skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Photosynthetic microorganisms expressing thermostable lipase

Abstract

The present invention encompasses a photosynthetic microorganism that produces biofuels and biofuel precursors.

Inventors:
;
Issue Date:
Research Org.:
The Arizona Board of Regents for and on Behalf of Arizona State University, Tempe, AZ (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1245593
Patent Number(s):
9,303,264
Application Number:
13/898,241
Assignee:
The Arizona Board of Regents for and on Behalf of Arizona State University (Tempe, AZ)
DOE Contract Number:  
AR0000011
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 May 20
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 09 BIOMASS FUELS

Citation Formats

Curtiss, Roy, and Liu, Xinyao. Photosynthetic microorganisms expressing thermostable lipase. United States: N. p., 2016. Web.
Curtiss, Roy, & Liu, Xinyao. Photosynthetic microorganisms expressing thermostable lipase. United States.
Curtiss, Roy, and Liu, Xinyao. Tue . "Photosynthetic microorganisms expressing thermostable lipase". United States. https://www.osti.gov/servlets/purl/1245593.
@article{osti_1245593,
title = {Photosynthetic microorganisms expressing thermostable lipase},
author = {Curtiss, Roy and Liu, Xinyao},
abstractNote = {The present invention encompasses a photosynthetic microorganism that produces biofuels and biofuel precursors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {4}
}

Patent:

Save / Share:

Works referenced in this record:

Lipase protein engineering
journal, December 2000

  • Svendsen, Allan
  • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1543, Issue 2, p. 223-238
  • DOI: 10.1016/S0167-4838(00)00239-9

CO2-limitation-inducible Green Recovery of fatty acids from cyanobacterial biomass
journal, April 2011

  • Liu, X.; Fallon, S.; Sheng, J.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 17, p. 6905-6908
  • DOI: 10.1073/pnas.1103016108

Nickel-inducible lysis system in Synechocystis sp. PCC 6803
journal, December 2009

  • Liu, X.; Curtiss, R.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 51, p. 21550-21554
  • DOI: 10.1073/pnas.0911953106

Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit
journal, January 1994


Influenza A (H5N1): Will It Be the Next Pandemic Influenza? Are We Ready?
journal, September 2005


Planning for Avian Influenza
journal, July 2006


DNA repair is more important than catalase for Salmonella virulence in mice.
journal, March 1995

  • Buchmeier, N. A.; Libby, S. J.; Xu, Y.
  • Journal of Clinical Investigation, Vol. 95, Issue 3
  • DOI: 10.1172/JCI117750

Enteric Pathogens as Vaccine Vectors for Foreign Antigen Delivery
journal, September 2004


Characterization of recent H5 subtype avian influenza viruses from US poultry
journal, June 2004


Mechanism of araC autoregulation and the domains of two overlapping promoters, Pc and PBAD, in the L-arabinose regulatory region of Escherichia coli.
journal, February 1981

  • Lee, N. L.; Gielow, W. O.; Wallace, R. G.
  • Proceedings of the National Academy of Sciences, Vol. 78, Issue 2
  • DOI: 10.1073/pnas.78.2.752

Trigger Factor Retards Protein Export in Escherichia coli
journal, August 2002

  • Lee, Hin C.; Bernstein, Harris D.
  • Journal of Biological Chemistry, Vol. 277, Issue 45
  • DOI: 10.1074/jbc.M205950200

Th1-Directing Adjuvants Increase the Immunogenicity of Oligosaccharide-Protein Conjugate Vaccines Related to Streptococcus pneumoniae Type 3
journal, November 2003


Differential effect of auxotrophies on the release of macromolecules by Salmonella enterica vaccine strains
journal, December 2006


Amplification, expression, and packaging of a foreign gene by influenza virus
journal, December 1989


CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization
journal, March 2005

  • Malley, R.; Trzcinski, K.; Srivastava, A.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 13, p. 4848-4853
  • DOI: 10.1073/pnas.0501254102

Cloning of the Chicken RNA Polymerase I Promoter and Use for Reverse Genetics of Influenza A Viruses in Avian Cells
journal, October 2005


Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
journal, October 2001

  • McClelland, Michael; Sanderson, Kenneth E.; Spieth, John
  • Nature, Vol. 413, Issue 6858
  • DOI: 10.1038/35101614

Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA)
journal, February 1987


Bacteriophage T4 Genome
journal, March 2003


The annual impact of seasonal influenza in the US: Measuring disease burden and costs
journal, June 2007

  • Molinari, Noelle-Angelique M.; Ortega-Sanchez, Ismael R.; Messonnier, Mark L.
  • Vaccine, Vol. 25, Issue 27, p. 5086-5096
  • DOI: 10.1016/j.vaccine.2007.03.046

Localization of RNA polymerases on influenza viral ribonucleoproteins by immunogold labeling
journal, June 1988


An improved reverse genetics system for influenza A virus generation and its implications for vaccine production
journal, November 2005

  • Neumann, G.; Fujii, K.; Kino, Y.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 46, p. 16825-16829
  • DOI: 10.1073/pnas.0505587102

Generation of influenza A viruses entirely from cloned cDNAs
journal, August 1999

  • Neumann, G.; Watanabe, T.; Ito, H.
  • Proceedings of the National Academy of Sciences, Vol. 96, Issue 16
  • DOI: 10.1073/pnas.96.16.9345

RNA Polymerase I-Mediated Expression of Influenza Viral RNA Molecules
journal, July 1994


Architecture of ribonucleoprotein complexes in influenza A virus particles
journal, January 2006

  • Noda, Takeshi; Sagara, Hiroshi; Yen, Albert
  • Nature, Vol. 439, Issue 7075
  • DOI: 10.1038/nature04378

Contributions of Pneumolysin, Pneumococcal Surface Protein A (PspA), and PspC to Pathogenicity of Streptococcus pneumoniae D39 in a Mouse Model
journal, January 2007

  • Ogunniyi, A. D.; LeMessurier, K. S.; Graham, R. M. A.
  • Infection and Immunity, Vol. 75, Issue 4
  • DOI: 10.1128/IAI.01384-06

Preparing for the Next Pandemic
journal, May 2005

  • Osterholm, Michael T.
  • New England Journal of Medicine, Vol. 352, Issue 18
  • DOI: 10.1056/NEJMp058068

Generation of High-Yielding Influenza A Viruses in African Green Monkey Kidney (Vero) Cells by Reverse Genetics
journal, January 2004


Engineered viral vaccine constructs with dual specificity: Avian influenza and Newcastle disease
journal, May 2006

  • Park, M.-S.; Steel, J.; Garcia-Sastre, A.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 21, p. 8203-8208
  • DOI: 10.1073/pnas.0602566103

Th1 dominance in the immune response to live Salmonella typhimurium requires bacterial invasiveness but not persistence
journal, April 1999

  • Pashine, Achal; John, Beena; Rath, Satyajit
  • International Immunology, Vol. 11, Issue 4
  • DOI: 10.1093/intimm/11.4.481

RpoS Proteolysis Is Regulated by a Mechanism That Does Not Require the SprE (RssB) Response Regulator Phosphorylation Site
journal, October 2004


The bacterial signal molecule, ppGpp, regulates Salmonella virulence gene expression
journal, May 2004


Salmonella enterica Serovar Typhimurium Invasion Is Repressed in the Presence of Bile
journal, December 2000


Attenuation of Equine Influenza Viruses through Truncations of the NS1 Protein
journal, June 2005


Crystal violet can be used to visualize DNA bands during gel electrophoresis and to improve cloning efficiency
journal, January 1996


Serum Samples from Infants Vaccinated with a Pneumococcal Conjugate Vaccine, PncT, Protect Mice against Invasive Infection Caused by Streptococcus pneumoniae Serotypes 6A and 6B
journal, January 2001

  • Saeland, Eirikur; Jakobsen, Håvard; Ingolfsdottir, Gunnhildur
  • The Journal of Infectious Diseases, Vol. 183, Issue 2
  • DOI: 10.1086/317934

