Methods for producing 3-hydroxypropionic acid and other products
Abstract
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.
- Inventors:
- Issue Date:
- Research Org.:
- The Regents of the University of Colorado, a Body Corporate, Denver, CO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1261625
- Patent Number(s):
- 9388419
- Application Number:
- 13/916,534
- Assignee:
- The Regents of the University of Colorado, a Body Corporate (Denver, CO)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- DOE Contract Number:
- AR0000088
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 Jun 12
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 09 BIOMASS FUELS
Citation Formats
Lynch, Michael D., Gill, Ryan T., and Lipscomb, Tanya E. W. Methods for producing 3-hydroxypropionic acid and other products. United States: N. p., 2016.
Web.
Lynch, Michael D., Gill, Ryan T., & Lipscomb, Tanya E. W. Methods for producing 3-hydroxypropionic acid and other products. United States.
Lynch, Michael D., Gill, Ryan T., and Lipscomb, Tanya E. W. Tue .
"Methods for producing 3-hydroxypropionic acid and other products". United States. https://www.osti.gov/servlets/purl/1261625.
@article{osti_1261625,
title = {Methods for producing 3-hydroxypropionic acid and other products},
author = {Lynch, Michael D. and Gill, Ryan T. and Lipscomb, Tanya E. W.},
abstractNote = {This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}
Works referenced in this record:
Malonyl-Coenzyme A Reductase in the Modified 3-Hydroxypropionate Cycle for Autotrophic Carbon Fixation in Archaeal Metallosphaera and Sulfolobus spp.
journal, October 2006
- Alber, B.; Olinger, M.; Rieder, A.
- Journal of Bacteriology, Vol. 188, Issue 24, p. 8551-8559
Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase
journal, January 1988
- Anton, I. A.; Coggins, J. R.
- Biochemical Journal, Vol. 249, Issue 2
A New Enzymatic Method of Acrylamide Production
journal, May 1982
- Asano, Yasuhisa; Yasuda, Takamune; Tani, Yoshiki
- Agricultural and Biological Chemistry, Vol. 46, Issue 5
Inverse metabolic engineering: A strategy for directed genetic engineering of useful phenotypes
journal, July 2002
- Bailey, James E.; Sburlati, Adriana; Hatzimanikatis, Vassily
- Biotechnology and Bioengineering, Vol. 79, Issue 5
Induction of specific base-pair substitutions in E. coli trpA mutants by chloroenthylene oxide, a carcinogenic vinyl chloride metabolite
journal, November 1985
- Barbin, Alain; Besson, Francoise; Perrard, Marie-Hélène
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 152, Issue 2-3, p. 147-156
Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli
journal, May 2011
- Bastian, Sabine; Liu, Xiang; Meyerowitz, Joseph T.
- Metabolic Engineering, Vol. 13, Issue 3, p. 345-352
The biological degradation of cellulose
journal, January 1994
- Beguin, Pierre; Aubert, Jean-Paul
- FEMS Microbiology Reviews, Vol. 13, Issue 1, p. 25-58
Sequences of the envM gene and of two mutated alleles in Escherichia coli
journal, October 1992
- Bergler, H.; Hogenauer, G.; Turnowsky, F.
- Journal of General Microbiology, Vol. 138, Issue 10
Naturally Occurring Adenines within mRNA Coding Sequences Affect Ribosome Binding and Expression in Escherichia coli
journal, November 2006
- Brock, J. E.; Paz, R. L.; Cottle, P.
- Journal of Bacteriology, Vol. 189, Issue 2
Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids
journal, November 1998
- Broun, Pierre; Shanklin, John; Whittle, Ed
- Science, Vol. 282, Issue 5392, p. 1315-1317
Synthesis of labeled acrylamide andN-methylolacrylamide (NMA):15N-acrylamide,13C-NMA,15N-NMA, and13C,15N-NMA
journal, January 2005
- Brown, N. R.; Frazier, C. E.
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 48, Issue 14
The IdhA Gene Encoding the Fermentative Lactate Dehydrogenase of Escherichia Coli
journal, January 1997
- Bunch, P. K.; Mat-Jan, F.; Lee, N.
- Microbiology, Vol. 143, Issue 1
Directed Evolution of Toluene ortho-Monooxygenase for Enhanced 1-Naphthol Synthesis and Chlorinated Ethene Degradation
journal, January 2002
- Canada, K. A.; Iwashita, S.; Shim, H.
- Journal of Bacteriology, Vol. 184, Issue 2
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design
journal, August 2005
- Chica, Roberto A.; Doucet, Nicolas; Pelletier, Joelle N.
- Current Opinion in Biotechnology, Vol. 16, Issue 4, p. 378-384
Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using coupled transaminase reactions
journal, January 2003
- Cho, Byung-Kwan; Cho, Ho Jung; Park, Sung-Hee
- Biotechnology and Bioengineering, Vol. 81, Issue 7
The commercial production of chemicals using pathway engineering
journal, December 2000
- Chotani, Gopal; Dodge, Tim; Hsu, Amy
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1543, Issue 2
Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria
journal, January 2007
- Cleusix, Valentine; Lacroix, Christophe; Vollenweider, Sabine
- BMC Microbiology, Vol. 7, Issue 1
DNA shuffling of a family of genes from diverse species accelerates directed evolution
journal, January 1998
- Crameri, Andreas; Raillard, Sun-Ai; Bermudez, Ericka
- Nature, Vol. 391, Issue 6664
Cloning, crystallization and preliminary characterization of a β-carbonic anhydrase from Escherichia coli
journal, September 2000
- Cronk, Jeff D.; O'Neill, Jason W.; Cronk, Michelle R.
