Ketol-acid reductoisomerase enzymes and methods of use
- Inventors:
- Issue Date:
- Research Org.:
- Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1261630
- Patent Number(s):
- 9388392
- Application Number:
- 14/853,108
- Assignee:
- Butamax Advanced Biofuels LLC (Wilmington, DE)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AR0000006
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Sep 14
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 09 BIOMASS FUELS
Citation Formats
Govindarajan, Sridhar, Li, Yougen, Liao, Der-Ing, O'Keefe, Daniel P., Minshull, Jeremy Stephen, Rothman, Steven Cary, and Tobias, Alexander Vincent. Ketol-acid reductoisomerase enzymes and methods of use. United States: N. p., 2016.
Web.
Govindarajan, Sridhar, Li, Yougen, Liao, Der-Ing, O'Keefe, Daniel P., Minshull, Jeremy Stephen, Rothman, Steven Cary, & Tobias, Alexander Vincent. Ketol-acid reductoisomerase enzymes and methods of use. United States.
Govindarajan, Sridhar, Li, Yougen, Liao, Der-Ing, O'Keefe, Daniel P., Minshull, Jeremy Stephen, Rothman, Steven Cary, and Tobias, Alexander Vincent. Tue .
"Ketol-acid reductoisomerase enzymes and methods of use". United States. https://www.osti.gov/servlets/purl/1261630.
@article{osti_1261630,
title = {Ketol-acid reductoisomerase enzymes and methods of use},
author = {Govindarajan, Sridhar and Li, Yougen and Liao, Der-Ing and O'Keefe, Daniel P. and Minshull, Jeremy Stephen and Rothman, Steven Cary and Tobias, Alexander Vincent},
abstractNote = {},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}
Works referenced in this record:
Carbon and electron flow in Clostridium butyricum grown in chemostat culture on glycerol and on glucose
journal, May 1996
- Abbad-Andaloussi, S.; Durr, C.; Raval, G.
- Microbiology, Vol. 142, Issue 5
Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors.
journal, September 1994
- Arthur, M.; Depardieu, F.; Snaith, H. A.
- Antimicrobial Agents and Chemotherapy, Vol. 38, Issue 9
The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65Aresolution
journal, June 1997
- Biou, V.
- The EMBO Journal, Vol. 16, Issue 12
Targeted Disruption of the kstD Gene Encoding a 3-Ketosteroid Delta 1-Dehydrogenase Isoenzyme of Rhodococcus erythropolis Strain SQ1
journal, May 2000
- van der Geize, R.; Hessels, G. I.; van Gerwen, R.
- Applied and Environmental Microbiology, Vol. 66, Issue 5
Mechanism of ketol acid reductoisomerase. Steady-state analysis and metal ion requirement
journal, January 1989
- Chunduru, Srinivas K.; Mrachko, Gregory T.; Calvo, K. C.
- Biochemistry, Vol. 28, Issue 2
Mycobacterium sp.,Rhodococcus erythropolis, andPseudomonas putida behavior in the presence of organic solvents
journal, January 2004
- De Carvalho, Carla C. C. R.; Da Cruz, Alexandra A. R. L.; Pons, Marie-N�elle
- Microscopy Research and Technique, Vol. 64, Issue 3
Biochemical and molecular characterization of α-ketoisovalerate decarboxylase, an enzyme involved in the formation of aldehydes from amino acids by Lactococcus lactis
journal, September 2004
- Plaza, Marta; Fernández de Palencia, Pilar; Peláez, Carmen
- FEMS Microbiology Letters, Vol. 238, Issue 2
Ethanol production from cellulose by coupled saccharification/fermentation usingSaccharomyces cerevisiae and cellulase complex fromSclerotiun rolfsii UV-8 mutant
journal, September 1992
- Deshpande, Mukund V.
