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Title: Detecting and treating breast cancer resistance to EGFR inhibitors

Abstract

The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1245595
Patent Number(s):
9303088
Application Number:
13/248,690
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Sep 29
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Moonlee, Sun-Young, Bissell, Mina J., Furuta, Saori, Meier, Roland, and Kenny, Paraic A.. Detecting and treating breast cancer resistance to EGFR inhibitors. United States: N. p., 2016. Web.
Moonlee, Sun-Young, Bissell, Mina J., Furuta, Saori, Meier, Roland, & Kenny, Paraic A.. Detecting and treating breast cancer resistance to EGFR inhibitors. United States.
Moonlee, Sun-Young, Bissell, Mina J., Furuta, Saori, Meier, Roland, and Kenny, Paraic A.. Tue . "Detecting and treating breast cancer resistance to EGFR inhibitors". United States. https://www.osti.gov/servlets/purl/1245595.
@article{osti_1245595,
title = {Detecting and treating breast cancer resistance to EGFR inhibitors},
author = {Moonlee, Sun-Young and Bissell, Mina J. and Furuta, Saori and Meier, Roland and Kenny, Paraic A.},
abstractNote = {The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {4}
}

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Works referenced in this record:

Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer
journal, January 2009


Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines
journal, March 1987


FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
journal, September 2012