- Acta Crystallographica Section D Biological Crystallography, Vol. 56, Issue 9, p. 1176-1179
Thermal regulation of membrane lipid fluidity in bacteria
journal, February 1983
- de Mendoza, Diego; Cronan, John E.
- Trends in Biochemical Sciences, Vol. 8, Issue 2, p. 49-52
Practical limits of function prediction
journal, January 2000
- Devos, Damien; Valencia, Alfonso
- Proteins: Structure, Function, and Genetics, Vol. 41, Issue 1, p. 98-107
The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids
book, January 2009
- Dewick, Paul M.
- Medicinal Natural Products: A Biosynthetic Approach, 3rd Edition
Engineering of a functional human NADH-dependent cytochrome P450 system
journal, January 2001
- Dohr, O.; Paine, M. J. I.; Friedberg, T.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 1
Structure of the EntB Multidomain Nonribosomal Peptide Synthetase and Functional Analysis of Its Interaction with the EntE Adenylation Domain
journal, April 2006
- Drake, Eric J.; Nicolai, David A.; Gulick, Andrew M.
- Chemistry & Biology, Vol. 13, Issue 4, p. 409-419
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
journal, October 2004
- Duncan, S. H.; Louis, P.; Flint, H. J.
- Applied and Environmental Microbiology, Vol. 70, Issue 10
The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase
journal, September 1986
- Duncan, K.; Chaudhuri, S.; Campbell, M. S.
- Biochemical Journal, Vol. 238, Issue 2
Switch of coenzyme specificity of p -hydroxybenzoate hydroxylase 1 1Edited by A. R. Fersht
journal, September 1999
- Eppink, Michel H. M.; Overkamp, Karin M.; Schreuder, Herman A.
- Journal of Molecular Biology, Vol. 292, Issue 1
Improving lycopene production in Escherichia coli by engineering metabolic control
journal, May 2000
- Farmer, William R.; Liao, James C.
- Nature Biotechnology, Vol. 18, Issue 5
Biorefineries:  Current Status, Challenges, and Future Direction
journal, July 2006
- Fernando, Sandun; Adhikari, Sushil; Chandrapal, Chauda
- Energy & Fuels, Vol. 20, Issue 4, p. 1727-1737
Methionine Biosynthesis in Escherichia coli and Corynebacterium glutamicum
book, January 2006
- Figge, Rainer M.
- Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering
A Novel Quinone-forming Monooxygenase Family Involved in Modification of Aromatic Polyketides
journal, February 2005
- Funa, Nobutaka; Funabashi, Masanori; Yoshimura, Etsuro
- Journal of Biological Chemistry, Vol. 280, Issue 15
Genome-wide screening for trait conferring genes using DNA microarrays
journal, May 2002
- Gill, R. T.; Wildt, S.; Yang, Y. T.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 10, p. 7033-7038
Identification and cloning of the Mycobacterium avium folA gene, required for dihydrofolate reductase activity
journal, November 1997
- Zywno-van Ginkel, Sabrina; Dooley, Thomas P.; Suling, William J.
- FEMS Microbiology Letters, Vol. 156, Issue 1, p. 69-78
Metabolic Analysis of Escherichia coli in the Presence and Absence of the Carboxylating Enzymes Phosphoenolpyruvate Carboxylase and Pyruvate Carboxylase
journal, May 2000
- Gokarn, R. R.; Eiteman, M. A.; Altman, E.
- Applied and Environmental Microbiology, Vol. 66, Issue 5
Monofunctional chorismate mutase from Bacillus subtilis: purification of the protein, molecular cloning of the gene, and overexpression of the gene product in Escherichia coli
journal, January 1990
- Gray, Joseph V.; Golinelli-Pimpaneau, Beatrice; Knowles, Jeremy R.
- Biochemistry, Vol. 29, Issue 2
Overproduction of phage Lambda repressor under control of the lac promotor of Escherichia coli
journal, January 1976
- Gronenborn, Bruno
- MGG Molecular & General Genetics, Vol. 148, Issue 3
Genetic Evidence for an Interaction of the UbiG O-Methyltransferase with UbiX in Escherichia coli Coenzyme Q Biosynthesis
journal, August 2006
- Gulmezian, M.; Zhang, H.; Javor, G. T.
- Journal of Bacteriology, Vol. 188, Issue 17
A T42M Substitution in Bacterial 5-Enolpyruvylshikimate-3-phosphate Synthase (EPSPS) Generates Enzymes with Increased Resistance to Glyphosate
journal, January 2003
- He, Ming; Nie, Yan-Fang; Xu, Peilin
- Bioscience, Biotechnology, and Biochemistry, Vol. 67, Issue 6
Enoyl-Acyl Carrier Protein Reductase ( fabI ) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli
journal, November 1995
- Heath, Richard J.; Rock, Charles O.
- Journal of Biological Chemistry, Vol. 270, Issue 44
Oxidation of Cysteine 645 of Cobalamin-Independent Methionine Synthase Causes a Methionine Limitation in Escherichia coli
journal, March 2009
- Hondorp, E. R.; Matthews, R. G.
- Journal of Bacteriology, Vol. 191, Issue 10
Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation
journal, May 2002
- Hugler, M.; Menendez, C.; Schagger, H.