- Applied Biochemistry and Biotechnology, Vol. 36, Issue 3, p. 227-234
Solventogenic enzymes of Clostridium acetobutylicum: catalytic properties, genetic organization, and transcriptional regulation
journal, October 1995
- Dürre, Peter; Fischer, Ralf-Jörg; Kuhn, Anita
- FEMS Microbiology Reviews, Vol. 17, Issue 3, p. 251-262
Characterization of Ypr1p fromSaccharomyces cerevisiae as a 2-methylbutyraldehyde reductase
journal, January 2002
- Ford, Gordon; Ellis, Elizabeth M.
- Yeast, Vol. 19, Issue 12
pAM401-Based Shuttle Vectors That Enable Overexpression of Promoterless Genes and One-Step Purification of Tag Fusion Proteins Directly from Enterococcus faecalis
journal, March 2001
- Fujimoto, S.; Ike, Y.
- Applied and Environmental Microbiology, Vol. 67, Issue 3, p. 1262-1267
Technologies for butanol recovery integrated with fermentations
journal, March 1992
- Groot, W. J.; van der Lans, R. G. J. M.; Luyben, K. Ch. A. M.
- Process Biochemistry, Vol. 27, Issue 2, p. 61-75
SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling
journal, January 1997
- Guex, Nicolas; Peitsch, Manuel C.
- Electrophoresis, Vol. 18, Issue 15, p. 2714-2723
Improved methods for building protein models in electron density maps and the location of errors in these models
journal, March 1991
- Jones, T. A.; Zou, J. Y.; Cowan, S. W.
- Acta Crystallographica Section A Foundations of Crystallography, Vol. 47, Issue 2, p. 110-119
Effect of aliphatic alcohols on growth and degree of saturation of membrane lipids in Acinetobacter calcoaceticus
journal, March 2003
- Kabelitz, Nadja; Santos, Pedro M.; Heipieper, Hermann J.
- FEMS Microbiology Letters, Vol. 220, Issue 2, p. 223-227
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
journal, May 2000
- Datsenko, K. A.; Wanner, B. L.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 12, p. 6640-6645
A small cryptic plasmid from Rhodococcus erythropolis: characterization and utility for gene expression
journal, July 2003
- Kostichka, K.; Tao, L.; Bramucci, M.
- Applied Microbiology and Biotechnology, Vol. 62, Issue 1
Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene product as a broad specificity NADPH-dependent alcohol dehydrogenase: relevance in aldehyde reduction
journal, January 2002
- Larroy, Carol; Fernandez, M. Rosario; Gonzalez, Eva
- Biochemical Journal, Vol. 361, Issue 1, p. 163-172
Modular expression and secretion vectors for Bacillus subtilis
journal, May 1992
- Nagarajan, Vasantha; Albertson, Helene; Chen, Mario
- Gene, Vol. 114, Issue 1, p. 121-126
Construction of Improved Temperature-Sensitive and Mobilizable Vectors and Their Use for Constructing Mutations in the Adhesin-Encoding acm Gene of Poorly Transformable Clinical Enterococcus faecium Strains
journal, January 2006
- Nallapareddy, S. R.; Singh, K. V.; Murray, B. E.
- Applied and Environmental Microbiology, Vol. 72, Issue 1
High- and low-copy-number Lactococcus shuttle cloning vectors with features for clone screening
journal, December 1993
- O'Sullivan, Daniel J.; Klaenhammer, Todd R.
- Gene, Vol. 137, Issue 2, p. 227-231
Plasmid vectors for Gram-positive bacteria switching from high to low copy number
journal, January 1996
- Renault, Pierre; Corthier, Gerard; Goupil, Nathalie
- Gene, Vol. 183, Issue 1-2, p. 175-182
Sequences of versatile broad-host-range vectors of the RK2 family
journal, July 2003
- Scott, Heather N.; Laible, Philip D.; Hanson, Deborah K.
- Plasmid, Vol. 50, Issue 1, p. 74-79
Identification, Cloning, and Characterization of a Lactococcus lactis Branched-Chain  -Keto Acid Decarboxylase Involved in Flavor Formation
journal, January 2005
- Smit, B. A.; van Hylckama Vlieg, J. E. T.; Engels, W. J. M.
