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Title: Apparatus comprising magnetically actuated valves and uses thereof

Abstract

The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Inventors:
;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1261607
Patent Number(s):
9389231
Application Number:
14/157,335
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Jan 16
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Edwards, Thayne L., and Harper, Jason C.. Apparatus comprising magnetically actuated valves and uses thereof. United States: N. p., 2016. Web.
Edwards, Thayne L., & Harper, Jason C.. Apparatus comprising magnetically actuated valves and uses thereof. United States.
Edwards, Thayne L., and Harper, Jason C.. Tue . "Apparatus comprising magnetically actuated valves and uses thereof". United States. https://www.osti.gov/servlets/purl/1261607.
@article{osti_1261607,
title = {Apparatus comprising magnetically actuated valves and uses thereof},
author = {Edwards, Thayne L. and Harper, Jason C.},
abstractNote = {The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}

Works referenced in this record:

Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008


Point-of-care nucleic acid testing for infectious diseases
journal, May 2011


Stabilization of Peracid Solutions
patent, April 1944


Stabilization of Dilute Solutions of Aliphatic Acids
patent, April 1952


Stabilization of Peracids with Dipicolinic Acid
patent, September 1952


Stable peroxy-containing microbicides
patent, September 1977


Stable, shippable, peroxy-containing microbicide
patent, August 1997


Fluorogenic compounds
patent, April 2002


Fluorogenic compounds and uses therefor
patent, May 2003


Microwell cell-culture device and fabrication method
patent, September 2012


Methods for the detection, analysis and isolation of nascent proteins
patent, October 2012


Methods and apparatus for pathogen detection and analysis
patent-application, April 2006


Arrays, Substrates, Devices, Methods And Systems For Detecting Target Molecules
patent-application, February 2009


Microfluidic Devices, Methods And Systems For Detecting Target Molecules
patent-application, February 2009


On-chip cell migration detection
patent-application, October 2009


Dilute Aqueous Peracid Solutions and Stabilization Method
patent-application, January 2010


Thin Film Valve Device And Its Controlling Apparatus
patent-application, September 2010


Thin Film Bio Valve Device And Its Controlling Apparatus
patent-application, November 2010


Microfluidic Platform For Cell Culture And Assay
patent-application, June 2011


Methods For The Detection, Analysis And Isolation Of Nascent Proteins
patent-application, October 2011


Devices and Methods for Pharmacokinetic-Based Cell Culture System
patent-application, August 2012


Microfluidic Chip for High-Throughput Perfusion-Based Three-Dimensional Cell Culture
patent-application, September 2012


Biodetection Methods and Compositions
patent-application, August 2013