- Journal of Bacteriology, Vol. 184, Issue 9, p. 2404-2410
Biosynthetic pathways for 3-hydroxypropionic acid production
journal, February 2009
- Jiang, Xinglin; Meng, Xin; Xian, Mo
- Applied Microbiology and Biotechnology, Vol. 82, Issue 6
Purification and characterization of 2-oxoglutarate decarboxylase of Leuconostoc oenos
journal, August 1990
- Kapol, R.; Radler, F.
- Journal of General Microbiology, Vol. 136, Issue 8
Engineering primary metabolic pathways of industrial micro-organisms
journal, March 2007
- Kern, Alexander; Tilley, Emma; Hunter, Iain S.
- Journal of Biotechnology, Vol. 129, Issue 1, p. 6-29
Extractive recovery of products from fermentation broths
journal, April 1999
- Kim, Joong Kyun; Iannotti, Eugene L.; Bajpai, Rakesh
- Biotechnology and Bioprocess Engineering, Vol. 4, Issue 1
The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems
journal, April 2010
- Kim, K. -S.; Pelton, J. G.; Inwood, W. B.
- Journal of Bacteriology, Vol. 192, Issue 16
Dihydrolipoamide Dehydrogenase Mutation Alters the NADH Sensitivity of Pyruvate Dehydrogenase Complex of Escherichia coli K-12
journal, March 2008
- Kim, Y.; Ingram, L. O.; Shanmugam, K. T.
- Journal of Bacteriology, Vol. 190, Issue 11, p. 3851-3858
Effect of Overexpression of Actinobacillus succinogenes Phosphoenolpyruvate Carboxykinase on Succinate Production in Escherichia coli
journal, February 2004
- Kim, P.; Laivenieks, M.; Vieille, C.
- Applied and Environmental Microbiology, Vol. 70, Issue 2
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
journal, January 2007
- Kimchi-Sarfaty, C.; Oh, J. M.; Kim, I.-W.
- Science, Vol. 315, Issue 5811, p. 525-528
Polypeptide Release Factors in Prokaryotes and Eukaryotes
journal, January 2002
- Kisselev, Lev
- Structure, Vol. 10, Issue 1, p. 8-9
Reactions of β-lactones with potassium alkoxides and their complexes with 18-crown-6 in aprotic solvents
journal, July 1993
- Kurcok, Piotr; Jedlinski, Zbigniew; Kowalczuk, Marek
- The Journal of Organic Chemistry, Vol. 58, Issue 16
A Physiology Study of Escherichia coli Overexpressing Phosphoenolpyruvate Carboxykinase
journal, April 2008
- Kwon, Yeong-Deok; Lee, Sang Yup; Kim, Pil
- Bioscience, Biotechnology, and Biochemistry, Vol. 72, Issue 4
A new preparation of trifluoromethanesulfinate salts
journal, July 2007
- Langlois, Bernard R.; Billard, Thierry; Mulatier, Jean-Christophe
- Journal of Fluorine Chemistry, Vol. 128, Issue 7, p. 851-856
A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes
journal, June 2010
- Lennen, Rebecca M.; Braden, Drew J.; West, Ryan M.
- Biotechnology and Bioengineering, Vol. 106, Issue 2, p. 193-202
Effect of poxB gene knockout on metabolism in Escherichia coli based on growth characteristics and enzyme activities
journal, September 2006
- Li, Mai; Yao, Shanjing; Shimizu, Kazuyuki
- World Journal of Microbiology and Biotechnology, Vol. 23, Issue 4
Feedback Inhibition of Chorismate Mutase/Prephenate Dehydrogenase (TyrA) of Escherichia coli: Generation and Characterization of Tyrosine-Insensitive Mutants
journal, November 2005
- Lutke-Eversloh, T.; Stephanopoulos, G.
- Applied and Environmental Microbiology, Vol. 71, Issue 11
SCALEs: multiscale analysis of library enrichment
journal, November 2006
- Lynch, Michael D.; Warnecke, Tanya; Gill, Ryan T.
- Nature Methods, Vol. 4, Issue 1
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
journal, June 2003
- Martin, Vincent J. J.; Pitera, Douglas J.; Withers, Sydnor T.
- Nature Biotechnology, Vol. 21, Issue 7
Aminotransferases: demonstration of homology and division into evolutionary subgroups
journal, June 1993
- Mehta, Perdeep K.; Hale, Terence I.; Christen, Philipp
- European Journal of Biochemistry, Vol. 214, Issue 2
Effect of process parameters on 3-hydroxypropionic acid production from glycerol using a recombinant Escherichia coli
journal, April 2009
- Mohan Raj, Subramanian; Rathnasingh, Chelladurai; Jung, Woo-Chel
- Applied Microbiology and Biotechnology, Vol. 84, Issue 4
Diversion of the Metabolic Flux from Pyruvate Dehydrogenase to Pyruvate Oxidase Decreases Oxidative Stress during Glucose Metabolism in Nongrowing Escherichia coli Cells Incubated under Aerobic, Phosphate Starvation Conditions
journal, October 2004
- Moreau, P. L.
- Journal of Bacteriology, Vol. 186, Issue 21
The Lysine Decarboxylase CadA Protects Escherichia coli Starved of Phosphate against Fermentation Acids
journal, January 2007
- Moreau, P. L.
