Global to push GA events into
skip to main content

Title: Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1247995
Assignee:
BROWN UNIVERSITY (Providence, RI) RHODE ISLAND HOSPITAL (Providence, RI) CHO
Patent Number(s):
9,316,645
Application Number:
13/645,938
Contract Number:
FG02-08ER15937
Resource Relation:
Patent File Date: 2012 Oct 05
Research Org:
BROWN UNIVERSITY, Providence, RI (United States) RHODE ISLAND HOSPITAL, Providence, RI (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Other works cited in this record:

A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors
journal, December 2007
  • Choi, Mi-Ran; Stanton-Maxey, Katie J.; Stanley, Jennifer K.
  • Nano Letters, Vol. 7, Issue 12, p. 3759-3765
  • DOI: 10.1021/nl072209h

Monoclonal antibody G6K12 specific for membrane-associated differentiation marker of human stratified squamous epithelia and squamous cell carcinoma
journal, April 1993

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
journal, November 2003
  • Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 23, p. 13549-13554
  • DOI: 10.1073/pnas.2232479100

In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins
journal, June 2009
  • Hucknall, Angus; Rangarajan, Srinath; Chilkoti, Ashutosh
  • Advanced Materials, Vol. 21, Issue 23, p. 2441-2446
  • DOI: 10.1002/adma.200900383

Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene
journal, August 1982

Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact
journal, December 2008
  • Lal, Surbhi; Clare, Susan E.; Halas, Naomi J.
  • Accounts of Chemical Research, Vol. 41, Issue 12, p. 1842-1851
  • DOI: 10.1021/ar800150g

Blood compatibility of polyethylene oxide surfaces
journal, January 1995
  • Lee, Jin Ho; Lee, Hai Bang; Andrade, Joseph D.
  • Progress in Polymer Science, Vol. 20, Issue 6, p. 1043-1079
  • DOI: 10.1016/0079-6700(95)00011-4

Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
journal, September 2010

Prognostic value of aspartyl (asparaginyl)-β-hydroxylase/humbug expression in non–small cell lung carcinoma
journal, May 2009

Preparation and Organization of Nanoscale Polyelectrolyte-Coated Gold Nanoparticles
journal, March 2003
  • Mayya, K. S.; Schoeler, B.; Caruso, F.
  • Advanced Functional Materials, Vol. 13, Issue 3, p. 183-188
  • DOI: 10.1002/adfm.200390028

Characterization of two human monoclonal antibodies reactive with HLA-B12 and HLA-B60, respectively, raised by in vitro secondary immunization of peripheral blood lymphocytes
journal, March 1993

Early detection of hepatocellular carcinoma by real-time ultrasonography. A prospective study
journal, August 1985

Rapid generation of monoclonal antibody-secreting hybridomas against African horse sickness virus by in vitro immunization and the fusion/cloning technique
journal, May 1993
  • Stäuber, Norbert; Kihm, Ulrich; McCullough, Kenneth C.
  • Journal of Immunological Methods, Vol. 161, Issue 2, p. 157-168
  • DOI: 10.1016/0022-1759(93)90291-E

Vapor phase synthesis of supported Pd, Au, and unsupported bimetallic nanoparticle catalysts for CO oxidation
journal, May 2006
  • Yang, Yonglai; Saoud, Khaled M.; Abdelsayed, Victor
  • Catalysis Communications, Vol. 7, Issue 5, p. 281-284
  • DOI: 10.1016/j.catcom.2005.11.014

Similar records in DOepatents and OSTI.GOV collections: