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Title: Microfluidic ultrasonic particle separators with engineered node locations and geometries

Abstract

An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.

Inventors:
; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1248912
Patent Number(s):
9321050
Application Number:
14/659,825
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Mar 17
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS

Citation Formats

Rose, Klint A., Fisher, Karl A., Wajda, Douglas A., Mariella, Jr., Raymond P., Bailey, Christopher, Dehlinger, Dietrich, Shusteff, Maxim, Jung, Byoungsok, and Ness, Kevin D. Microfluidic ultrasonic particle separators with engineered node locations and geometries. United States: N. p., 2016. Web.
Rose, Klint A., Fisher, Karl A., Wajda, Douglas A., Mariella, Jr., Raymond P., Bailey, Christopher, Dehlinger, Dietrich, Shusteff, Maxim, Jung, Byoungsok, & Ness, Kevin D. Microfluidic ultrasonic particle separators with engineered node locations and geometries. United States.
Rose, Klint A., Fisher, Karl A., Wajda, Douglas A., Mariella, Jr., Raymond P., Bailey, Christopher, Dehlinger, Dietrich, Shusteff, Maxim, Jung, Byoungsok, and Ness, Kevin D. Tue . "Microfluidic ultrasonic particle separators with engineered node locations and geometries". United States. https://www.osti.gov/servlets/purl/1248912.
@article{osti_1248912,
title = {Microfluidic ultrasonic particle separators with engineered node locations and geometries},
author = {Rose, Klint A. and Fisher, Karl A. and Wajda, Douglas A. and Mariella, Jr., Raymond P. and Bailey, Christopher and Dehlinger, Dietrich and Shusteff, Maxim and Jung, Byoungsok and Ness, Kevin D.},
abstractNote = {An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {4}
}

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Works referenced in this record:

Modeling the acoustic radiation force in microfluidic chambers
journal, April 2008


Multi-modal particle manipulator to enhance bead-based bioassays
journal, February 2010


Filtration of bacteria and yeast by ultrasound-enhanced sedimentation
journal, January 1997


Acoustic Particle Filter with Adjustable Effective Pore Size for Automated Sample Preparation
journal, November 2008


Chip integrated strategies for acoustic separation and manipulation of cells and particles
journal, January 2007