- Journal of Bacteriology, Vol. 189, Issue 6
Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
journal, December 2006
- Nackley, A. G.; Shabalina, S. A.; Tchivileva, I. E.
- Science, Vol. 314, Issue 5807, p. 1930-1933
Cloning and Overexpression in Soluble Form of Functional Shikimate Kinase and 5-Enolpyruvylshikimate 3-Phosphate Synthase Enzymes from Mycobacterium tuberculosis
journal, August 2001
- Oliveira, Jaim S.; Pinto, Clotilde A.; Basso, Luiz A.
- Protein Expression and Purification, Vol. 22, Issue 3
A novel methodology employing Corynebacterium glutamicum genome information to generate a new L -lysine-producing mutant
journal, January 2002
- Ohnishi, S. Mitsuhashi, M. Hayashi,, J.
- Applied Microbiology and Biotechnology, Vol. 58, Issue 2
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway
journal, June 2010
- Okamura, E.; Tomita, T.; Sawa, R.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 25, p. 11265-11270
Metabolic engineering of aromatic group amino acid pathway in Bacillus subtilis for L-phenylalanine production
journal, November 2004
- Özçelik, İlknur Şenver; Çalık, Pinar; Çalık, Güzide
- Chemical Engineering Science, Vol. 59, Issue 22-23, p. 5019-5026
Directed evolution of RuBisCO hypermorphs through genetic selection in engineered E.coli
journal, January 2006
- Parikh, Monal R.; Greene, Dina N.; Woods, Kristen K.
- Protein Engineering, Design and Selection, Vol. 19, Issue 3, p. 113-119
Genome shuffling of Lactobacillus for improved acid tolerance
journal, July 2002
- Patnaik, Ranjan; Louie, Susan; Gavrilovic, Vesna
- Nature Biotechnology, Vol. 20, Issue 7
A new perspective on thiamine catalysis
journal, August 2004
- Pohl, M.
- Current Opinion in Biotechnology, Vol. 15, Issue 4
Polyphosphate Kinase Protects Salmonella enterica from Weak Organic Acid Stress
journal, April 2005
- Price-Carter, M.; Fazzio, T. G.; Vallbona, E. I.
- Journal of Bacteriology, Vol. 187, Issue 9
Effect of process parameters on 3-hydroxypropionic acid production from glycerol using a recombinant Escherichia coli
journal, April 2009
- Mohan Raj, Subramanian; Rathnasingh, Chelladurai; Jung, Woo-Chel
- Applied Microbiology and Biotechnology, Vol. 84, Issue 4
A mild and efficient method for esterification and transesterification catalyzed by iodine
journal, January 2002
- Ramalinga, K.; Vijayalakshmi, P.; Kaimal, T. N. B.
- Tetrahedron Letters, Vol. 43, Issue 5, p. 879-882
Preparation of Esters of Acrylic Acid
patent, March 1949
- Redmon, Bryan C.; Griffin, George R.
- US Patent Document 2464768
Polyacrylic acid having high chelation value and its production
patent, September 1975
- Shahidi, Iraj Khatib; Blay, Jorge
- US Patent Document 3,904,685
Unsaturated carboxylic acid-long chain alkyl ester copolymers and tri-polymers water thickening agents and emulsifiers
patent, October 1975
- Schlatzer, Robert
- US Patent Document 3,915,921
Polymers for use in water treatment
patent, June 1977
- Godlewski, Irene T.; Schuck, Joseph J.; Libutti, Bruce L.
- US Patent Document 4,029,577
Acrylic acid-acrylate copolymer thickening agents
patent, May 1981
- Koenig, Harvey S.; Bryant, George M.
- US Patent Document 4,268,641
Manufacture of polymers of acrylic acid or methacrylic acid
patent, November 1981
- Muenster, Alfred; Rohmann, Michael
- US Patent Document 4,301,266
Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca.sub.3 (PO.sub.4).sub.2
patent, February 1984
- Dubin, Leonard
- US Patent Document 4,431,547
Absorbent article
patent, May 1987
- Tsubakimoto, Tsuneo; Shimomura, Tadao; Irie, Yoshio
- US Patent Document 4,666,983
Disposable diaper having density and basis weight profiled absorbent core
patent, August 1987
- Hasse, Margaret Henderson; Steinhardt, Mark John
- US Patent Document 4,685,915
Suspending agent for the suspension polymerization of water-soluble monomers
patent, November 1987
- Stanley, Jr., Frederick W.; Lamphere, Jack C.; Chonde, Yohannes
- US Patent Document 4,708,997
Water absorbing agent
patent, March 1988
- Tsubakimoto, Tsuneo; Shimomura, Tadao; Irie, Yoshio
- US Patent Document 4,734,478
Process for the continuous production of polymers and copolymers of water-soluble monomers
patent, August 1989
- Chmelir, Miroslav; Pauen, Josef
- US Patent Document 4,857,610
Fermentation of trichoderma reesei and apparatus therefor
patent, August 1990
- Cho, Michael
- US Patent Document 4,952,505
Process for preparing water-absorbing resins
patent, January 1991
- Alexander, William; Anderson, Mark C.; Regan, Barbara R.
