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Title: Plume collimation for laser ablation electrospray ionization mass spectrometry

In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.
Inventors:
;
Issue Date:
OSTI Identifier:
1255956
Assignee:
The George Washington University CHO
Patent Number(s):
9,362,101
Application Number:
14/477,112
Contract Number:
FG02-01ER15129
Resource Relation:
Patent File Date: 2014 Sep 04
Research Org:
The George Washington University, Washington, DC (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Other works cited in this record:

Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
journal, October 2004

Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
journal, April 2005
  • Cody, Robert B.; Laramée, James A.; Durst, H. Dupont
  • Analytical Chemistry, Vol. 77, Issue 8, p. 2297-2302
  • DOI: 10.1021/ac050162j

Intact and top-down characterization of biomolecules and direct analysis using infrared matrix-assisted laser desorption electrospray ionization coupled to FT-ICR mass spectrometry
journal, April 2009
  • Sampson, Jason S.; Murray, Kermit K.; Muddiman, David C.
  • Journal of the American Society for Mass Spectrometry, Vol. 20, Issue 4, p. 667-673
  • DOI: 10.1016/j.jasms.2008.12.003

Matrix-assisted laser desorption and ionization in the OH and CO absorption bands of aliphatic and aromatic matrices: dependence on laser wavelength and temporal beam profile
journal, December 1997
  • Cramer, Rainer; Haglund, Richard F.; Hillenkamp, Franz
  • International Journal of Mass Spectrometry and Ion Processes, Vol. 169-170, p. 51-67
  • DOI: 10.1016/S0168-1176(97)00223-1

Method and system for desorption electrospray ionization
patent, February 2008

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