skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

Abstract

Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
BROWN UNIVERSITY, Providence, RI (United States) RHODE ISLAND HOSPITAL, Providence, RI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1247995
Patent Number(s):
9316645
Application Number:
13/645,938
Assignee:
BROWN UNIVERSITY (Providence, RI) RHODE ISLAND HOSPITAL (Providence, RI)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
DOE Contract Number:  
FG02-08ER15937
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Oct 05
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Rose-Petruck, Christoph, Wands, Jack R., Rand, Danielle, Derdak, Zoltan, and Ortiz, Vivian. Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging. United States: N. p., 2016. Web.
Rose-Petruck, Christoph, Wands, Jack R., Rand, Danielle, Derdak, Zoltan, & Ortiz, Vivian. Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging. United States.
Rose-Petruck, Christoph, Wands, Jack R., Rand, Danielle, Derdak, Zoltan, and Ortiz, Vivian. Tue . "Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging". United States. https://www.osti.gov/servlets/purl/1247995.
@article{osti_1247995,
title = {Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging},
author = {Rose-Petruck, Christoph and Wands, Jack R. and Rand, Danielle and Derdak, Zoltan and Ortiz, Vivian},
abstractNote = {Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {4}
}

Patent:

Save / Share:

Works referenced in this record:

Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique
journal, January 2010


Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
journal, May 2008


Quantitative Evaluation of Cellular Uptake and Trafficking of Plain and Polyethylene Glycol-Coated Gold Nanoparticles
journal, July 2010


New aspects of diagnosis and therapy of hepatocellular carcinoma
journal, June 2006


A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors
journal, December 2007


Rising Incidence of Hepatocellular Carcinoma in the United States
journal, March 1999


Tailoring the Polyelectrolyte Coating of Metal Nanoparticles
journal, July 2001


Polyelectrolyte-Coated Gold Nanorods:  Synthesis, Characterization and Immobilization
journal, March 2005


The use of gold nanoparticles to enhance radiotherapy in mice
journal, September 2004


Gold nanoparticles: a new X-ray contrast agent
journal, March 2006


Monoclonal antibody G6K12 specific for membrane-associated differentiation marker of human stratified squamous epithelia and squamous cell carcinoma
journal, April 1993


Establishment and characterization of a new human hepatocellular carcinoma cell line
journal, June 1984


Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
journal, November 2003


In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins
journal, June 2009


A conjugate of 5-fluorouridine-poly(L-lysine) and an antibody reactive with human colon carcinoma
journal, July 1990


Immunohistochemical detection of an enamel protein-related epitope in rat bone at an early stage of osteogenesis
journal, May 1993


Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene
journal, August 1982


Antibiofouling Polymer-Coated Gold Nanoparticles as a Contrast Agent for in Vivo X-ray Computed Tomography Imaging
journal, June 2007


Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact
journal, December 2008


Blood compatibility of polyethylene oxide surfaces
journal, January 1995


Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
journal, September 2010


Prognostic value of aspartyl (asparaginyl)-β-hydroxylase/humbug expression in non–small cell lung carcinoma
journal, May 2009


Preparation and Organization of Nanoscale Polyelectrolyte-Coated Gold Nanoparticles
journal, March 2003


Rational Design of Cytophilic and Cytophobic Polyelectrolyte Multilayer Thin Films
journal, January 2003


pH-Dependent Thickness Behavior of Sequentially Adsorbed Layers of Weak Polyelectrolytes
journal, May 2000


Rapid generation of monoclonal antibody-secreting hybridomas against African horse sickness virus by in vitro immunization and the fusion/cloning technique
journal, May 1993


Recent advances in the natural history of hepatocellular carcinoma
journal, May 2008


Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.
journal, July 1980


Production of Anti-Fibroblast Growth Factor Receptor Monoclonal Antibodies by In Vitro Immunization
journal, December 1992


Spatial Harmonic Imaging of X-ray Scattering—Initial Results
journal, August 2008


Fourier X-ray Scattering Radiography Yields Bone Structural Information
journal, June 2009


Vapor phase synthesis of supported Pd, Au, and unsupported bimetallic nanoparticle catalysts for CO oxidation
journal, May 2006