- US Patent Document 4,985,518
Thin, flexible sanitary napkin
patent, April 1991
- Osborn, III, Thomas Ward
- US Patent Document 5,009,653
Removal of residual solvent from acrylic acid polymer
patent, March 1992
- Bresciani, Angelo
- US Patent Document 5,093,472
Process for producing acid-type maleic acid polymer and water-treating agent and detergent additive containing said polymer
patent, August 1992
- Yamaguchi, Shigeru; Shioji, Shorbu; Irie, Yoshio
- US Patent Document 5,135,677
Super-absorbent polymer having improved absorbency properties
patent, September 1992
- Chambers, Douglas R.; Fowler, Jr., Hubert H.; Fujiura, Yoji
- US Patent Document 5,145,906
Process for production of water-absorbent resin
patent, January 1993
- Nakamura, Morio; Yamamoto, Takushi; Tanaka, Hitoshi
- US Patent Document 5,180,798
Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
patent, October 1993
- Gewain, Keith M.; MacNeil, Douglas J.; MacNeil, Tanya
- US Patent Document 5,252,474
Hydrophilic, highly swellable hydrogels
patent, July 1994
- Engelhardt, Friedrich; Funk, Rüdiger; Riegel, Ulrich
- US Patent Document 5,331,059
Process for recycling aqueous fluid absorbents fines to a polymerizer
patent, August 1994
- Graham, Andrew T.; Gartner, Herbert
- US Patent Document 5,342,899
Process for the conversion of fine superabsorbent polymer particles into larger particles
patent, September 1994
- Woodrum, Guy Thomas; Majette, Thomas H.
- US Patent Document 5,350,799
Free radical copper(II)-enolate polymerization initiators
patent, November 1995
- Harwood, H. James; Goodrich, Stephen D.
- US Patent Document 5,470,928
Free radical initiator delivery system
patent, April 1996
- Narayanan, Kolazi S.; De Thomas, Waldo
- US Patent Document 5,510,307
Lactic acid production, separation and/or recovery process
patent, April 1996
- Baniel, Abraham M.; Eyal, Aharon; Mizrahi, Joseph
- US Patent Document 5,510,526
Sanitary napkin having an internal shaping component
patent, September 1996
- Bergman, Carl L.
- US Patent Document 5,558,656
Esterification of fermentation-derived acids via pervaporation
patent, March 1998
- Datta, Rathin; Tsai, Shih-Perng
- US Patent Document 5,723,639
Process for the production of malonic acid or a salt thereof
patent, October 1998
- Haas, Thomas; Meier, Martin; Brossmer, Christoph
- US Patent Document 5,817,870
Sanitary napkin comprising an absorbent core having a density gradient
patent, October 1998
- Crainic, Sorin
- US Patent Document 5,827,255
Mutant phosphoenolpyruvate carboxylase, its gene, and production method of amino acid
patent, March 1999
- Sugimoto, Masakazu; Suzuki, Tomoko; Matsui, Hiroshi
- US Patent Document 5,876,983
Method for producing L-lysine
patent, December 1999
- Araki, Masayuki; Sugimoto, Masakazu; Yoshihara, Yasuhiko
- US Patent Document 6,004,773
Method for the production of 1,3-propanediol by recombinant microorganisms
patent, January 2000
- Nakamura, Charles E.; Gatenby, Anthony A.; Hsu, Amy Kuang-Hua
- US Patent Document 6,013,494
Microbial production of 1,2-propanediol from sugar
patent, July 2000
- Cameron, Douglas C.; Shaw, Anita J.; Altaras, Nedim E.
- US Patent Document 6,087,140
Method for producing nucleic acid substances
patent, September 2001
- Sato, Katsuaki; Usuda, Yoshihiro
- US Patent Document 6,284,495
Water-absorbing agent and production process therefor
patent, October 2001
- Nagasuna, Kinya; Fujino, Shinichi; Nakamura, Masatoshi
- US Patent Document 6,297,319
Method for producing hydroxycarboxylic acids by auto-degradation of polyhydroxyalkanoates
patent, October 2002
- Lee, Sang Yup; Wang, Fulai; Lee, Young Jin
- US Patent Document 6,472,188
Lactic acid processing; methods; arrangements; and, products
patent, March 2003
- Eyal, Aharon; Starr, John N.; Fisher, Rod R.
- US Patent Document 6,534,679
Process for preparation of D-pantothenic acid and/or salts thereof
patent, September 2003
- Rieping, Mechthild
- US Patent Document 6,623,944
Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin
patent, March 2004
- Tu, Kuo-Chi
- US Patent Document 6,709,919
Acid-dyeable polymer compositions
patent, April 2004
- Sun, Yanhui; Higley, David P.
- US Patent Document 6,723,799
Production of 3-hydroxypropionic acid in recombinant organisms
patent, February 2005
- Suthers, Patrick F.; Cameron, Douglas C.
- US Patent Document 6,852,517
Methods of making amino acids using E. coli transformed with csc genes
patent, November 2005
- Livshits, Vitaliy Arkadyevich; Doroshenko, Vera Georgievna; Mashko, Sergei
- US Patent Document 6,960,455
System to connect conduit sections in a subterranean well
patent, August 2006
- Read, Barry
- US Patent Document 7,090,008
Single-stage separation and esterification of cation salt carboxylates using electrodeionization
patent, November 2006
- Lin, YuPo J.; Henry, Michael P.; Hestekin, Jamie A.
- US Patent Document 7,141,154
Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
patent, December 2006
- Payne, Mark S.; DiCosimo, Robert; Gavagan, John Edward
- US Patent Document 7,153,663
Methods of making intermediates from polyhydroxyalkanoates
patent, January 2007
- Zhong, Luhua; Whitehouse, Robert S.
