Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual

Title: Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual

A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.

Inventors:: Apel, William A.; Thompson, Vicki S; Lacey, Jeffrey A.; Gentillon, Cynthia A.

Issue Date:: 2016-08-09

OSTI Identifier:: 1290004

Assignee:: Battelle Energy Alliance, LLC (Idaho Falls, ID) INL

Patent Number(s):: 9,410,965

Application Number:: 12/883,002

Contract Number:: AC07-05ID14517

Resource Relation:: Patent File Date: 2010 Sep 15

Research Org:: Idaho National Lab. (INL), Idaho Falls, ID (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

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