Title: Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

Abstract

Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.

Inventors:

Rose-Petruck, Christoph; Wands, Jack R.; Rand, Danielle; Derdak, Zoltan; Ortiz, Vivian

Issue Date:

2016-04-19

Research Org.:

BROWN UNIVERSITY, Providence, RI (United States) RHODE ISLAND HOSPITAL, Providence, RI (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1247995

Patent Number(s):

9316645

Application Number:

13/645,938

Assignee:

BROWN UNIVERSITY (Providence, RI) RHODE ISLAND HOSPITAL (Providence, RI)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K49/0428 - {Surface-modified nanoparticles, e.g. immuno-nanoparticles}

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2500/00 - Screening for compounds of potential therapeutic value
G01N33/5011 - {for testing antineoplastic activity}
G01N33/56966 - {Animal cells}
G01N33/574 - for cancer
G01N33/57438 - {of liver, pancreas or kidney}
G01N33/57484 - {involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites}

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DOE Contract Number:  

FG02-08ER15937

Resource Type:

Patent

Resource Relation:

Patent File Date: 2012 Oct 05

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY