Title: Methods for producing 3-hydroxypropionic acid and other products

Abstract

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.

Inventors:

Lynch, Michael D.; Gill, Ryan T.; Lipscomb, Tanya E. W.

Issue Date:

2016-07-12

Research Org.:

The Regents of the University of Colorado, a Body Corporate, Denver, CO (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1261625

Patent Number(s):

9388419

Application Number:

13/916,534

Assignee:

The Regents of the University of Colorado, a Body Corporate (Denver, CO)

Patent Classifications (CPCs):

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

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C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

C08L33/08 - Homopolymers or copolymers of acrylic acid esters

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Y02P20/52 - using catalysts, e.g. selective catalysts

C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY

C12M47/12 - {Purification

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P7/42 - Hydroxy-carboxylic acids

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/16 - acting on ester bonds

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

A61L15/24 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y102/04001 - Pyruvate dehydrogenase
C12Y301/02 - Thioester hydrolases
C12Y207/00 - Transferases transferring phosphorus-containing groups

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P7/40 - containing a carboxyl group {including Peroxycarboxylic acids

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/12 - transferring phosphorus containing groups, e.g. kinases
C12N9/0008 - {acting on the aldehyde or oxo group of donors
C12N15/63 - Introduction of foreign genetic material using vectors

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P11/00 - Preparation of sulfur-containing organic compounds
C12P7/52 - Propionic acid
C12P7/62 - Carboxylic acid esters {

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DOE Contract Number:  

AR0000088

Resource Type:

Patent

Resource Relation:

Patent File Date: 2013 Jun 12

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 09 BIOMASS FUELS