- US Patent Document 7,166,743
3-hydroxypropionic acid and other organic compounds
patent, March 2007
- Gokarn, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Document 7,186,541
Process for preparing carboxylic acids and derivatives thereof
patent, March 2007
- Meng, Xiangsheng; Tsobanakis, Paraskevas; Malsam, Jeffrey J.
- US Patent Document 7,186,856
Mutant E. coli strain with increased succinic acid production
patent, May 2007
- Ka-Yiu, San; Bennett, George N.; Sanchez, Ailen
- US Patent Document 7,223,567
Process for separating and recovering 3-hydroxypropionic acid and acrylic acid
patent, October 2007
- Meng, Xiangsheng; Tsobanakis, Paraskevas; Malsam, Jeffrey J.
- US Patent Document 7,279,598
Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
patent, October 2007
- Payne, Mark S.; DiCosimo, Robert; Gavagan, John Edward
- US Patent Document 7,285,406
Alanine 2,3-Aminomutase
patent, December 2007
- Liao, Hans H.; Gokarn, Ravi R.; Gort, Steven John
- US Patent Document 7,309,597
Increasing intracellular NADPH availability in E. coli
patent, February 2008
- San, Ka-Yiu; Bennett, George N.; Sanchez, Ailen
- US Patent Document 7,326,557
Production of 3-hydroxycarboxylic acid using nitrilase mutants
patent, April 2008
- Payne, Mark S.; DiCosimo, Robert; O'Keefe, Daniel P.
- US Patent Document 7,358,071
3-Hydroxypropionic acid and other organic compounds
patent, July 2008
- Gokarn, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Document 7,393,676
Utilization of fructose in microbial production strains
patent, April 2009
- Caimi, Perry G.; Nakamura, Charles E.
- US Patent Document 7,524,660
Preparation of acrylic acid derivatives from α- or β-hydroxy carboxylic acids
patent, May 2009
- Craciun, Liliana; Benn, Gerald P.; Dewing, John
- US Patent Document 7,538,247
3-hydroxypropionic acid and other organic compounds
patent, December 2009
- Gokarn, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Document 7,638,316
Atom or group transfer radical polymerization
patent, March 2010
- Matyjaszewski, Krzysztof; Gaynor, Scott G.; Coca, Simion
- US Patent Document 7,678,869
Method for conversion of β-hydroxy carbonyl compounds
patent, March 2010
- Lilga, Michael A.; White, James F.; Holladay, Johnathan E.
- US Patent Document 7,687,661
Method for redesign of microbial production systems
patent, November 2010
- Maranas, Costas D.; Burgard, Anthony P.; Pharkya, Priti
- US Patent Document 7,826,975
Amino acid producing microorganism and a method for producing an amino acid
patent, November 2010
- Terashita, Masaru; Usuda, Yoshihiro; Matsui, Kazuhiko
- US Patent Document 7,833,761
Biosynthesis of phloroglucinol and preparation of 1,3-dihydroxybenzene therefrom
patent, May 2011
- Frost, John W.
- US Patent Document 7,943,362
Compositions and methods for 3-hydroxypropionate bio-production from biomass
patent, November 2011
- Lynch, Michael D.
- US Patent Document 8,048,624
Method for producing an organic acid
patent, December 2011
- Fukui, Keita; Tajima, Yoshinori; Kawamura, Kazue
- US Patent Document 8,076,111
Compositions and methods for 3-hydroxypropionate bio-production from biomass
patent, February 2014
- Lynch, Michael D.
- US Patent Document 8,652,816
Production of Polyhydroxyalkanoates From Polyols
patent-application, November 2002
- Skraly, Frank A.; Sholl, Martha
- US Patent Application 09/909574; 20020164729
Schizochytrium PKS Genes
patent-application, May 2003
- Facciotti, Daniel; Metz, James George; Lassner, Michael
- US Patent Application 10/331061; 20030101486
Novel Antimicrobial Activity of Gemfibrozil and Related Compounds and Derivatives and Metabolites Thereof
patent-application, October 2003
- Kabbash, Christina; Silverstein, Samuel C.; Shuman, Howard A.
- US Patent Application 10/366686; 20030191146
Expression of microbial proteins in plants for production of plants with improved properties
patent-application, December 2003
- Cao, Yongwei; Hinkle, Gregory J.; Slater, Steven C.
- US Patent Application 10/369493; 20030233675
Production Of Polyketides
patent-application, December 2003
- Katz, Leonard; Revill, Peter
- US Patent Application 10/607809; 20030235892
Method For Determining Gene Knockouts
patent-application, January 2004
- Maranas, Costas D.; Burgard, Anthony P.; Pharkya, Priti
- US Patent Application 10/616659; 20040009466 A1
3-hydroxypropionic Acid And Other Organic Compounds
patent-application, April 2004
- Gokarm, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Application 10/432443; 20040076982 A1
Materials and methods for the efficient production of acetate and other products
patent-application, August 2004
- Causey, Thomas B.; Ingram, Lonnie O'Neal; Zhou, Shengde
- US Patent Application 10/703812; 20040152159
Process for the Biological Production of 1,3-propanediol With High Yield
patent-application, August 2004
- Cervin, Marguerite A.; Soucaille, Philippe; Valle, Fernando
- US Patent Application 10/680286; 20040152174
Synthesis of 1,2,3,4-tetrahydroxybenzenes From Biomass-derived Carbon
patent-application, October 2004
- Frost, John W.; Hansen, Chad A.
- US Patent Application 10/838551; 20040209337
Process for Preparing Carboxylic Acids and Derivatives Thereof
patent-application, October 2004
- Meng, Xiangsheng; Tsobanakis, Paraskevas; Malsam, Jeffrey
- US Patent Application 10/476711; 20040210087
Process for the production of L-amino acids using strains of the enterobacteriaceae family
patent-application, October 2004
- Rieping, Mechthild
- US Patent Application 10/812315; 20040214294
Method for the Preparation of an Evolved Microorganism for the Creation or the Modification of Metabolic Pathways
patent-application, March 2005
- Chateau, Michel; Gonzalez, Benjamin; Meynial-Salles, Isabelle
- US Patent Application 10/781499; 20050054060
Novel Enoyl Reductases and Methods of Use Thereof
patent-application, September 2005
- Rock, Charles O.; Heath, Richard John
- US Patent Application 10/616550; 20050196758
Alanine 2,3,aminomutase
patent-application, October 2005
- Liao, Hans H.; Gokarn, Ravi R.; Gort, Steven J.
- US Patent Application 10/502040; 20050221466
Preparation of acrylic acid derivatives from alpha-or beta-hydroxy carboxylic acids
patent-application, October 2005
- Craciun, Liliana; Benn, Gerald P.; Dewing, John
- US Patent Application 11/093485; 20050222458
Production Of Fermentation Product
patent-application, October 2005
- Hughes, Jonathan
- US Patent Application 10/523302; 20050233031
Polyhydroxyalkanoate Production From Polyols
patent-application, October 2005
- Skraly, Frank A.; Peoples, Oliver P.
- US Patent Application 11/072735; 20050239179
Process for Preparation of 1,3-propanediol
patent-application, December 2005
- Meng, Xiangsheng; Abraham, Timothy W.; Tsobanakis, Paraskevas
- US Patent Application 10/532938; 20050283029
Process for Production of Organic Acid Esters
patent-application, January 2006
- Miller, Dennis J.; Asthana, Navinchandra; Kolah, Aspi
- US Patent Application 10/894307; 20060014977
Mixed-library Parallel Gene Mapping Quantitative Micro-array Technique For Genome-wide Identification Of Trait Conferring Genes
patent-application, April 2006
- Gill, Ryan T.; Lynch, Michael D.; Warnecke, Tanya
- US Patent Application 11/231018; 20060084098
Instruments And Methods For Accessing An Anatomic Space
patent-application, January 2007
- Ness, Gregory O.
- US Patent Application 11/520238; 20070010708
Optimised Micro-organism Strains For Nadph-consuming Biosynthetic Pathways
patent-application, April 2007
- Bestel-Vorre, Gwenaelle; Boisart, Cedric; Chateau, Michel
- US Patent Application 10/577084; 20070087403 A1
Production of 3-hydropropionic Acid Using Beta-alanine/pyruvate Aminotransferase
patent-application, May 2007
- Liao, Hans H.; Gokarn, Ravi R.; Gort, Steven John
- US Patent Application 10/581570; 20070107080
Process For Producing 1,3-propanediol and/or 3-hydroxypropionic Acid
patent-application, June 2007
- Yasuda, Shinzo; Mukoyama, Masaharu; Horikawa, Hiroshi
- US Patent Application 10/594417; 20070148749
3-hydroxypropionic acid and other organic compounds
patent-application, August 2007
- Gokarn, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Application 11/539856; 20070184524
Method and Apparatus for Conversion of Beta-hydroxy Carbonyl Compounds
patent-application, September 2007
- Zacher, Alan H.; Holladay, Johnathan E.; Lilga, Michael A.
- US Patent Application 11/377052; 20070219390
Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems
patent-application, October 2007
- Metz, James G.; Kuner, Jerry M.; Lippmeier, James Casey
- US Patent Application 11/686850; 20070245431
3-Hydroxypropionic Acid And Other Organic Compounds
patent-application, March 2008
- Gokarn, Ravi R.; Selfifonova, Olga V.; Jessen, Holly Jean
- US Patent Application 11/942669; 20080076167
Alanine 2, 3-aminomutase
patent-application, May 2008
- Liao, Hans H.; Gokarn, Ravi R.; Gort, Steven J.
- US Patent Application 11/938154; 20080124785
Energy Efficient Methods To Produce Products
patent-application, August 2008
- Verser, Dan W.; Eggeman, Timothy J.
- US Patent Application 12/029321; 20080193989
Methods and Organisms for Growth-Coupled Production of 3-Hydroxypropionic Acid
patent-application, August 2008
- Burgard, Anthony P.; Van Dien, Stephen J.
- 12/018129; 20080199926
Membrane Supported Bioreactor For Conversion Of Syngas Components To Liquid Products
patent-application, January 2009
- Datta, Rathin; Tsai, Shih-Perng; Basu, Rahul
- US Patent Application 12/205540; 20090017514
Water-absorbent polymer structures based on renewable resources and method for producing said structures
patent-application, January 2009
- Bub, Gunther; Mosler, Jurgen; Sabbagh, Andreas
- US Patent Application 11/817204; 20090023006
Alanine 2, 3 Aminomutases
patent-application, January 2009
- Jessen, Holly Jean; Gokarn, Ravi R.; Gort, Steven John
- US Patent Application 11/658795; 20090031453
3-hydroxypropionic acid and other organic compounds
patent-application, February 2009
- Gokarn, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Application 12/127700; 20090053783
Process for Converting a Hydroxycarboxylic Acid, or Salts Thereof, to an Unsaturated Carboxylic Acid and/or Its Esters
patent-application, March 2009
- Bogan, Jr., Leonard Edward; Silvano, Mark Anthony; Zolotorofe, Donald L.
