Global to push GA events into
skip to main content

Title: Hybrid polyketide synthases

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
Inventors:
; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1252447
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,334,514
Application Number:
13/882,099
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2011 Oct 31
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Works referenced in this record:

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway
journal, June 2000

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
journal, March 2000

Biosynthesis of Nonribosomal Peptides
journal, October 2004

Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity
journal, April 2002
  • Jez, J. M.; Bowman, M. E.; Noel, J. P.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 8, p. 5319-5324
  • DOI: 10.1073/pnas.082590499

Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases
journal, September 2002
  • May, J. J.; Kessler, N.; Marahiel, M. A.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 19, p. 12120-12125
  • DOI: 10.1073/pnas.182156699

Unusual Chemistry in the Biosynthesis of the Antibiotic Chondrochlorens
journal, January 2009

Polyketide synthesis in vitro on a modular polyketide synthase
journal, September 1995
  • Wiesmann, Kirsten E. H.; Cortés, Jesus; Brown, Murray J. B.
  • Chemistry & Biology, Vol. 2, Issue 9, p. 583-589
  • DOI: 10.1016/1074-5521(95)90122-1