- Applied and Environmental Microbiology, Vol. 71, Issue 1
Proliferation and metabolic significance of peroxisomes in Candida boidinii during growth on d-alanine or oleic acid as the sole carbon source
journal, April 1990
- Sulter, G. J.; Waterham, H. R.; Goodman, J. M.
- Archives of Microbiology, Vol. 153, Issue 5
Crystal Structure of E.coli Alcohol Dehydrogenase YqhD: Evidence of a Covalently Modified NADP Coenzyme
journal, September 2004
- Sulzenbacher, Gerlind; Alvarez, Karine; van den Heuvel, Robert H. H.
- Journal of Molecular Biology, Vol. 342, Issue 2, p. 489-502
Analysis of the Conjugal Transfer System of the Pheromone- Independent Highly Transferable Enterococcus Plasmid pMG1: Identification of a tra Gene (traA) Up-Regulated during Conjugation
journal, October 2002
- Tanimoto, K.; Ike, Y.
- Journal of Bacteriology, Vol. 184, Issue 20, p. 5800-5804
Construction of highly efficient E. coli expression systems containing low oxygen induced promoter and partition region
journal, February 2005
- Liu, Tao; Chen, Jing-yu; Zheng, Zhong
- Applied Microbiology and Biotechnology, Vol. 68, Issue 3
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
journal, January 1994
- Thompson, Julie D.; Higgins, Desmond G.; Gibson, Toby J.
- Nucleic Acids Research, Vol. 22, Issue 22, p. 4673-4680
Transcriptional Analysis of Butanol Stress and Tolerance in Clostridium acetobutylicum
journal, March 2004
- Tomas, C. A.; Beamish, J.; Papoutsakis, E. T.
- Journal of Bacteriology, Vol. 186, Issue 7
The crystal structure of a bacterial Class II ketol-acid reductoisomerase: Domain conservation and evolution
journal, December 2005
- Tyagi, Rajiv; Duquerroy, Stephane; Navaza, Jorge
- Protein Science, Vol. 14, Issue 12
Functional Analysis of Three Plasmids from Lactobacillus plantarum
journal, March 2005
- van Kranenburg, R.; Golic, N.; Bongers, R.
- Applied and Environmental Microbiology, Vol. 71, Issue 3, p. 1223-1230
Purification and characterization of a fusion protein of plant acetohydroxy acid synthase and acetohydroxy acid isomeroreductase
journal, May 1997
- Dumas, Renaud; Biou, Valérie; Douce, Roland
- FEBS Letters, Vol. 408, Issue 2, p. 156-160
Mevalonate and Nonmevalonate Pathways for the Biosynthesis of Isoprene Units
journal, January 2002
- Kuzuyama, Tomohisa
- Bioscience, Biotechnology, and Biochemistry, Vol. 66, Issue 8
Fusel Alcohols Production in Beer Fermentation Processes
journal, January 1994
- GarcÃa, Ana I.; GarcÃa, Luis A.; DÃaz, Mario
- Process Biochemistry, Vol. 29, Issue 4, p. 303-309
Guerbet condensation of methanol with n-propanol to isobutyl alcohol over heterogeneous bifunctional catalysts based on Mg–Al mixed oxides partially substituted by different metal components
journal, May 2005
- Carlini, Carlo; Marchionna, Mario; Noviello, Marilena
- Journal of Molecular Catalysis A: Chemical, Vol. 232, Issue 1-2, p. 13-20
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension
journal, April 1989
- Horton, Robert M.; Hunt, Henry D.; Ho, Steffan N.
- Gene, Vol. 77, Issue 1, p. 61-68
Complete Genomic Sequence of the Filamentous Nitrogen-fixing Cyanobacterium Anabaena sp. Strain PCC 7120
journal, January 2001
- Kaneko, T.
- DNA Research, Vol. 8, Issue 5
An Investigation of the Metabolism of Valine to Isobutyl Alcohol in Saccharomyces cerevisiae
journal, October 1998
- Dickinson, J. Richard; Harrison, Scott J.; Hewlins, Michael J. E.