Construction of self-disruptive Bacillus megaterium in response to substrate exhaustion for polyhydroxybutyrate production
journal, July 2002


Bacterial Meningitis in the United States in 1995
journal, October 1997

  • Schuchat, Anne; Robinson, Katherine; Wenger, Jay D.
  • New England Journal of Medicine, Vol. 337, Issue 14
  • DOI: 10.1056/NEJM199710023371404

Independent Variation in Nature of Hemagglutinin and Neuraminidase Antigens of Influenza Virus: Distinctiveness of Hemagglutinin Antigen of hong Kong/68 Virus
journal, June 1969

  • Schulman, J. L.; Kilbourne, E. D.
  • Proceedings of the National Academy of Sciences, Vol. 63, Issue 2
  • DOI: 10.1073/pnas.63.2.326

The Impact of Influenza Epidemics on Hospitalizations
journal, March 2000

  • Simonsen, Lone; Fukuda, Keiji; Schonberger, Lawrence B.
  • The Journal of Infectious Diseases, Vol. 181, Issue 3
  • DOI: 10.1086/315320

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence
journal, February 2007

  • Rytkonen, A.; Poh, J.; Garmendia, J.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 9, p. 3502-3507
  • DOI: 10.1073/pnas.0610095104

The role of polyadenylation signal secondary structures on the resistance of plasmid vectors to nucleases
journal, May 2004

  • Ribeiro, Sofia C.; Monteiro, Gabriel A.; Prazeres, Duarte M. F.
  • The Journal of Gene Medicine, Vol. 6, Issue 5
  • DOI: 10.1002/jgm.536

Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae
journal, June 2001


The Role of relA and spoT in Yersinia pestis KIM5+ Pathogenicity
journal, August 2009


The Bacterial Signal Molecule, ppGpp, Mediates the Environmental Regulation of Both the Invasion and Intracellular Virulence Gene Programs of Salmonella
journal, August 2006

  • Thompson, Arthur; Rolfe, Matthew D.; Lucchini, Sacha
  • Journal of Biological Chemistry, Vol. 281, Issue 40
  • DOI: 10.1074/jbc.M605616200

Epitope tagging of chromosomal genes in Salmonella
journal, December 2001

  • Uzzau, S.; Figueroa-Bossi, N.; Rubino, S.
  • Proceedings of the National Academy of Sciences, Vol. 98, Issue 26, p. 15264-15269
  • DOI: 10.1073/pnas.261348198

YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis
journal, October 2005


Biosynthesis and Assembly of Capsular Polysaccharides in Escherichia coli
journal, June 2006


The Salmonella enterica serotype Typhi regulator TviA reduces interleukin-8 production in intestinal epithelial cells by repressing flagellin secretion
journal, August 2007


A One-Plasmid System To Generate Influenza Virus in Cultured Chicken Cells for Potential Use in Influenza Vaccine
journal, July 2009


Transcription Activation Parameters atara pBAD
journal, April 1996

  • Zhang, Xin; Reeder, Thadd; Schleif, Robert
  • Journal of Molecular Biology, Vol. 258, Issue 1
  • DOI: 10.1006/jmbi.1996.0230

Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity
journal, April 1997


PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice
journal, June 1996


Antibacterial activity of Bacillus amyloliquefaciens phage endolysin without holin conjugation
journal, January 2001

  • Morita, Masatomo; Tanji, Yasunori; Mizoguchi, Katsunori
  • Journal of Bioscience and Bioengineering, Vol. 91, Issue 5, p. 469-473
  • DOI: 10.1016/S1389-1723(01)80275-9

Immunization with the C‐Domain of α‐Toxin Prevents Lethal Infection, Localizes Tissue Injury, and Promotes Host Response to Challenge with Clostridium perfringens
journal, August 2004

  • Stevens, Dennis L.; Titball, Richard W.; Jepson, Marie
  • The Journal of Infectious Diseases, Vol. 190, Issue 4
  • DOI: 10.1086/422691

Genetic Loci of Major Antigenic Protein Genes of Edwardsiella tarda
journal, September 2005


