Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry

Title: Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry

Technologies related to identification of a substance in an optimized manner are provided. A reference group of known materials is identified. Each known material has known values for several classification parameters. The classification parameters comprise at least one of T.sub.1, T.sub.2, T.sub.1.rho., a relative nuclear susceptibility (RNS) of the substance, and an x-ray linear attenuation coefficient (LAC) of the substance. A measurement sequence is optimized based on at least one of a measurement cost of each of the classification parameters and an initial probability of each of the known materials in the reference group.

Inventors:: Espy, Michelle A.; Matlashov, Andrei N.; Schultz, Larry J.; Volegov, Petr L.

Issue Date:: 2016-08-09

OSTI Identifier:: 1288655

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM) LANL

Patent Number(s):: 9,411,031

Application Number:: 13/869,718

Contract Number:: AC52-06NA25396

Resource Relation:: Patent File Date: 2013 Apr 24

Research Org:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

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Other works cited in this record:

Zeugmatography process
patent, June 1983

Ganssen, Alexander; Oppelt, Arnulf; Loeffler, Wilfried
US Patent Document 4,390,840
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/4390840

Method and apparatus for measuring the distribution of elements contained in sample
patent, January 1997

Obori, Kenichi; Bando, Atsushi; Yurugi, Toshikazu
US Patent Document 5,596,195
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/5596195

Apparatus and method for generating short pulses for NMR and NQR processing
patent, September 1998

Miller, Joel; Garroway, Allen
US Patent Document 5,804,967
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/5804967

Temperature compensated magnetic field apparatus for NMR measurements
patent, June 2003

Prammer, Manfred; Masak, Peter
US Patent Document 6,577,125
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6577125

Method and apparatus for high resolution ex-situ NMR spectroscopy
patent, January 2004

Pines, Alexander; Meriles, Carlos; Heise, Henrike
US Patent Document 6,674,282
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6674282

Method of multivariate spectral analysis
patent, January 2004

Keenan, Michael; Kotula, Paul
US Patent Document 6,675,106
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6675106

Nuclear resonance based scanning system having an automatic object identification and attribute information acquisition and linking mechanism integrated therein
patent, June 2006

Knowles, C. Harry; Schmidt, Mark; Fisher, Dale
US Patent Document 7,059,524
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7059524

Remote NMR/MRI detection of laser polarized gases
patent, June 2006

Pines, Alexander; Saxena, Sunil; Moule, Adam
US Patent Document 7,061,237
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7061237

NMR and MRI apparatus and method
patent, March 2007

Clarke, John; Kelso, Nathan; Lee, SeungKyun
US Patent Document 7,187,169
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7187169

Method and apparatus for detecting contraband using radiated compound signatures
patent, July 2007

Smith, Richard
US Patent Document 7,251,310
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7251310

Mine detector with NQR-SQUID
patent, July 2008

Itozaki, Hideo; Kawagishi, Kyoko; Kondo, Tadayuki
US Patent Document 7,394,250
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7394250

Method for determining the content of at least one component of a sample by means of a nuclear magnetic resonance pulse spectrometer
patent, July 2008

Gauthausen, Gisela; Kamlowski, Andreas; Schmalbein, Dieter
US Patent Document 7,397,241
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7397241

Method for molecule examination by NMR spectroscopy
patent, June 2009

Appelt, Stephan; Kuhn, Holger; Sieling, Ulrich
US Patent Document 7,541,806
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7541806

Direct imaging of neural currents using ultra-low field magnetic resonance techniques
patent, August 2009

Volegov, Petr; Matlashov, Andrei; Mosher, John
US Patent Document 7,573,268
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7573268

Ultra-low field nuclear magnetic resonance and magnetic resonance imaging to discriminate and identify materials
patent, March 2010

Kraus, Robert; Matlashov, Andrei; Espy, Michelle
US Patent Document 7,688,069
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7688069

Noise cancellation in magnetoencephalography and electroencephalography with isolated reference sensors
patent, June 2010

Kraus, Robert; Espy, Michelle; Matlachov, Andrei
US Patent Document 7,729,740
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7729740

Method, a processor, and a system for identifying a substance
patent, July 2010

Harding, Geoffrey
US Patent Document 7,764,764
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7764764

Toward direct mapping of neuronal activity: MRI detection of ultraweak, transient magnetic field changes
journal, June 2002

Bodurka, Jerzy; Bandettini, Peter A.
Magnetic Resonance in Medicine, Vol. 47, Issue 6, p. 1052-1058
DOI: 10.1002/mrm.10159

SQUID detected NMR in microtesla magnetic fields
journal, September 2004

Matlachov, Andrei N.; Volegov, Petr L.; Espy, Michelle A.
Journal of Magnetic Resonance, Vol. 170, Issue 1, p. 1-7
DOI: 10.1016/j.jmr.2004.05.015

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
journal, August 2003

Xiong, Jinhu; Fox, Peter T.; Gao, Jia-Hong
Human Brain Mapping, Vol. 20, Issue 1, p. 41-49
DOI: 10.1002/hbm.10124

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