- Journal of Biological Chemistry, Vol. 273, Issue 40, p. 25751-25756
Formation of ethanol and higher alcohols by immobilized zymomonas mobilis in continuous culture
journal, January 1991
- Oaxaca, V. A.; Jones, L. P.
- Acta Biotechnologica, Vol. 11, Issue 6
Switch of coenzyme specificity of p -hydroxybenzoate hydroxylase 1 1Edited by A. R. Fersht
journal, September 1999
- Eppink, Michel H. M.; Overkamp, Karin M.; Schreuder, Herman A.
- Journal of Molecular Biology, Vol. 292, Issue 1
Identifying determinants of NADPH specificity in Baeyer-Villiger monooxygenases: NADPH specificity in BVMOs
journal, May 2004
- Kamerbeek, Nanne M.; Fraaije, Marco W.; Janssen, Dick B.
- European Journal of Biochemistry, Vol. 271, Issue 11
Towards a new interaction enzyme:coenzyme
journal, April 2005
- MartÃnez-Júlvez, Marta; Tejero, Jesús; R. Peregrina, José
- Biophysical Chemistry, Vol. 115, Issue 2-3, p. 219-224
Reversal of the Nucleotide Specificity of Ketol Acid Reductoisomerase by Site-Directed Mutagenesis Identifies the NADPH Binding Site1
journal, February 1997
- Rane, Madhavi J.; Calvo, K. C.
- Archives of Biochemistry and Biophysics, Vol. 338, Issue 1
Crystal Structure of Class I Acetohydroxy Acid Isomeroreductase from Pseudomonas aeruginosa
journal, April 2003
- Ahn, Hyung Jun; Eom, Su Jung; Yoon, Hye-Jin
- Journal of Molecular Biology, Vol. 328, Issue 2, p. 505-515
Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
journal, June 2005
- Paulsen, Ian T.; Press, Caroline M.; Ravel, Jacques
- Nature Biotechnology, Vol. 23, Issue 7
Enzymology, Structure, and Dynamics of Acetohydroxy Acid Isomeroreductase
journal, May 2001
- Dumas, Renaud; Biou, Valérie; Halgand, Frédéric
- Accounts of Chemical Research, Vol. 34, Issue 5
Modification of the Nucleotide Cofactor-binding Site of Cytochrome P-450 Reductase to Enhance Turnover with NADH in Vivo
journal, October 2002
- Elmore, C. Lee; Porter, Todd D.
- Journal of Biological Chemistry, Vol. 277, Issue 50
The X-ray structure of Brassica napus β-keto acyl carrier protein reductase and its implications for substrate binding and catalysis
journal, April 2000
- Fisher, Martin; Kroon, Johan T. M.; Martindale, Wayne
- Structure, Vol. 8, Issue 4, p. 339-347
Computational design of Candida boidinii xylose reductase for altered cofactor specificity
journal, October 2009
- Khoury, George A.; Fazelinia, Hossein; Chin, Jonathan W.
- Protein Science, Vol. 18, Issue 10
Characterization of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase, an Enzyme Involved in Isopentenyl Diphosphate Biosynthesis, and Identification of Its Catalytic Amino Acid Residues
journal, April 2000
- Kuzuyama, Tomohisa; Takahashi, Shunji; Takagi, Motoki
- Journal of Biological Chemistry, Vol. 275, Issue 26
Probing the Determinants of Coenzyme Specificity in Ferredoxin-NADP + Reductase by Site-directed Mutagenesis
journal, January 2001
- Medina, Milagros; Luquita, Alejandra; Tejero, Jesús
- Journal of Biological Chemistry, Vol. 276, Issue 15
Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprint
journal, January 1986
- Wierenga, Rik K.; Terpstra, Peter; Hol, Wim G. J.