Defining epitopes: It's not as easy as it seems
journal, October 1999

  • Greenspan, Neil S.; Di Cera, Enrico
  • Nature Biotechnology, Vol. 17, Issue 10
  • DOI: 10.1038/13590

RpoS and RpoN are involved in the growth-dependent regulation of rfaH transcription and O antigen expression in Salmonella enterica serovar typhi
journal, January 2004

  • Bittner, Mauricio; Saldı́as, Soledad; Altamirano, Francisco
  • Microbial Pathogenesis, Vol. 36, Issue 1, p. 19-24
  • DOI: 10.1016/j.micpath.2003.08.003

Salmonella Synthesizing 1-Monophosphorylated Lipopolysaccharide Exhibits Low Endotoxic Activity while Retaining Its Immunogenicity
journal, June 2011

  • Kong, Qingke; Six, David A.; Roland, Kenneth L.
  • The Journal of Immunology, Vol. 187, Issue 1
  • DOI: 10.4049/jimmunol.1100339

Salmonella as Live Trojan Horse for Vaccine Development and Cancer Gene Therapy
journal, February 2010


Type 1/Type 2 Immunity in Infectious Diseases
journal, January 2001

  • Spellberg, B.; Edwards, J. E.
  • Clinical Infectious Diseases, Vol. 32, Issue 1
  • DOI: 10.1086/317537

Sequence of the Genome of Salmonella Bacteriophage P22
journal, November 2000


Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 Highly Pathogenic Avian Influenza
journal, December 2008


1918 Influenza: the Mother of All Pandemics
journal, January 2006

  • Taubenberger, Jeffery K.; Morens, David M.
  • Emerging Infectious Diseases, Vol. 12, Issue 1
  • DOI: 10.3201/eid1209.05-0979

The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica
journal, August 2006

  • Tu, X.; Latifi, T.; Bougdour, A.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 36, p. 13503-13508
  • DOI: 10.1073/pnas.0606026103

Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus
journal, October 2005


Host and Bacterial Factors Contributing to the Clearance of Colonization by Streptococcus pneumoniae in a Murine Model
journal, October 2005


RNA polymerase I catalysed transcription of insert viral cDNA
journal, January 1993

  • Zobel, Alexandra; Neumann, Gabriele; Hobom, Gerd
  • Nucleic Acids Research, Vol. 21, Issue 16
  • DOI: 10.1093/nar/21.16.3607

Leucine-Responsive Regulatory Protein (Lrp) Acts as a Virulence Repressor in Salmonella enterica Serovar Typhimurium
journal, December 2008

  • Baek, C. -H.; Wang, S.; Roland, K. L.
  • Journal of Bacteriology, Vol. 191, Issue 4
  • DOI: 10.1128/JB.01142-08

Stabilization of recombinant avirulent vaccine strains in vivo
journal, September 1990


A Regulatory Cascade in the Induction of rhaBAD
journal, November 1993

  • Egan, Susan M.; Schleif, Robert F.
  • Journal of Molecular Biology, Vol. 234, Issue 1
  • DOI: 10.1006/jmbi.1993.1565

Recombinant avirulent Salmonellae as oral vaccine carriers
journal, January 1992


Oral Immunization with Attenuated Salmonella Expressing Human Sperm Antigen Induces Antibodies in Serum and the Reproductive Tract1
journal, August 1995


A Regulated, NFκB-Assisted Import of Plasmid DNA into Mammalian Cell Nuclei
journal, May 2001


Yersinia pestis caf1 Variants and the Limits of Plague Vaccine Protection
journal, March 2008

  • Quenee, L. E.; Cornelius, C. A.; Ciletti, N. A.
  • Infection and Immunity, Vol. 76, Issue 5
  • DOI: 10.1128/IAI.00105-08

Expression of the Rickettsia prowazekii pld or tlyC Gene in Salmonella enterica Serovar Typhimurium Mediates Phagosomal Escape
journal, September 2005


Temperature has reciprocal effects on colanic acid and polysialic acid biosynthesis in E. coli K92
journal, January 2009

