Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences
Abstract
An apparatus for chip-based sorting, amplification, detection, and identification of a sample having a planar substrate. The planar substrate is divided into cells. The cells are arranged on the planar substrate in rows and columns. Electrodes are located in the cells. A micro-reactor maker produces micro-reactors containing the sample. The micro-reactor maker is positioned to deliver the micro-reactors to the planar substrate. A microprocessor is connected to the electrodes for manipulating the micro-reactors on the planar substrate. A detector is positioned to interrogate the sample contained in the micro-reactors.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1289941
- Patent Number(s):
- 9409177
- Application Number:
- 12/401,714
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2009 Mar 11
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION
Citation Formats
Beer, Neil Reginald, and Colston, Jr, Billy W. Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences. United States: N. p., 2016.
Web.
Beer, Neil Reginald, & Colston, Jr, Billy W. Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences. United States.
Beer, Neil Reginald, and Colston, Jr, Billy W. Tue .
"Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences". United States. https://www.osti.gov/servlets/purl/1289941.
@article{osti_1289941,
title = {Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences},
author = {Beer, Neil Reginald and Colston, Jr, Billy W.},
abstractNote = {An apparatus for chip-based sorting, amplification, detection, and identification of a sample having a planar substrate. The planar substrate is divided into cells. The cells are arranged on the planar substrate in rows and columns. Electrodes are located in the cells. A micro-reactor maker produces micro-reactors containing the sample. The micro-reactor maker is positioned to deliver the micro-reactors to the planar substrate. A microprocessor is connected to the electrodes for manipulating the micro-reactors on the planar substrate. A detector is positioned to interrogate the sample contained in the micro-reactors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {8}
}
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Works referenced in this record:
Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
patent-application, July 2008
- Beer, Neil; Hindson, Benjamin; Colson, Billy
- US Patent Application 11/650363; 20080166793
Droplet-based chemistry on a programmable micro-chip
journal, January 2004
- Schwartz, Jon A.; Vykoukal, Jody V.; Gascoyne, Peter R. C.
- Lab on a Chip, Vol. 4, Issue 1
Dielectrophoresis-based programmable fluidic processors
journal, January 2004
- Gascoyne, Peter R. C.; Vykoukal, Jody V.; Schwartz, Jon A.
- Lab on a Chip, Vol. 4, Issue 4