- Journal of Molecular Biology, Vol. 187, Issue 1, p. 101-107
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
journal, June 2013
- Brinkmann-Chen, S.; Flock, T.; Cahn, J. K. B.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 27, p. 10946-10951
Nucleotide sequence and characterization of a cDNA encoding the acetohydroxy acid isomeroreductase from Arabidopsis thaliana
journal, February 1993
- Curien, Gilles; Dumas, Renaud; Douce, Roland
- Plant Molecular Biology, Vol. 21, Issue 4
Purification and characterization of acetohydroxyacid reductoisomerase from spinach chloroplasts
journal, September 1989
- Dumas, R.; Joyard, J.; Douce, R.
- Biochemical Journal, Vol. 262, Issue 3
A single amino acid substitution in lactate dehydrogenase improves the catalytic efficiency with an alternative coenzyme
journal, January 1990
- Feeney, Raymond; Clarke, Anthony R.; Holbrook, J. John
- Biochemical and Biophysical Research Communications, Vol. 166, Issue 2, p. 667-672
Process for extractive fermentation
patent, September 1989
- Kollerup, Finn; Daugulis, Andrew J.
- US Patent Document 4,865,973
Nucleic acid coding for an .alpha.-acetolactate synthase from lactococcus and its applications
patent, July 1997
- Ehrlich, Stanislav; Godon, Jean-Jacques; Renault, Pierre
- US Patent Document 5,643,779
Method for the production of &rgr;-Hydroxybenzoate in species of pseudomonas and agrobacterium
patent, July 2003
- Ben-Bassat, Arie; Cattermole, Monica; Gatenby, Anthony A.
- US Patent Document 6,586,229
Solvent tolerant microorganisms and methods of isolation
patent, June 2009
- Bramucci, Michael G.; Nagarajan, Vasantha; Sedkova, Natalia
- US Patent Document 7,541,173
Fermentive production of four carbon alcohols
patent, December 2010
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 7,851,188
Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
patent, March 2011
- Liao, Der-Ing; Nelson, Mark J.; Bramucci, Michael G.
- US Patent Document 7,910,342
Fermentive production of four carbon alcohols
patent, August 2011
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 7,993,889
Solvent tolerant microorganisms
patent, September 2011
- Bramucci, Michael G.; Kane, Helene M. A.; Nagarajan, Vasantha
- US Patent Document 8,017,364
Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
patent, December 2011
- Dundon, Catherine Asleson; Aristidou, Aristos; Hawkins, Andrew
- US Patent Document 8,071,358
Ketol-acid reductoisomerase using NADH
patent, March 2012
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,129,162
Fermentive production of four carbon alcohols
patent, May 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,178,328
Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
patent, May 2012
- Bramucci, Michael G.; Eliot, Andrew C.; Maggio-Hall, Lori Ann
- US Patent Document 8,188,250
Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
patent, June 2012
- Eliot, Andrew C.; Nagarajan, Vasantha; Huang, Lixuan Lisa
- US Patent Document 8,206,970
Ketol-acid reductoisomerase using NADH
patent, July 2012
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,222,017
Recombinant yeast host cell with Fe-S cluster proteins and methods of using thereof
patent, August 2012
- Anthony, Larry Cameron; Flint, Dennis; Suh, Wonchul
- US Patent Document 8,241,878
Fermentive production of four carbon alcohols
patent, September 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,273,558
Fermentive production of four carbon alcohols
patent, October 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,283,144
Production of four carbon alcohols using improved strain
patent, February 2013
- Larossa, Robert A.; Smulski, Dana R.; Nagarajan, Vasantha
- US Patent Document 8,372,612
Yeast strain for production of four carbon alcohols
patent, March 2013
- Larossa, Robert A.
- US Patent Document 8,389,252
Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
patent, June 2013
- Paul, Brian James
- US Patent Document 8,455,224
Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
patent, June 2013
- Bramucci, Michael G.; Larossa, Robert A.; Smulski, Dana R.
- US Patent Document 8,455,225
Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
patent, June 2013
- Anthony, Larry Cameron
- US Patent Document 8,465,964
Strain comprising increased expression of a CFA coding region for butanol production
patent, August 2013
- Flint, Dennis; Larossa, Robert A.; Nagarajan, Vasantha
- US Patent Document 8,518,678
Yeast with increased butanol tolerance involving filamentous growth response
patent, October 2013
- Bramucci, Michael G.; Larossa, Robert A.; Singh, Manjari
- US Patent Document 8,557,562
Yeast with increased butanol tolerance involving a multidrug efflux pump gene
patent, December 2013
- Van Dyk, Tina K.