  • Navasa, Nicolás; Rodríguez-Aparicio, Leandro; Martínez-Blanco, Honorina
  • Applied Microbiology and Biotechnology, Vol. 82, Issue 4
  • DOI: 10.1007/s00253-008-1840-4

Genetic mapping of the cold-adapted phenotype of B/Ann Arbor/1/66, the master donor virus for live attenuated influenza vaccines (FluMist®)
journal, February 2006


Highly Efficient Method for Introducing Successive Multiple Scarless Gene Deletions and Markerless Gene Insertions into the Yersinia pestis Chromosome
journal, May 2008

  • Sun, W.; Wang, S.; Curtiss, R.
  • Applied and Environmental Microbiology, Vol. 74, Issue 13
  • DOI: 10.1128/AEM.00940-08

Salmonella enterica Serovar Typhimurium Strains with Regulated Delayed Attenuation In Vivo
journal, December 2008

  • Curtiss, R.; Wanda, S. -Y.; Gunn, B. M.
  • Infection and Immunity, Vol. 77, Issue 3
  • DOI: 10.1128/IAI.00693-08

Bacterial infectious disease control by vaccine development
journal, October 2002

  • Curtiss, Roy
  • Journal of Clinical Investigation, Vol. 110, Issue 8
  • DOI: 10.1172/JCI16941

Import of Plasmid DNA into the Nucleus Is Sequence Specific
journal, February 1997


The W-Beijing Lineage of Mycobacterium tuberculosis Overproduces Triglycerides and Has the DosR Dormancy Regulon Constitutively Upregulated
journal, January 2007

  • Reed, M. B.; Gagneux, S.; DeRiemer, K.
  • Journal of Bacteriology, Vol. 189, Issue 7
  • DOI: 10.1128/JB.01670-06

Introduction of site-specific mutations into the genome of influenza virus.
journal, May 1990

  • Enami, M.; Luytjes, W.; Krystal, M.
  • Proceedings of the National Academy of Sciences, Vol. 87, Issue 10
  • DOI: 10.1073/pnas.87.10.3802

Antibiotic-Free Plasmid Stabilization by Operator-Repressor Titration for Vaccine Delivery by Using Live Salmonella enterica Serovar Typhimurium
journal, March 2005


The annual production cycle for influenza vaccine
journal, May 2003


Candidate Live, Attenuated Salmonella enterica Serotype Typhimurium Vaccines with Reduced Fecal Shedding Are Immunogenic and Effective Oral Vaccines
journal, February 2007

  • Abd El Ghany, M.; Jansen, A.; Clare, S.
  • Infection and Immunity, Vol. 75, Issue 4
  • DOI: 10.1128/IAI.01655-06

The epidemiology of pneumococcal infection in children in the developing world
journal, April 1999

  • Greenwood, Brian
  • Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 354, Issue 1384
  • DOI: 10.1098/rstb.1999.0430

Incidence of Pneumococcal Disease Due to Non–Pneumococcal Conjugate Vaccine (PCV7) Serotypes in the United States during the Era of Widespread PCV7 Vaccination, 1998–2004
journal, November 2007

  • Hicks, Lauri A.; Harrison, Lee H.; Flannery, Brendan
  • The Journal of Infectious Diseases, Vol. 196, Issue 9
  • DOI: 10.1086/521626

“Ambisense” Approach for the Generation of Influenza A Virus: vRNA and mRNA Synthesis from One Template
journal, February 2000


Macrophage-inducible expression of a model antigen in Salmonella typhimurium enhances immunogenicity.
journal, March 1995

  • Hohmann, E. L.; Oletta, C. A.; Loomis, W. P.
  • Proceedings of the National Academy of Sciences, Vol. 92, Issue 7
  • DOI: 10.1073/pnas.92.7.2904

Diversity of PspA: Mosaic Genes and Evidence for Past Recombination in Streptococcus pneumoniae
journal, October 2000


Immune responses dependent on antigen location in recombinant attenuated Salmonella typhimurium vaccines following oral immunization
journal, July 2003


