Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry

Title: Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry

Abstract

Technologies related to identification of a substance in an optimized manner are provided. A reference group of known materials is identified. Each known material has known values for several classification parameters. The classification parameters comprise at least one of T.sub.1, T.sub.2, T.sub.1.rho., a relative nuclear susceptibility (RNS) of the substance, and an x-ray linear attenuation coefficient (LAC) of the substance. A measurement sequence is optimized based on at least one of a measurement cost of each of the classification parameters and an initial probability of each of the known materials in the reference group.

Inventors:: Espy, Michelle A.; Matlashov, Andrei N.; Schultz, Larry J.; Volegov, Petr L.

Issue Date:: 2016-08-09

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1288655

Patent Number(s):: 9411031

Application Number:: 13/869,718

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N24/084 - {Detection of potentially hazardous samples, e.g. toxic samples, explosives, drugs, firearms, weapons}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/448 - {Relaxometry, i.e. quantification of relaxation times or spin density
G01R33/44 - using nuclear magnetic resonance [NMR]

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DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2013 Apr 24

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats


                    Espy, Michelle A., Matlashov, Andrei N., Schultz, Larry J., and Volegov, Petr L. Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry.  United States: N. p., 2016. 
        Web.

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                    Espy, Michelle A., Matlashov, Andrei N., Schultz, Larry J., & Volegov, Petr L. Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry.  United States.

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                    Espy, Michelle A., Matlashov, Andrei N., Schultz, Larry J., and Volegov, Petr L. Tue .  
        "Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry".  United States.  https://www.osti.gov/servlets/purl/1288655.

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@article{osti_1288655,

  title        = {Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry},

  author       = {Espy, Michelle A. and Matlashov, Andrei N. and Schultz, Larry J. and Volegov, Petr L.},

  abstractNote = {Technologies related to identification of a substance in an optimized manner are provided. A reference group of known materials is identified. Each known material has known values for several classification parameters. The classification parameters comprise at least one of T.sub.1, T.sub.2, T.sub.1.rho., a relative nuclear susceptibility (RNS) of the substance, and an x-ray linear attenuation coefficient (LAC) of the substance. A measurement sequence is optimized based on at least one of a measurement cost of each of the classification parameters and an initial probability of each of the known materials in the reference group.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2016},

  month        = {8}

}

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Works referenced in this record:

Zeugmatography process
patent, June 1983

Ganssen, Alexander; Oppelt, Arnulf; Loeffler, Wilfried
US Patent Document 4,390,840
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/4390840

Method and apparatus for measuring the distribution of elements contained in sample
patent, January 1997

Obori, Kenichi; Bando, Atsushi; Yurugi, Toshikazu
US Patent Document 5,596,195
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/5596195

Apparatus and method for generating short pulses for NMR and NQR processing
patent, September 1998

Miller, Joel; Garroway, Allen
US Patent Document 5,804,967
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/5804967

Temperature compensated magnetic field apparatus for NMR measurements
patent, June 2003

Prammer, Manfred; Masak, Peter
US Patent Document 6,577,125
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6577125

Method and apparatus for high resolution ex-situ NMR spectroscopy
patent, January 2004

Pines, Alexander; Meriles, Carlos; Heise, Henrike
US Patent Document 6,674,282
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6674282

Method of multivariate spectral analysis
patent, January 2004

Keenan, Michael; Kotula, Paul
US Patent Document 6,675,106
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6675106

Nuclear resonance based scanning system having an automatic object identification and attribute information acquisition and linking mechanism integrated therein
patent, June 2006

Knowles, C. Harry; Schmidt, Mark; Fisher, Dale
US Patent Document 7,059,524
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7059524

Remote NMR/MRI detection of laser polarized gases
patent, June 2006

Pines, Alexander; Saxena, Sunil; Moule, Adam
US Patent Document 7,061,237
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7061237

NMR and MRI apparatus and method
patent, March 2007

Clarke, John; Kelso, Nathan; Lee, SeungKyun
US Patent Document 7,187,169
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7187169

Method and apparatus for detecting contraband using radiated compound signatures
patent, July 2007

Smith, Richard
US Patent Document 7,251,310
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7251310

Mine detector with NQR-SQUID
patent, July 2008

Itozaki, Hideo; Kawagishi, Kyoko; Kondo, Tadayuki
US Patent Document 7,394,250
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7394250

Method for determining the content of at least one component of a sample by means of a nuclear magnetic resonance pulse spectrometer
patent, July 2008

Gauthausen, Gisela; Kamlowski, Andreas; Schmalbein, Dieter
US Patent Document 7,397,241
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7397241

Method for molecule examination by NMR spectroscopy
patent, June 2009

Appelt, Stephan; Kuhn, Holger; Sieling, Ulrich
US Patent Document 7,541,806
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7541806

Direct imaging of neural currents using ultra-low field magnetic resonance techniques
patent, August 2009

Volegov, Petr; Matlashov, Andrei; Mosher, John
US Patent Document 7,573,268
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7573268

Ultra-low field nuclear magnetic resonance and magnetic resonance imaging to discriminate and identify materials
patent, March 2010

Kraus, Robert; Matlashov, Andrei; Espy, Michelle
US Patent Document 7,688,069
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7688069

Noise cancellation in magnetoencephalography and electroencephalography with isolated reference sensors
patent, June 2010

Kraus, Robert; Espy, Michelle; Matlachov, Andrei
US Patent Document 7,729,740
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7729740

Method, a processor, and a system for identifying a substance
patent, July 2010

Harding, Geoffrey
US Patent Document 7,764,764
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/7764764

Toward direct mapping of neuronal activity: MRI detection of ultraweak, transient magnetic field changes
journal, June 2002

Bodurka, Jerzy; Bandettini, Peter A.
Magnetic Resonance in Medicine, Vol. 47, Issue 6, p. 1052-1058
https://doi.org/10.1002/mrm.10159

SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields
journal, June 2005

Espy, M. A.; Matlachov, A. N.; Volegov, P. L.
IEEE Transactions on Appiled Superconductivity, Vol. 15, Issue 2
https://doi.org/10.1109/TASC.2005.849978

SQUID detected NMR in microtesla magnetic fields
journal, September 2004

Matlachov, Andrei N.; Volegov, Petr L.; Espy, Michelle A.
Journal of Magnetic Resonance, Vol. 170, Issue 1, p. 1-7
https://doi.org/10.1016/j.jmr.2004.05.015

Liquid-State NMR and Scalar Couplings in Microtesla Magnetic Fields
journal, March 2002

McDermott, R.
Science, Vol. 295, Issue 5563
https://doi.org/10.1126/science.1069280

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
journal, August 2003

Xiong, Jinhu; Fox, Peter T.; Gao, Jia-Hong
Human Brain Mapping, Vol. 20, Issue 1, p. 41-49
https://doi.org/10.1002/hbm.10124

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Similar Records

Title: Hypothesis-driven classification of materials using nuclear magnetic resonance relaxometry

Abstract

Citation Formats

Zeugmatography process patent, June 1983

Method and apparatus for measuring the distribution of elements contained in sample patent, January 1997

Apparatus and method for generating short pulses for NMR and NQR processing patent, September 1998

Temperature compensated magnetic field apparatus for NMR measurements patent, June 2003

Method and apparatus for high resolution ex-situ NMR spectroscopy patent, January 2004

Method of multivariate spectral analysis patent, January 2004

Nuclear resonance based scanning system having an automatic object identification and attribute information acquisition and linking mechanism integrated therein patent, June 2006

Remote NMR/MRI detection of laser polarized gases patent, June 2006

NMR and MRI apparatus and method patent, March 2007

Method and apparatus for detecting contraband using radiated compound signatures patent, July 2007

Mine detector with NQR-SQUID patent, July 2008

Method for determining the content of at least one component of a sample by means of a nuclear magnetic resonance pulse spectrometer patent, July 2008

Method for molecule examination by NMR spectroscopy patent, June 2009

Direct imaging of neural currents using ultra-low field magnetic resonance techniques patent, August 2009

Ultra-low field nuclear magnetic resonance and magnetic resonance imaging to discriminate and identify materials patent, March 2010

Noise cancellation in magnetoencephalography and electroencephalography with isolated reference sensors patent, June 2010

Method, a processor, and a system for identifying a substance patent, July 2010

Toward direct mapping of neuronal activity: MRI detection of ultraweak, transient magnetic field changes journal, June 2002

SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields journal, June 2005

SQUID detected NMR in microtesla magnetic fields journal, September 2004

Liquid-State NMR and Scalar Couplings in Microtesla Magnetic Fields journal, March 2002

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging journal, August 2003

Zeugmatography process
patent, June 1983

Method and apparatus for measuring the distribution of elements contained in sample
patent, January 1997

Apparatus and method for generating short pulses for NMR and NQR processing
patent, September 1998

Temperature compensated magnetic field apparatus for NMR measurements
patent, June 2003

Method and apparatus for high resolution ex-situ NMR spectroscopy
patent, January 2004

Method of multivariate spectral analysis
patent, January 2004

Nuclear resonance based scanning system having an automatic object identification and attribute information acquisition and linking mechanism integrated therein
patent, June 2006

Remote NMR/MRI detection of laser polarized gases
patent, June 2006

NMR and MRI apparatus and method
patent, March 2007

Method and apparatus for detecting contraband using radiated compound signatures
patent, July 2007

Mine detector with NQR-SQUID
patent, July 2008

Method for determining the content of at least one component of a sample by means of a nuclear magnetic resonance pulse spectrometer
patent, July 2008

Method for molecule examination by NMR spectroscopy
patent, June 2009

Direct imaging of neural currents using ultra-low field magnetic resonance techniques
patent, August 2009

Ultra-low field nuclear magnetic resonance and magnetic resonance imaging to discriminate and identify materials
patent, March 2010

Noise cancellation in magnetoencephalography and electroencephalography with isolated reference sensors
patent, June 2010

Method, a processor, and a system for identifying a substance
patent, July 2010

Toward direct mapping of neuronal activity: MRI detection of ultraweak, transient magnetic field changes
journal, June 2002

SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields
journal, June 2005

SQUID detected NMR in microtesla magnetic fields
journal, September 2004

Liquid-State NMR and Scalar Couplings in Microtesla Magnetic Fields
journal, March 2002

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
journal, August 2003