- US Patent Document 8,614,085
Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
patent, January 2014
- Paul, Brian James; Suh, Wonchul
- US Patent Document 8,637,281
Expression of hexose kinase in recombinant host cells
patent, January 2014
- Anthony, Larry Cameron; Kruckeberg, Arthur Leo
- US Patent Document 8,637,289
Strain for butanol production with increased membrane unsaturated trans fatty acids
patent, February 2014
- Flint, Dennis; Van Dyk, Tina K.
- US Patent Document 8,652,823
Enhanced pyruvate to acetolactate conversion in yeast
patent, March 2014
- Anthony, Larry Cameron; Maggio-Hall, Lori Ann
- US Patent Document 8,669,094
Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
patent, April 2014
- Bramucci, Michael G.; Eliot, Andrew C.; Maggio-Hall, Lori Ann
- US Patent Document 8,691,540
Fermentive production of four carbon alcohols
patent, May 2014
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,735,114
Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols
patent, July 2014
- Satagopan, Sriram; O'Keefe, Daniel P.; Gude, Janardhan
- US Patent Document 8,765,433
Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
patent, July 2014
- Anthony, Larry Cameron
- US Patent Document 8,785,166
Yeast with increased butanol tolerance involving cell wall integrity pathway
patent, August 2014
- Bramucci, Michael G.; Larossa, Robert A.; Smulski, Dana R.
- US Patent Document 8,795,992
Production of isobutanol in yeast mitochondria
patent, September 2014
- Anthony, Larry Cameron; Huang, Lixuan Lisa; Ye, Rick W.
- US Patent Document 8,828,694
Fermentive production of four carbon alcohols
patent, September 2014
- Donaldson, Gail K.; Eliot, Andrew C.; Maggio-Hall, Lori Ann
- US Patent Document 8,828,704
Recombinant host cells comprising phosphoketolases
patent, October 2014
- Dauner, Michael; Maggio-Hall, Lori Ann; Tomb, Jean-Francois
- US Patent Document 8,871,488
Fermentive production of four carbon alcohols
patent, November 2014
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,889,385
Ketol-acid reductoisomerase using NADH
patent, November 2014
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,895,307
Engineering resistance to aliphatic alcohols
patent, December 2014
- Alsaker, Keith; Grenfell-Lee, Daniel; Hudson, Michael
- US Patent Document 8,906,666
Ketol-acid reductoisomerase using NADH
patent, December 2014
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,911,981
Yeast strain for production of four carbon alcohols
patent, January 2015
- Larossa, Robert A.
- US Patent Document 8,940,511
Production of isobutanol by a microorganism with enhanced acetolactate synthase activity
patent, February 2015
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,945,859
Ketol-acid reductoisomerase using NADH
patent, February 2015
- Li, Yougen; Liao, Der-Ing; Nelson, Mark J.
- US Patent Document 8,945,899
Fermentive production of four carbon alcohols
patent, February 2015
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Document 8,951,774
Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases
patent, February 2015
- Flint, Dennis; Rothman, Steven Cary; Suh, Wonchul
- US Patent Document 8,951,937
Enhanced pyruvate to acetolactate conversion in yeast
patent, February 2015
- Anthony, Larry Cameron; Maggio-Hall, Lori Ann
- US Patent Document 8,956,850
Recombinant host cell comprising a diol dehydratase
patent, February 2015
- Donaldson, Gail K.; Eliot, Andrew C.; Nagarajan, Vasantha
- US Patent Document 8,962,298
Enhanced pyruvate to acetolactate conversion in yeast
patent, March 2015
- Anthony, Larry Cameron; Maggio-Hall, Lori Ann
- US Patent Document 8,969,065
Fermentive production of four carbon alcohols
patent, March 2015
- Donaldson, Gail K.; Eliot, Andrew C.; Nagarajan, Vasantha
- US Patent Document 8,980,612
Method for producing ethanol using raw starch
patent-application, November 2004
- Lewis, Stephen M.; Van Hulzen, Shon Erron; Finck, John Michael
- US Patent Application 10/798226; 20040234649
Treatment of biomass to obtain fermentable sugars
patent-application, February 2007
- Dunson, Jr., James B.; Elander, Richard T.; Tucker, III, Melvin P.