Transduction-Mediated Transfer of Unmarked Deletion and Point Mutations through Use of Counterselectable Suicide Vectors
journal, January 2002


Invertebrate connective tissue. Isolation of d-arabinose from sponge acidic polysaccharide
journal, August 1970

  • Katzman, Richard L.; Lisowska, Elwira; Jeanloz, Roger W.
  • Biochemical Journal, Vol. 119, Issue 1
  • DOI: 10.1042/bj1190017

A Proteinaceous Gene Regulatory Thermometer in Salmonella
journal, July 1997


Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment
journal, July 2008

  • Kong, W.; Wanda, S.-Y.; Zhang, X.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 27, p. 9361-9366
  • DOI: 10.1073/pnas.0803801105

A Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Encoding Eimeria acervulina Antigen Offers Protection against E. acervulina Challenge
journal, September 2006

  • Konjufca, V.; Wanda, S. -Y.; Jenkins, M. C.
  • Infection and Immunity, Vol. 74, Issue 12
  • DOI: 10.1128/IAI.00851-06

Evaluation of a phoP/phoQ-deleted, aroA-deleted live oral Salmonella typhi vaccine strain in human volunteers
journal, January 1996


The inducible lac operator-repressor system is functional for control of expression of injected DNA in Xenopus oocytes
journal, February 1988


Genome-Wide Screen of Salmonella Genes Expressed during Infection in Pigs, Using In Vivo Expression Technology
journal, October 2007

  • Huang, Y.; Leming, C. L.; Suyemoto, M.
  • Applied and Environmental Microbiology, Vol. 73, Issue 23
  • DOI: 10.1128/AEM.01481-07

Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae
journal, February 2002


Expression of a Porphyromonas gingivalis hemagglutinin on the surface of a Salmonella vaccine vector
journal, January 2007


Effects of recJ, recQ, and recFOR Mutations on Recombination in Nuclease-Deficient recB recD Double Mutants of Escherichia coli
journal, February 2005


Impact of intracellular location of and antigen display by intracellular bacteria: implications for vaccine development
journal, January 1999


Immunogenicity and protective efficacy of DnaJ (hsp40) of Streptococcus pneumoniae against lethal infection in mice
journal, September 2006


Direct Transcriptional Control of the Plasminogen Activator Gene of Yersinia pestis by the Cyclic AMP Receptor Protein
journal, October 2007

  • Kim, T. -J.; Chauhan, S.; Motin, V. L.
  • Journal of Bacteriology, Vol. 189, Issue 24
  • DOI: 10.1128/JB.00972-07

Regulation of the l-arabinose transport operons in Escherichia coli
journal, September 1981


Salmonella -based vaccines for infectious diseases
journal, April 2007

  • Kwon, Young Min; Cox, Mandy M.; Calhoun, Leona N.
  • Expert Review of Vaccines, Vol. 6, Issue 2
  • DOI: 10.1586/14760584.6.2.147

Identification of a central regulator of stationary-phase gene expression in Escherichia coli
journal, January 1991


Regulation of L-arabinose transport in Salmonella typhimurium LT2
journal, March 1982

  • Lee, Jar-How; Russo, Robert J.; Heffernan, Laurel
  • MGG Molecular & General Genetics, Vol. 185, Issue 1
  • DOI: 10.1007/BF00333803

Surface-displayed viral antigens on Salmonella carrier vaccine
journal, June 2000

  • Lee, Jong-Soo; Shin, Kwang-Soon; Pan, Jae-Gu
  • Nature Biotechnology, Vol. 18, Issue 6
  • DOI: 10.1038/76494

The lac repressor
journal, June 2005


AraC-DNA looping: Orientation and distance-dependent loop breaking by the cyclic AMP receptor protein
journal, March 1991


Bacteria-mediated DNA transfer in gene therapy and vaccination
journal, February 2004

  • Loessner, Holger; Weiss, Siegfried
  • Expert Opinion on Biological Therapy, Vol. 4, Issue 2
  • DOI: 10.1517/14712598.4.2.157

Use of the stationary phase inducible promoters, spv and dps, to drive heterologous antigen expression in Salmonella vaccine strains
journal, February 2000


