Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same
Abstract
Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula ##STR00001## where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Southern California, Los Angeles, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1281082
- Patent Number(s):
- 9403875
- Application Number:
- 12/695,125
- Assignee:
- University of Southern California (Los Angeles, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Jan 27
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Conti, Peter S., Cai, Hancheng, Li, Zibo, and Liu, Shuanglong. Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same. United States: N. p., 2016.
Web.
Conti, Peter S., Cai, Hancheng, Li, Zibo, & Liu, Shuanglong. Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same. United States.
Conti, Peter S., Cai, Hancheng, Li, Zibo, and Liu, Shuanglong. Tue .
"Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same". United States. https://www.osti.gov/servlets/purl/1281082.
@article{osti_1281082,
title = {Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same},
author = {Conti, Peter S. and Cai, Hancheng and Li, Zibo and Liu, Shuanglong},
abstractNote = {Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula ##STR00001## where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Metal radionuclide labeled proteins for diagnosis and therapy
patent, September 1993
- Fritzberg, Alan R.; Kasina, Sudhakar; Srinivasan, Ananthachari
- US Patent Document 5,242,679
MicroPET and Autoradiographic Imaging of Breast Cancer α v -Integrin Expression Using 18 F- and 64 Cu-Labeled RGD Peptide
journal, January 2004
- Chen, Xiaoyuan; Park, Ryan; Tohme, Michel
- Bioconjugate Chemistry, Vol. 15, Issue 1
Method for labeling antibodies with a metal ion
patent, October 1991
- Pak, Koon Y.; Dean, Richard T.; Mattis, Jeffrey A.
- US Patent Document 5,053,493
Metal radionuclide labeled proteins for diagnosis and therapy
patent, December 1992
- Fritzberg, Alan R.; Kasina, Sudhakar; Srinivasan, Ananthachari
- US Patent Document 5,175,343
Radiolabeled Multimeric Cyclic RGD Peptides as Integrin α v β 3 Targeted Radiotracers for Tumor Imaging
journal, July 2006
- Liu, Shuang
- Molecular Pharmaceutics, Vol. 3, Issue 5
Synthesis, Copper(II) Complexation, 64 Cu-Labeling, and Bioconjugation of a New Bis(2-pyridylmethyl) Derivative of 1,4,7-Triazacyclononane
journal, March 2008
- Gasser, Gilles; Tjioe, Linda; Graham, Bim
- Bioconjugate Chemistry, Vol. 19, Issue 3
PET (positron emission tomography) imaging of biomolecules using metal–DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics
journal, January 2008
- Tanaka, Katsunori; Fukase, Koichi
- Organic & Biomolecular Chemistry, Vol. 6, Issue 5