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Title: Hybrid polyketide synthases

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
Inventors:
; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1252447
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,334,514
Application Number:
13/882,099
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2011 Oct 31
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Works referenced in this record:

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Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
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Polyketide synthesis in vitro on a modular polyketide synthase
journal, September 1995
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  • DOI: 10.1016/1074-5521(95)90122-1

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