Use of live bacterial vaccine vectors for antigen delivery: potential and limitations
journal, February 2001


Expression of the low calcium response in Yersinia pestis
journal, March 1989

  • Mehigh, Richard J.; Sample, Allen K.; Brubaker, Robert R.
  • Microbial Pathogenesis, Vol. 6, Issue 3, p. 203-217
  • DOI: 10.1016/0882-4010(89)90070-3

Enhanced protective immunity against pneumococcal infection with PspA DNA and protein
journal, July 2006


Upstream operators enhance repression of the lac promoter
journal, August 1986


Repression oflacPromoter as a Function of Distance, Phase and Quality of an AuxiliarylacOperator
journal, March 1996

  • Müller, Johannes; Oehler, Stefan; Müller-Hill, Benno
  • Journal of Molecular Biology, Vol. 257, Issue 1
  • DOI: 10.1006/jmbi.1996.0143

Lac repressor and Lac operator
journal, January 1976


Construction of an ASD+ Expression-Cloning Vector: Stable Maintenance and High Level Expression of Cloned Genes in a Salmonella Vaccine Strain
journal, June 1988

  • Nakayama, Koji; Kelly, Sandra M.; Curtiss, Roy
  • Nature Biotechnology, Vol. 6, Issue 6
  • DOI: 10.1038/nbt0688-693

Antigen Sampling Across Epithelial Barriers and Induction of Mucosal Immune Responses
journal, April 1996


High efficiency transformation of Salmonella typhimurium and Salmonella typhi by electroporation
journal, August 1990

  • O'Callaghan, David; Charbit, Alain
  • MGG Molecular & General Genetics, Vol. 223, Issue 1
  • DOI: 10.1007/BF00315809

Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people
journal, February 1998


Temperature Regulation of the Hemin Storage (Hms+) Phenotype of Yersinia pestis Is Posttranscriptional
journal, March 2004


Essential Role for Cyclic AMP and Its Receptor Protein in Yersinia enterocolitica Virulence
journal, July 2002


Bacterial virulence, proinflammatory cytokines and host immunity: how to choose the appropriate Salmonella vaccine strain?
journal, November 2001


Altered cotransduction frequencies exhibited by HT-mutants of Salmonella-phage P22
journal, January 1976

  • Schmieger, Horst; Backhaus, Horst
  • MGG Molecular & General Genetics, Vol. 143, Issue 3
  • DOI: 10.1007/BF00269408

Phage P22-mutants with increased or decreased transduction abilities
journal, January 1972

  • Schmieger, Horst
  • MGG Molecular & General Genetics, Vol. 119, Issue 1
  • DOI: 10.1007/BF00270447

Universal chemical assay for the detection and determination of siderophores
journal, January 1987


A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells
journal, February 1983


Development of Oral Vaccines to Stimulate Mucosal and Systemic Immunity: Barriers and Novel Strategies
journal, February 1995


Anti-Polysaccharide Immunoglobulin Isotype Levels and Opsonic Activity of Antisera: Relationships with Protection against Streptococcus pneumoniae Infection in Mice
journal, August 1995

  • AlonsoDeVelasco, E.; Dekker, B. A. T.; Verheul, A. F. M.
  • Journal of Infectious Diseases, Vol. 172, Issue 2
  • DOI: 10.1093/infdis/172.2.562

Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli
journal, September 1988


The HD domain defines a new superfamily of metal-dependent phosphohydrolases
journal, December 1998


Breaking through the acid barrier: An orchestrated response to proton stress by enteric bacteria
journal, January 2001

  • Audia, Jonathon P.; Webb, Cathy C.; Foster, John W.
  • International Journal of Medical Microbiology, Vol. 291, Issue 2
  • DOI: 10.1078/1438-4221-00106

Acyl carrier protein/SpoT interaction, the switch linking SpoT-dependent stress response to fatty acid metabolism
journal, November 2006


The Complete Genome Sequence of Escherichia coli K-12
journal, September 1997


The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae
journal, December 2000