- US Patent Application 11/402757; 20070031918
Fermentative Production Of Four Carbon Alcohols
patent-application, April 2007
- Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis
- US Patent Application 11/586315; 20070092957
Fermentive Production Of Four Carbon Alcohols
patent-application, July 2008
- Donaldson, Gail K.; Huang, Lixuan Lisa; Maggio-Hall, Lori Ann
- US Patent Application 11/527995; 20080182308
Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
patent-application, October 2008
- Liao, Der-Ing; Nelson, Mark J.; Bramucci, Michael G.
- US Patent Application 12/103844; 20080261230
Identification and use of Bacterial [2FE-2S] Dihydroxy-acid Dehydratases
patent-application, April 2010
- Flint, Dennis; Rothman, Steven Cary; Suh, Wonchul
- US Patent Application 12/569636; 20100081154
Enhanced Iron-sulfur Cluster Formation for Increased Dihydroxy-Acid Dehydratase Activity in Lactic Acid Bacteria
patent-application, April 2010
- Paul, Brain James; Suh, Wonchul
- US Patent Application 12/569103; 20100081182
Carbon Pathway Optimized Production Hosts for the Production of Isobutanol
patent-application, May 2010
- Anthony, Larry Cameron; Dauner, Michael; Donaldson, Gail K.
- US Patent Application 12/606410; 20100120105
Cytosolic Isobutanol Pathway Localization for the Production of Isobutanol
patent-application, March 2011
- Urano, Jun; Dundon, Catherine Asleson; Meinhold, Peter
- US Patent Application 12/855276; 20110076733
Bacterial Strains for Butanol Production
patent-application, August 2011
- Euler, Lori Jean; Flint, Dennis; Paul, Brian James
- US Patent Application 12/899760; 20110195505
Fermentive Production of Isobutanol Using Highly Effective Ketol-acid Reductoisomerase Enzymes
patent-application, October 2011
- Nagarajan, Vasantha; Paul, Brian James; Suh, Wonchul
- US Patent Application 12/893077; 20110244536
Engineering Resistance to Aliphatic Alcohols
patent-application, March 2012
- Alsaker, Keith; Grenfell-Lee, Daniel; Hudson, Michael
- US Patent Application 13/214310; 20120058541
Fermentive Production of Four Carbon Alcohols
patent-application, August 2012
- Donaldson, Gail K.; Eliot, Andrew C.; Nagarajan, Vasantha
- US Patent Application 13/281872; 20120196341
Lignocellulosic Hydrolysates as Feedstocks for Isobutanol Fermentation
patent-application, February 2013
- Dobson, Ian David; Kruckeberg, Arthur Leo
- US Patent Application 13/525032; 20130035515
Acetate Supplementation of Medium for Butanologens
patent-application, September 2013
- Maggio-Hall, Lori Ann
- US Patent Application 13/833369; 20130252296
Host Cells and Methods for Production of Isobutanol
patent-application, January 2014
- Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa
- US Patent Application 13/840649; 20140030782
Host Cells and Methods for Production of Isobutanol
patent-application, January 2014
- Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa
- US Patent Application 13/840676; 20140030783
Activity of FE-S Cluster Requiring Proteins
patent-application, February 2014
- Flint, Dennis; Paul, Brian James; Ye, Rick W.
- US Patent Application 13/837921; 20140038263
Dhad Variants for Butanol Production
patent-application, July 2014
- Maggio-Hall, Loriann Ann; Paul, Brian James; Rothman, Steven Cary
- US Patent Application 14/142,398; 2014/0186910 Al