Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
Abstract
A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.
- Inventors:
- Issue Date:
- Research Org.:
- Idaho National Lab. (INL), Idaho Falls, ID (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1290004
- Patent Number(s):
- 9410965
- Application Number:
- 12/883,002
- Assignee:
- Battelle Energy Alliance, LLC (Idaho Falls, ID)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC07-05ID14517
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Sep 15
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Apel, William A., Thompson, Vicki S, Lacey, Jeffrey A., and Gentillon, Cynthia A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States: N. p., 2016.
Web.
Apel, William A., Thompson, Vicki S, Lacey, Jeffrey A., & Gentillon, Cynthia A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States.
Apel, William A., Thompson, Vicki S, Lacey, Jeffrey A., and Gentillon, Cynthia A. Tue .
"Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual". United States. https://www.osti.gov/servlets/purl/1290004.
@article{osti_1290004,
title = {Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual},
author = {Apel, William A. and Thompson, Vicki S and Lacey, Jeffrey A. and Gentillon, Cynthia A.},
abstractNote = {A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {8}
}
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