Salmonella redirects phagosomal maturation
journal, February 2004


Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens.
journal, July 1992

  • Cárdenas, L.; Clements, J. D.
  • Clinical Microbiology Reviews, Vol. 5, Issue 3
  • DOI: 10.1128/CMR.5.3.328

Simultaneous Analyses of Neutral Carbohydrates and Amino Sugars in Freshwaters with HPLC-PAD
journal, September 2003


The ACT domain family
journal, December 2001


Proteomic Characterization of Yersinia pestis Virulence
journal, November 2005


SseL Is a Salmonella-Specific Translocated Effector Integrated into the SsrB-Controlled Salmonella Pathogenicity Island 2 Type III Secretion System
journal, December 2006

  • Coombes, B. K.; Lowden, M. J.; Bishop, J. L.
  • Infection and Immunity, Vol. 75, Issue 2
  • DOI: 10.1128/IAI.00985-06

Nonrecombinant and recombinant avirulent Salmonella vaccines for poultry
journal, November 1996


Live oral avirulent Salmonella vaccines
journal, November 1993


One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
journal, May 2000

  • Datsenko, K. A.; Wanner, B. L.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 12, p. 6640-6645
  • DOI: 10.1073/pnas.120163297

Towards safer vectors for the field release of recombinant bacteria
journal, October 2002


Homocysteine Antagonism of Nitric Oxide-Related Cytostasis in Salmonella typhimurium
journal, April 1996


Induction of immunoglobulin synthesis by CD4+ T cell clones
journal, December 1993

  • DeKruyff, Rosemarie H.; Rizzo, Luiz V.; Umetsu, Dale T.
  • Seminars in Immunology, Vol. 5, Issue 6
  • DOI: 10.1006/smim.1993.1048

Bacteriology of acute otitis media: A new perspective
journal, January 1992

  • Del Beccaro, Mark A.; Mendelman, Paul M.; Inglis, Andrew F.
  • The Journal of Pediatrics, Vol. 120, Issue 1, p. 81-84
  • DOI: 10.1016/S0022-3476(05)80605-5

Genome Sequence of Yersinia pestis KIM
journal, August 2002


DNA Uptake in Bacteria
journal, October 1999


Improved allelic exchange vectors and their use to analyze 987P fimbria gene expression
journal, January 1998


How Salmonella Survive Against the Odds
journal, October 1995


Can a ‘flawless’ live vector vaccine strain be engineered?
journal, August 2001


The Use of Live Attenuated Bacteria as a Delivery System for Heterologous Antigens
journal, January 2003


recB recJ mutants ofSalmonella typhimurium are deficient in transductional recombination, DNA repair and plasmid maintenance
journal, March 1996

  • Garzón, Andrés; Beuzón, Carmen R.; Mahan, Michael J.
  • MGG Molecular & General Genetics, Vol. 250, Issue 5
  • DOI: 10.1007/BF02174445

Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation
journal, March 1996


The E. coli α-hemolysin secretion system and its use in vaccine development
journal, January 2002


Gastric Acidity and Cholera
journal, May 1973


Characterization of the Yersinia pestis Yfu ABC Inorganic Iron Transport System
journal, May 2001


TH1-TH2: a Procrustean paradigm
journal, June 2003

  • Gor, Dennis O.; Rose, Noel R.; Greenspan, Neil S.
  • Nature Immunology, Vol. 4, Issue 6
  • DOI: 10.1038/ni0603-503

Functional gene transfer from intracellular bacteria to mammalian cells
journal, September 1998

  • Grillot-Courvalin, Catherine; Goussard, Sylvie; Huetz, Frarnçois
  • Nature Biotechnology, Vol. 16, Issue 9
  • DOI: 10.1038/nbt0998-862

Magnitude and Impact of Diarrheal Diseases
journal, July 2002

  • Guerrant, Richard L.; Kosek, Margaret; Moore, Sean
  • Archives of Medical Research, Vol. 33, Issue 4, p. 351-355
  • DOI: 10.1016/S0188-4409(02)00379-X

Mechanisms of bacterial resistance and response to bile
journal, July 2000