- US Patent Application 12/283050; 20090076297
Method for the Production of Resveratrol in a Recombinant Oleaginous Microorganism
patent-application, March 2009
- Huang, Lixuan Lisa; Xue, Zhixiong; Zhu, Quinn Qun
- US Patent Application 11/436182; 20090082286
Production of Polyketides
patent-application, April 2009
- Julien, Bryan; Katz, Leonard; Khosla, Chaitan
- US Patent Application 11/933002; 20090111151
Strain for butanol production
patent-application, August 2009
- Flint, Dennis; Larossa, Robert A.; Nagarajan, Vasantha
- US Patent Application 12/330534; 20090203097
Methods and Composition for Extraction and Transesterification of Biomass Components
patent-application, September 2009
- Cooney, Michael J.; Young, Gregory
- US Patent Application 12/404176; 20090234146
Beta-alanine/alpha-ketoglutarate Aminotransferase for 3-hydroxypropionic Acid Production
patent-application, November 2009
- Jessen, Holly Jean; Liao, Hans H.; Gort, Steven John
- US Patent Application 12/310503; 20090291480
Methods of manufacturing derivatives of beta-hydroxycarboxylic acids
patent-application, December 2009
- Tsobanakis, Paraskevas; Meng, Xiangsheng; Abraham, Timothy W.
- US Patent Application 12/507008; 20090298144
Deletion mutants for the production of isobutanol
patent-application, December 2009
- Donaldson, Gail K.; Maggio-Hall, Lori Ann; Nakamura, Charles E.
- US Patent Application 12/477946; 20090305369
Microbiological Production Of 3-Hydroxypropionic Acid
patent-application, December 2009
- Marx, Achim; Wendisch, Volker F.; Rittmann, Doris
- US Patent Application 12/067266; 20090325248 A1
Biological Synthesis Of Difunctional Alkanes From Carbohydrate Feedstocks
patent-application, June 2010
- Baynes, Brian M.; Geremia, John Michael
- US Patent Application 12/637340; 20100151536
Compositions and Methods for Enhancing Tolerance for the Production of Organic Chemicals Produced by Microorganisms
patent-application, August 2010
- Gill, Ryan T.; Lipscomb, Tanya E.; Lynch, Michael D.
- US Patent Application 12/523047; 20100210017
Production of an Organic Acid and/or Related Chemicals
patent-application, May 2011
- Lynch, Michael D.
- US Patent Application 12/952149; 20110125118
Process for the Biological Production of 3-Hydroxypropionic Acid with High Yield
patent-application, June 2011
- Eliot, Andrew C.; Van Dyk, Tina K.
- US Patent Application 12/815461; 20110144377
Biosynthesis Of Phloroglucinol And Preparation Of 1,3-Dihydroxybenzene Therefrom
patent-application, July 2011
- Frost, John W.
- US Patent Application 13/081993; 20110183391
Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP)
patent-application, October 2011
- Lipscomb, Tanya E. W.; Lynch, Michael D.; Gill, Ryan T.
- US Patent Application 13/055138; 20110244575
Carboxylic acid recovery and methods related thereto
patent-application, November 2011
- Orjuela, Alvaro; Yanez-Mckav, Abraham; Lira, Carl
- US Patent Application 13/145731; 20110275851
Compositions and methods for 3-hydroxypropionate bio-production from biomass
patent-application, February 2012
- Lynch, Michael D.
- US Patent Application 13/284337; 20120041232
3-Hydroxypropionic Acid and Other Organic Compounds
patent-application, September 2012
- Gokarn, Ravi R.; Selifonova, Olga V.; Jessen, Holly Jean
- US Patent Application 13/467165; 20120244586 A1
Methods, Systems And Compositions For Increased Microorganism Tolerance To And Production Of 3-Hydroxypropionic Acid (3-HP)
patent-application, October 2012
- Lipscomb, Tanya E. W.; Lynch, Michael D.; Gill, Ryan T.
- US Patent Application 13/416103; 20120264902
Methods for producing 3-hydroxypropionic acid and other products
patent-application, March 2013
- Lynch, Michael D.; Gill, Ryan T.; Lipscomb, Tanya E. W.
- US Patent Application 13/498468; 20130071893
Microorganism Production of High-Value Chemical Products, and Related Compositions, Methods and Systems
patent-application, May 2013
- Lynch, Michael D.; Gil, Ryan T.; Lipscomb, Tanya E. W.
- US Patent Application 13/575581; 20130122541 A1
Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxyproplonic Acid (3-HP) To Aldehyde Metabolites
patent-application, July 2013
- Lynch, Michael D.; Mercogliano, Christopher P.; Lipscomb, Matthew L.
- US Patent Application 13/062917; 20130189787
Purification Of 3-Hydroxypropionic Acid From Crude Cell Broth And Production Of Acrylamide
patent-application, December 2013
- Tengler, Robert; DeCoster, David
- US Patent Application 13/527799; 20130345470
Compositions and methods for 3-hydroxypropionate bio-production from biomass
patent-application, May 2014
- Lynch, Michael D.
- US Patent Application 14/067838; 20140135526