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Title: Broad spectrum antibiotic compounds and use thereof

The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is assembled outside of the host membrane is described. Also described is the identification of homologous NRPS gene clusters from several additional microorganisms. The secondary metabolites produced by the NRPS gene clusters exhibit broad spectrum antibiotic activity. Thus, antibiotic compounds produced by the NRPS gene clusters, and analogs thereof, their use for inhibiting bacterial growth, and methods of making the antibiotic compounds are described.
Inventors:
;
Issue Date:
OSTI Identifier:
1260252
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
Patent Number(s):
9,382,294
Application Number:
14/771,710
Contract Number:
AC52-06NA25396
Resource Relation:
Patent File Date: 2014 Feb 28
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Works referenced in this record:

Nonribosomal peptide synthetases: structures and dynamics
journal, April 2010
  • Strieker, Matthias; Tanović, Alan; Marahiel, Mohamed A.
  • Current Opinion in Structural Biology, Vol. 20, Issue 2, p. 234-240
  • DOI: 10.1016/j.sbi.2010.01.009