish C.; Alisala, Kashinatham; Nikoulin, Igor
US Patent Application 10/975157; 20050159362
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050159362

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent-application, September 2005

Bielicki, John K.; Natarajan, Pradeep
US Patent Application 11/014187; 20050202532
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050202532

Stabilized alpha helical peptides and uses thereof
patent-application, November 2005

Walensky, Loren D.; Korsmeyer, Stanley J.; Korsmeyer, Susan
US Patent Application 10/981873; 20050250680
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050250680

Orally administered peptides synergize statin activity
patent-application, April 2008

Fogelman, Alan M.; Anantharamaiah, Gattadahalli M.; Navab, Mohamad
US Patent Application 11/830675; 20080096815
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080096815

Compositions and methods of use for treating cardiovascular disease
patent-application, September 2008

Heinecke, Jay W.; Oram, John F.; Oda, Michael N.
US Patent Application 11/952044; 20080234192
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080234192

Diagnosis and treatment of reverse cholesterol transport deficiency-related diseases
patent-application, June 2011

Johansson, Jan O.
US Patent Application 12/976024; 20110152112
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110152112

Peptides Having Reduced Toxicity Thar Stimulate Cholesterol Efflux
patent-application, September 2014

Bielicki, John K.; Johansson, Jan; Danho, Waleed
US Patent Application 14/216749; 20140287994
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140287994

Protein Folding: A Glimpse of the Holy Grail?
journal, October 1998

Berendsen, H. J. C.
Science, Vol. 282, Issue 5389, p. 642-643
https://doi.org/10.1126/science.282.5389.642

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Bradley, Christina Marchetti; Barrick, Doug
Journal of Molecular Biology, Vol. 324, Issue 2, p. 373-386
https://doi.org/10.1016/S0022-2836(02)00945-2

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Ngo, J. Thomas; Marks, Joe; Karplus, Martin
The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
https://doi.org/10.1007/978-1-4684-6831-1_14

The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)
journal, July 2008

Pierce, Elizabeth; Xie, Gary; Barabote, Ravi D.
Environmental Microbiology, Vol. 10, Issue 10, p. 2550-2573
https://doi.org/10.1111/j.1462-2920.2008.01679.x

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
journal, February 2002

Ramprasad, Mysore P.; Anantharamaiah, G. M.; Garber, David W.
Journal of Controlled Release, Vol. 79, Issue 1-3, p. 207-218
https://doi.org/10.1016/S0168-3659(01)00552-1

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Rudinger, J.; Parsons, J. A.
Peptide Hormones, p. 1-7
https://doi.org/10.1007/978-1-349-02718-7_1

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004

Song, Yun Mi; Yang, Sung-Tae; Lim, Shin Saeng
Biochemical and Biophysical Research Communications, Vol. 314, Issue 2, p. 615-621
https://doi.org/10.1016/j.bbrc.2003.12.142

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus
journal, February 1992

Sparrow, James T.; Sparrow, Doris A.; Fernando, Germain
Biochemistry, Vol. 31, Issue 4, p. 1065-1068
https://doi.org/10.1021/bi00119a015

The C-Terminal Lipid-Binding Domain of Apolipoprotein E Is a Highly Efficient Mediator of ABCA1-Dependent Cholesterol Efflux that Promotes the Assembly of High-Density Lipoproteins
journal, March 2007

Vedhachalam, Charulatha; Narayanaswami, Vasanthy; Neto, Nicole
Biochemistry, Vol. 46, Issue 10, p. 2583-2593
https://doi.org/10.1021/bi602407r

Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux
journal, July 2003

Wang, N.
Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 23, Issue 7, p. 1178-1184
https://doi.org/10.1161/01.ATV.0000075912.83860.26

Similar Records in DOE Patents and OSTI.GOV collections:

Peptides having reduced toxicity that stimulate cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer'smore » Disease or frontotemporal dementia. « less
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Peptides having reduced toxicity that stimulate cholesterol efflux

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The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer'smore » Disease or frontotemporal dementia. « less
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Peptides having reduced toxicity that stimulate cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer'smore » Disease or frontotemporal dementia. « less
Full Text Available
Peptides having reduced toxicity that stimulate cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimersmore » Disease or frontotemporal dementia. « less
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Similar Records

Title: Peptides having reduced toxicity that stimulate cholesterol efflux

Abstract

Citation Formats

Cysteine-containing peptides having antioxidant properties patent, October 2009

Helical synthetic peptides that stimulate cellular cholesterol efflux patent, April 2010

Methods and reagents for modulating cholesterol levels patent-application, March 2004

Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia patent-application, July 2005

Helical synthetic peptides that stimulate cellular cholesterol efflux patent-application, September 2005

Stabilized alpha helical peptides and uses thereof patent-application, November 2005

Orally administered peptides synergize statin activity patent-application, April 2008

Compositions and methods of use for treating cardiovascular disease patent-application, September 2008

Diagnosis and treatment of reverse cholesterol transport deficiency-related diseases patent-application, June 2011

Peptides Having Reduced Toxicity Thar Stimulate Cholesterol Efflux patent-application, September 2014

Protein Folding: A Glimpse of the Holy Grail? journal, October 1998

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat journal, November 2002

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum) journal, July 2008

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels journal, February 2002

Characteristics of the amino acids as components of a peptide hormone sequence book, January 1976

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity journal, February 2004

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus journal, February 1992

The C-Terminal Lipid-Binding Domain of Apolipoprotein E Is a Highly Efficient Mediator of ABCA1-Dependent Cholesterol Efflux that Promotes the Assembly of High-Density Lipoproteins journal, March 2007

Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux journal, July 2003

Cysteine-containing peptides having antioxidant properties
patent, October 2009

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent, April 2010

Methods and reagents for modulating cholesterol levels
patent-application, March 2004

Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
patent-application, July 2005

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent-application, September 2005

Stabilized alpha helical peptides and uses thereof
patent-application, November 2005

Orally administered peptides synergize statin activity
patent-application, April 2008

Compositions and methods of use for treating cardiovascular disease
patent-application, September 2008

Diagnosis and treatment of reverse cholesterol transport deficiency-related diseases
patent-application, June 2011

Peptides Having Reduced Toxicity Thar Stimulate Cholesterol Efflux
patent-application, September 2014

Protein Folding: A Glimpse of the Holy Grail?
journal, October 1998

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)
journal, July 2008

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
journal, February 2002

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus
journal, February 1992

The C-Terminal Lipid-Binding Domain of Apolipoprotein E Is a Highly Efficient Mediator of ABCA1-Dependent Cholesterol Efflux that Promotes the Assembly of High-Density Lipoproteins
journal, March 2007

Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux
journal, July 2003