Microscale mass spectrometry systems, devices and related methods

Title: Microscale mass spectrometry systems, devices and related methods

Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm.sup.2 to about 25 cm.sup.2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.

Inventors:: Ramsey, John Michael

Issue Date:: 2016-06-21

OSTI Identifier:: 1258005

Assignee:: The University of North Carolina at Chapel Hill (Chapel Hill, NC) ORNL

Patent Number(s):: 9,373,492

Application Number:: 13/804,911

Contract Number:: AC05-00OR22725

Resource Relation:: Patent File Date: 2013 Mar 14

Research Org:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Full Text
View Full Text

Other works cited in this record:

Towards the hand-held mass spectrometer: design considerations, simulation, and fabrication of micrometer-scaled cylindrical ion traps
journal, August 2004

Blain, Matthew G.; Riter, Leah S.; Cruz, Dolores
International Journal of Mass Spectrometry, Vol. 236, Issue 1-3, p. 91-104
DOI: 10.1016/j.ijms.2004.06.011

High-pressure ion trap mass spectrometry
journal, July 2004

Whitten, William B.; Reilly, Peter T. A.; Ramsey, J. Michael
Rapid Communications in Mass Spectrometry, Vol. 18, Issue 15, p. 1749-1752
DOI: 10.1002/rcm.1549

Microfabricated Quadrupole Ion Trap for Mass Spectrometer Applications
journal, March 2006

Pau, S.; Pai, C. S.; Low, Y. L.
Physical Review Letters, Vol. 96, Issue 12, Article No. 120801
DOI: 10.1103/PhysRevLett.96.120801

Similar records in DOepatents and OSTI.GOV collections:

Microscale mass spectrometry systems, devices and related methods

Patent Ramsey, John Michael

Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm.sup.2 to about 25 cm.sup.2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.
Full Text Available April 2017
Devices, systems, and methods for microscale isoelectric fractionation

Patent Sommer, Gregory J ; Hatch, Anson V ; Wang, Ying-Chih ; Singh, Anup K

Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel betweenmore »« less
Full Text Available April 2015
Devices, systems, and methods for microscale isoelectric fractionation

Patent Sommer, Gregory J. ; Hatch, Anson V. ; Wang, Ying-Chih ; Singh, Anup K.

Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel betweenmore »« less
Full Text Available August 2016
Initiation devices, initiation systems including initiation devices and related methods

Patent Daniels, Michael A. ; Condit, Reston A. ; Rasmussen, Nikki ; Wallace, Ronald S.

Initiation devices may include at least one substrate, an initiation element positioned on a first side of the at least one substrate, and a spark gap electrically coupled to the initiation element and positioned on a second side of the at least one substrate. Initiation devices may include a plurality of substrates where at least one substrate of the plurality of substrates is electrically connected to at least one adjacent substrate of the plurality of substrates with at least one via extending through the at least one substrate. Initiation systems may include such initiation devices. Methods of igniting energetic materialsmore »« less
Full Text Available April 2018
Centrifugal separator devices, systems and related methods

Patent Meikrantz, David H ; Law, Jack D ; Garn, Troy G ; Todd, Terry A ; Macaluso, Lawrence L

Centrifugal separator devices, systems and related methods are described. More particularly, fluid transfer connections for a centrifugal separator system having support assemblies with a movable member coupled to a connection tube and coupled to a fixed member, such that the movable member is constrained to movement along a fixed path relative to the fixed member are described. Also, centrifugal separator systems including such fluid transfer connections are described. Additionally, methods of installing, removing and/or replacing centrifugal separators from centrifugal separator systems are described.
Full Text Available March 2012