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Title: Plume collimation for laser ablation electrospray ionization mass spectrometry

Abstract

In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.

Inventors:
;
Issue Date:
Research Org.:
George Washington Univ., Washington, DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1255956
Patent Number(s):
9362101
Application Number:
14/477,112
Assignee:
The George Washington University
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
FG02-01ER15129
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 04
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Vertes, Akos, and Stolee, Jessica A. Plume collimation for laser ablation electrospray ionization mass spectrometry. United States: N. p., 2016. Web.
Vertes, Akos, & Stolee, Jessica A. Plume collimation for laser ablation electrospray ionization mass spectrometry. United States.
Vertes, Akos, and Stolee, Jessica A. Tue . "Plume collimation for laser ablation electrospray ionization mass spectrometry". United States. https://www.osti.gov/servlets/purl/1255956.
@article{osti_1255956,
title = {Plume collimation for laser ablation electrospray ionization mass spectrometry},
author = {Vertes, Akos and Stolee, Jessica A.},
abstractNote = {In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {6}
}

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Works referenced in this record:

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Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry
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Toward Single-Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry
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