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Title: DNA-cell conjugates

The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
Inventors:
; ; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1250470
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,327,036
Application Number:
13/263,129
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2010 Apr 08
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Programmable Cell Adhesion Encoded by DNA Hybridization
journal, January 2006
  • Chandra, Ravi A.; Douglas, Erik S.; Mathies, Richard A.
  • Angewandte Chemie International Edition, Vol. 45, Issue 6, p. 896-901
  • DOI: 10.1002/anie.200502421

DNA-Coated AFM Cantilevers for the Investigation of Cell Adhesion and the Patterning of Live Cells
journal, October 2008
  • Hsiao, Sonny C.; Crow, Ailey K.; Lam, Wilbur A.
  • Angewandte Chemie International Edition, Vol. 47, Issue 44, p. 8473-8477
  • DOI: 10.1002/anie.200802525

Behavior of synthetic polymers immobilized on a cell membrane
journal, April 2008

Integrated microfluidic bioprocessor for single-cell gene expression analysis
journal, December 2008
  • Toriello, N. M.; Douglas, E. S.; Thaitrong, N.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 51, p. 20173-20178
  • DOI: 10.1073/pnas.0806355106

A Universal Method for the Preparation of Covalent Protein–DNA Conjugates for Use in Creating Protein Nanostructures
journal, November 2007
  • Duckworth, Benjamin P.; Chen, Yan; Wollack, James W.
  • Angewandte Chemie International Edition, Vol. 46, Issue 46, p. 8819-8822
  • DOI: 10.1002/anie.200701942

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